Short-and long-term functional vs morphometrical salivary effects of irradiation in a rodent model

Anticancer Research

Volumn 18, Issue 1 A, 1998, Pages 315-320

  Nagler, Rafael M ^a,b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Function; Irradiation; Morphology; Morphometry; Saliva; Salivary glands

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FIBROSIS; HISTOPATHOLOGY; IRRADIATION; MALE; MORPHOMETRICS; NONHUMAN; ORGAN WEIGHT; PARENCHYMA; PAROTID GLAND; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RAT; SALIVARY GLAND FUNCTION; SUBMANDIBULAR GLAND; XEROSTOMIA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; ORGAN SIZE; PAROTID GLAND; RATS; RATS, WISTAR; SALIVATION; SUBMANDIBULAR GLAND;

EID: 0031899403     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Silverberg E, Lubera J: Cancer statistics. Cancer 37: 2-19, 1987.
2. Stephens LC, Schultheiss TE, Ang KK, Peters W: Pathogenesis of radiation injury salivary glands and potential methods of protection. Cancer Bull 41: 106-114, 1989.
3. Kashima HK, Kirkham WR, Andrews JR: Postirradiation silademitis. Am J Roentgenol 94: 271-291, 1965.
4. Dreizen S, Brown LR, Handler S, Levy BM: Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes. Cancer 38: 273-278, 1976.
5. Wescott WB, Mira JG, Starcke EN, Shannon IL, Thomby JI: Alterations in whole saliva flow rate induced by fractionated radiotherapy. Am J Roentgenol 130: 145-149, 1978.
6. Mossman K, Shakman A. Chencharick J: Long-term effects of radiotherapy on taste and salivary function in man. Int J Rad Oncol Biol Phys 8: 991-997, 1982.
7. Karlsson G: The relative change in saliva secretion in relation to the exposed area of the salivary glands after radiotherapy of head and neck region. Swed Dent J 11: 189-194, 1987.
8. Marks JE, Davis CC, Gottsman VL, Purdy JE, Lee F: The effects of radiation on parotid salivary function. Int J Rad Oncol Biol Phys 7: 1013-1019, 1981.
9. Eneroth CM, Henrikson CO, Jakobsson PA: Effect of fractionated radiotherapy on salivary function. Cancer 30: 1147-1153, 1972.
10. Valdez IH: Radiation induced salivary dysfunction: clinical course and significance. Special Care Dent 11: 252-255, 1991.
11. Bergonie J, et al: Sur quelques formes de reactions precoces apres des irradiations. Arch Elect Med 19: 241-245, 1991.
12. Nagler RM, Baum BJ, Fox PC: Acute effects of x-irradiation on the function of rat salivary glands. Radiat Res 136: 42-47, 1993.
13. Nagler RM, Baum BJ, Fox PC: A 2 week pair-fed study of early x-irradiation on rat major salivery gland function. Arch Oral Biol 41[7]: 713, 1996.
14. Nagler RM, Marmary Y, Fox PC, Baum BJ, Har-EI R, Chevion M: Irradiation induced damage to the salivary glands: the role of redoxactive iron and copper. Radiat Res [in press].
15. Nagler R, Nagler A: Effects of ionizing irradiation and B-adrenergic stimulation on gene expression in rat submandibular glands. Anticancer Res 16: 2749-2756, 1996.
16. Hiramatsu Y, Nagler RM, Fox PC, Baum BJ: Rat salivary gland blood flow and blood-to-tissue partition coefficients following x-irradiation. Arch Oral Biol 39: 7780, 1994.
17. Vissink A, 's-Gravenmade EJ, Ligeon EE, Konings AWT: A functional and chemical study of radiation effects on rat parotid and submandidular/ sublingual glands. Radiat Res 124: 259-265, 1990.
18. Vissink A, 's-Gravenmade EJ, Ligeon EE, Konings AWT: Effects of split-dose xirradiation on rat salivary gland function. Radiat Res 126: 001-006, 1991.
