Inhibition of phenolsulphotransferase by salicylic acid: A possible mechanism by which aspirin may reduce carcinogenesis

Gut

Volumn 42, Issue 2, 1998, Pages 272-275

  Harris, R M ^a   Hawker, R J ^b   Langman, M J S ^a   Singh, S ^a   Waring, R H ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Colorectal cancer; Non steroidal anti inflammatory drugs; Phenolsulphotransferases

Indexed keywords

ACETYLSALICYLIC ACID;

ADULT; ARTICLE; CANCER RISK; CLINICAL ARTICLE; COLON MUCOSA; DIGESTIVE SYSTEM CANCER; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0031899371     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.2.272     Document Type: Article

References (27)

1. Levy G. Pharmacokinetics of salicylate in man. Drug Metab Rev 1979;9:3 19.
2. Needs CJ, Brooks PM. Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet 1985;10:164-77.
3. Morgan AM, Truitt EB. Evaluation of acetylsalicylic acid esterase in aspirin metabolism. J Pharm Sci 1965;54:1640 6.
4. Rowland M, Riegelman S, Harris PA, Sholkoff SD, Absorption kinetics of aspirin in man following oral administration of an aqueous solution. J Pharm Sci 1972;61:379 85.
5. Hogben CAM, Tocco DJ, Brodie BB, Schanker LS. On the mechanism of intestinal absorption of drugs. J Pharmacol Exp Ther 1959;125:275-81.
6. Schanker LS, Tocco DJ, Brodie BB, Hogben CAM. Absorption of drugs from the rat small intestine. J Pharmacol Exp Ther 1958;123:81-8.
7. Elder DJE, Hague A, Hicks DJ, Paraskeva C. Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma cell lines. Cancer Res 1996;56:2273 6.
8. Rosenberg L, Palmer JR, Zauber AG, Warshauer ME, Stolley PD, Shapiro S. A hypothesis: nonsteroidal antiinflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst 1991;83:355-8.
9. Thun MJ, Namboodiri MM, Heath CW. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 1991;325: 1593-6.
10. Greenberg ER, Baron JA, Freeman DH, Mandel JS, Haile R. Reduced risk of large-bowel adenomas among aspirin users. J Natl Cancer Inst 1991;85:912-6.
11. Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 1992;52:5575-89.
12. Rao SI, Duffel MW. Inhibition of aryl sulfotransferase by carboxylic acids. Drug Metab Dispos 1991;19:543-5.
13. Boberg EW, Miller EC, Miller JA, Poland A, Liem A. Strong evidence from studies with brachymorphic mice and pentachlorophenol: that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver. Cancer Res 1983;43:5163-73.
14. Tsutsumi M, Noguchi O, Okita S, et al. Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters. Carcinogenesis 1995;16:457-9.
15. Weinshilboum R. Sulfotransferase pharmacogenetics. In: Kalow W, ed. Pharmacogenetics of drug metabolism. New York: Pergamon Press, 1992:227-42.
16. Coughtrie MWH. Sulphation catalysed by the human cytosolic sulphotransferases - chemical defence or molecular terrorism? Hum Expl Toxicol 1996;15:547-55.
17. Foldes A, Meek JL. Rat brain phenolsulfotransferasepartial purification and some properties. Biochim Biophys Acta 1973;327:365-74.
18. Anderson RJ, Weinshilboum RM. Phenolsulphotransferase in human tissue: radiochemical enzymatic assay and biochemical properties. Clinica Chimica Acta 1980;103:79-80.
19. Harris RM, Waring RH. Dietary modulation of human platelet phenolsulphotransferase activity. Xenobiotica 1996; 26:1241-7.
20. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72: 248-54.
21. Grover PL. Pathways involved in the metabolism and activation of polycyclic hydrocarbons. Xenobiotica 1986;16: 915-31.
22. Hernández JS, Powers SP, Weinshilboum RM. Human liver arylamine n-sulfotransferase activity. Thermostable phenol sulfotransferase catalyzes the N-sulfation of 2-naphthylamine. Drug Metab Dispos 1991;19:1071 -9.
23. Chou H-C, Lang NP, Kadlubar FF. Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s). Cancer Res 1995;55:525-9.
24. Weinshilboum RM, Otterness DM, Aksoy IA, Wood TC, Her C, Raftogianis RB. Sulfotransferase molecular biology: cDNAs and genes. FASEB J 1997;11:3-14.
25. Ghazali RA, Waring RH, Helsby N. Metabolism of dietary flavonoids. ISSX Proceedings 1996;9:42.
26. Rainsford KD. The effects of aspirin and other non-steroid anti-inflammatory analgesic drugs on gastro-intestinal mucus glycoprotein biosynthesis in vivo: relationship to ulcerogenic actions, Biochem Pharmacol 1978;27:877-85.
27. Giovannucci E, Egan KM, Hunter DJ, et al. Aspirin and the risk of colorectal cancer in women. N Engl J Med 1995;333:609-14.