Influence of aging on cortical and trabecular bone response to estradiol treatment in ovariectomized rats

Gerontology

Volumn 44, Issue 3, 1998, Pages 132-139

  Gaumet, N ^a   Braillon, P ^b   Seibel, M J ^c   Pointillart, A ^a   Coxam, V ^a   Davicco, M J ^a  

^a CEMAGREF   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Aging; Cortical bone; Estrogen; Ovariectomy; Rat; Trabecular bone

Indexed keywords

BIOCHEMICAL MARKER; CALCIUM; DEOXYPYRIDINOLINE; ESTRADIOL; OSTEOCALCIN; PHOSPHATE; SOLVENT;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE ATROPHY; BONE DENSITY; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; DIETARY INTAKE; ESTROGEN THERAPY; FEMALE; FEMUR; IMAGE ANALYSIS; NONHUMAN; OSTEOPENIA; OVARIECTOMY; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TIBIA; TRABECULAR BONE; URINE LEVEL;

EID: 0031899290     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000021996     Document Type: Article

References (43)

1. Melton LJ III, Atkinson EJ, O'Fallon MW, Wahner HW, Riggs BL: Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 1993;8:1227-1233.
2. Black DM, Cummings SR, Genant HK, Nevitt MC, Palermo L, Browner WS: Axial bone density predicts fractures in older women. J Bone Miner Res 1992;7:633-638.
3. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC: Long-term prevention of postmenopausal osteoporosis by estrogen. Lancet 1976;i:1038-1041.
4. Christiansen C, Christiansen MS, McNair P: Prevention of early post-menopausal bone loss: Conducted 2-year study in 315 normal females. Eur J Clin Invest 1980;10:273-279.
5. Horsman A, Gallagher JC, Simpson M, Nordin BEC: Prospective trial of estrogen and calcium in postmenopausal women. Br Med J 1977;ii:789-792.
6. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ: Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992;327:1637-1642.
7. Jones G, Nguyen T, Kelly PJ, Eisman JA: Progressive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 1994;309:691-695.
8. Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD: Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 1996;11:337-349.
9. Lindsay R, Tohme JF: Estrogen treatment of patients with established postmenopausal osteoporosis. Obstet Gynecol 1990;76:290-295.
10. Marx CW, Dailey GE III, Cheney C, Vint VC II, Muchmore DB: Do estrogens improve bone mineral density in osteoporotic women over age 65? J Bone Miner Res 1992;7:1275-1279.
11. Lips P, Courpron P, Meunier PJ: Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age. Calcif Tissue Res 1978;26:13-17.
12. Reid SA, Boyde A: Changes in the mineral density distribution in human bone with age: Image analysis using backscattered electrons in the SEM. J Bone Miner Res 1987;2:13-22.
13. Wronski TJ, Dann LM, Scott KS, Cintron M: Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 1989;45:360-366.
14. Hagaman JR, Ambrose WW, Hirsch PF, Kiebzak GM: Age-related changes in rat trabecular, endosteal, and cortical bone demonstrated with scanning electron microscopy. Cells Mater 1991(suppl 1):37-46.
15. Juhn A, Weiss A, Mendes D, Silbermann M: Non invasive assessment of bone mineral density during maturation and aging of Wistar female rats. Cells Mater 1991(suppl 1):19-24.
16. Kalu DN, Liu CC, Hardin RR, Hollis BW: The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 1989;124:7-16.
17. Heaney RP: Is there a role for bone quality in fragility fractures? Calcif Tissue Int 1993;53(suppl 1):S3-S5.
18. Recker RR: Low bone mass not be the only cause of skeletal fragility in osteoporosis. Proc Soc Exp Biol Med 1989;191:272-274.
19. Foldes J, Parfitt AM, Shih MS, Rao DS, Kleerekoper M: Structural and geometric changes in iliac bone: Relationship to normal aging and osteoporosis. J Bone Miner Res 1991;6:759-766.