19. Mertz PM, Fox PC, Pluta A, Baum BJ, Kousvelari EE: Effects of ionizing radiation and β-adrenergic stimulation on the expression of early response genes in rat parotid glands. Radiat Res 130: 104-112, 1992.
20. Phillips RM: X-ray-induced changes in function and structure of the rat parotid gland. J Oral Surg 28: 432-437, 1970.
21. 137Cs irradiation. Radiat Res 90: 330-338, 1982.
22. Bodner L, Kuyatt BL, Hand AR, Baum BJ: Rat parotid cell function in vitro following x-irradiation in vivo. Radiat Res 97: 386-395, 1984.
23. Van den Brenk HAS, Stone MG: Effects of x-irradiation on salivary growth in the rat. III. Relative effects of local irradiation on wet weight, protein and nucleic acids of the salivary gland during postnatal growth and secretion and resynthesis of parotid amylase. Int J Radiat Biol 21: 247-256, 1972.
24. Conger AD, Sodicoff M, Samel A: Comparison of cAMP with other radioprotectors against chronic damage to the rat parotid gland. Radiat Res 10: 99-105, 1985.
25. Sodicoff M, Conger AD, Pratt NE, Trepper P: Radioprotection by WR-2721 against long-term chronic damage to the rat parotid gland. Radiat Res 76: 172-179, 1978.
26. Cherry CP, Glucksman A: Injury and repair following irradiation of salivary glands in male rats. Br J Radiol 32: 596-608, 1959.
27. Stem MH, Turner JE, Lett LS, Mincer H, McGinnis JP: Electron microscopic changes in rat parotid and submandibular glands subsequent to total body radiation with fast neutrons. Oral Surg Oral Med Oral Pathol 42: 620-630, 1976.
28. Sholley MM, Sodicoff M, Pratt NE: Early radiation injury in the rat parotid gland. Lab Invest 31: 340-354, 1974.
29. Omnell KAS, Qwarmstrom EE: A technique for intraoral cannulation and infusion of the rat submandibular gland. Dentomaxillofac Radiol 12: 13-15, 1983.
30. Aheme WA, Dunnill MS: Morphometry. London, Amold, 1982, pp 76-77, 82-83.
31. Scott J, Bodner L, Baum BJ: Assessment of age-related changes in the submandibular and sublingual salivary glands of the rat using stereological analysis. Arch Oral Biol 31: 69-71, 1986.
32. Nagler RM, Baum BJ, Fox PC: Effects of x-irradiation on the function of rat salivary glands at 3 and 40 days. Radiat Res 136: 392-396, 1993.
33. Rubin P, Casarett GW: Clinical radiation pathology as applied to curative radiotherapy. Cancer 22: 767-778, 1968.
34. Rubin P, Casarett GW: Clinical Radiation Pathology. Philadelphia, W.B.Saunders, 1968.
35. Vissink A, Konings AWT, Ligeon EE, 's-Gravenmade EJ: Irradiation-induced changes in secretion and composition of rat saliva. J Biol Buccale 18: 3-8, 1990.
36. Savage NW, Kruger BJ: Rat submandibular gland microvasculature following fractionated megavoltage irradiation. Aust Dent J 30: 99-103, 1985.
37. Savage NW, Kruger BJ, Atkins KF: The effects of fractionated megavoltage xirradiation on the rat submandibular gland: an assessment by light microscopy and autoradiography. Aust Dent J 30: 1-7, 1985.
38. Savage NW, Kruger BJ, Atkins KF: The effects of fractionated megavoltage xirradiation on the rat submandibular gbnd: an assessment by electron microscopy. Aust Dent J 30: 188-193, 1985.
39. Sasaki T: Latent and persistent lethal injury in mouse salivary gland cells following gamma irradiation. Radiat Res 67: 104-113, 1976.
40. Van den Brenk HAS, Hurley RA, Gomez C, Richter W: Serum amylase as a measure of salivary gland radiation damage. Br J Radiol 42: 688-700, 1969.
41. Menard TW, Izutsu KT, Ensign WY, Keller PJ, Morton TH, Truelove EL: Radioprotection by WR-2721 of gamma - irradiated rat parotid gland: Effect on gland weight and secretion at 8-10 days post radiation. Int J Radial Oncol Biol Phys 10: 1555-1559, 1984.