20. Mosekilde LI, Kragstrup J, Richards A: Compressive strength, ash weight, and volume of vertebral trabecular bone in experimental fluorosis in pigs. Calcif Tissue Int 1987;40:318-322.
21. Riggs L, Hodgson SF, O'Fallon WM, Chao EYS, Wahner HW, Muhs JM, Cedel SL, Melton LJ: Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoprosis. N Engl J Med 1990;322:802-809.
22. Tartellin MF, Gorski RA: The effects of ovarian steroids on food and water intake and body weight in the female rat. Acta Endocrinol 1973;72:551-568.
23. Seibel MJ, Duncan A, Robins SP: Urinary hydroxy-pyridinium crosslinks of collagen reflect cartilage and bone involvement in rheumatic joint diseases. J Rheumatol 1989;16:964-970.
24. Pointillart A, Colin C, Lacroix HC, Guégen L: Mineral bioavailability and bone mineral contents in pigs given calcium carbonate postprandially. Bone 1995;17:357-362.
25. Gaumet N, Seibel MJ, Braillon P, Giry J, Lebecque P, Davicco MJ, Coxam V, Rouffet J, Delmas PD, Barlet JP: Influence of ovariectomy on bone metabolism in very old rats, Calcif Tissue Int 1996;58:256-262.
26. Rose N, Constantin P, Leterrier C: Sex difference in bone growth of broiler chickens. Growth Dev Aging 1996;60:49-59.
27. Robins SP: Crosslinks of collagen: Isolation, structural characterization and glycosylation of pyridinoline. Biochem J 1983;215:167-163.
28. Robins SP: Biochemical markers for assessing skeletal growth. Eur J Clin Nutr 1994;48(suppl 1):S199-S209.
29. Cook JGH: Factors influencing the assay of creatinine. Ann Clin Biochem 1975;12:219-232.
30. Danielsen CC, Mosekilde L, Svenstrup B: Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int 1993;52:26-33.
31. Griffin MG, Kimble R, Hopfer W, Pacifici R: Dual energy X-ray absorptiometry of the rat: Accuracy, precision and measurement of bone loss. J Bone Miner Res 1993;8:795-800.
32. Snen V, Dempster DW, Birchman R, Xu R, Lindsay R: Loss of cancellous bone mass and Connectivity in ovariectomized rats can be restored by combinant treatment with parathyroid hormone and estradiol. J Clin Invest 1993;91:2479-2487.
33. Barengolys El, Curry DJ, Botsis J, Kukreja SC: Comparison of the effects of progesterone and estrogen on established bone loss in ovariectomized aged rats. Cells Mater 1991(suppl 1):105-111.
34. Bagi CM, Miller SC: Comparison of osteopenic changes in cancellous bone induced by ovariectomy and/or immobilization in adult rat. Anat Rec 1994;239:239-243.
35. Miller SG, Wronski TJ: Long-term osteopenic changes in cancellous bone structure in ovariectomized rats. Anat Rec 1993;236:433-441.
36. Kiebzak GM, Smith R, Gundberg CC, Howe JC, Sacktor B: Bone status of senescent male rats: Chemical, morphometric, and mechanical analysis. J Bone Miner Res 1987;3:37-45.
37. Kiebzak GM, Smith R, Howe JC, Sacktor B: Bone mineral content in the senescent rat femur: An assessment using single photon absorptiometry. J Bone Miner Res 1988;3:311-317.
38. Shen V, Birchman R, Xu R, Lindsay R, Dempster DW: Short-term changes in histomorphometric and biochemical turnover markers and bone mineral density in estrogen-and/or dietary calcium-deficient rats. Bone 1995;16:149-156.
39. Kalu DN: Evaluation of pathogenesis of skeletal changes in ovarieetomized rats. Endocrinology 1984;115:507-512.
40. Ibboston KJ, Orcutt CM, D'Souza SM, Paddock CL, Arthur JA, Jankowsky ML, Boyce RW: Contrasting effects of parathyroid hormone and insulin-like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis. J Bone Miner Res 1992;7:425-432.
41. Baumann DB, Wronski TJ: Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomized rats. Bone 1995;16:247-253.
42. Pohlman RL, Darby LA, Lechner AJ: Morphometry and calcium contents in appendicular and axial bones of exercised ovariectomized rats. Am J Physiol 1985;248:R12-R17.
43. Delmas PD: Clinical use of biochemical markers of bone remodeling in osteoporosis. Bone 1992;13:517-521.