Protection of xeno-hepatocytes from complement-mediated cytolysis by transduction with homologous restriction factor 20 gene using retroviral vector

European Surgical Research

Volumn 30, Issue 3, 1998, Pages 161-167

  Hayashi, S ^a   Isobe, K ^a   Emi, N ^a   Okada, H ^b   Yokoyama, I ^a   Takagi, H ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Gene engineering; Hepatocyte; HRF20; Xenotransplantation

Indexed keywords

CD59 ANTIGEN; COMPLEMENT; COMPLEMENTARY DNA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOLYSIS; EXPRESSION VECTOR; FLOW CYTOMETRY; GENETIC ENGINEERING; GENETIC TRANSDUCTION; LIVER CELL; LIVER DISEASE; LIVER TRANSPLANTATION; MALE; METABOLIC DISORDER; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RETROVIRUS; XENOTRANSPLANTATION;

ANIMALS; ANTIGENS, CD59; CELL TRANSPLANTATION; COMPLEMENT SYSTEM PROTEINS; CYTOTOXICITY, IMMUNOLOGIC; DNA, COMPLEMENTARY; GENETIC VECTORS; HUMANS; LIVER; MALE; RATS; RATS, WISTAR; RETROVIRIDAE; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0031898509     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000008572     Document Type: Article

References (32)

1. Starzl TE, Fung J, Tzakis A, Todo S, Demetris AJ, Marino IR, Doyle H, Zeevi A, Warty V, Michaels M, Kusne S, Rudert WA, Trucco M: Baboon-to-human liver transplantation. Lancet 1991;341:65-71.
2. Rozga J, Podesta L, LePage E, Morsiani E, Moscioni AD, Hoffman A, Sher L, Villamil F, Woolf G, McGrath M, Kong L, Rosen H, Lanman T, Vierling J, Makowka L, Demetriou AA: A bioartificial liver to treat severe acute liver failure. Ann Surg 1994;219:538-546.
3. Chowdhury JR, Grossman M, Gupta S. Chowdhury NR, Baker JR, Wilson JM: Long-term improvement of hypercholestrolemia after ex vivo gene therapy in LDLR-deficiem rabbits. Science 1991;254: 1802-1805.
4. Demetriou AA, Whiting JF, Feldman D, Levenson SM, Chowdhury NR, Moscioni AD, Kram M, Chowdhury JR: Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 1986;233-1190-1992.
5. Dixit V, Darvasi R, Arthur M, Brezina M, Lewin KL, Gitnick G: Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes. Hepatology 1990;12: 1342-1349.
6. Makowka L, Falk RE, Rotstein LE, Falk JA, Nossal N, Langer B, Blendis LM, Phillips MJ: Cellular transplantation in the treatment of experimental hepatic failure. Science 1980;210:901-903.
7. Cooper DKC, Ye Y, Rolf LL, Zuhdi N: The pig as potential organ donor for man; in Cooper DKC, Kemp E, Reemtsma K, White DJG (eds): Xenotransplantation, Heidelberg. Springer, 1990, pp 481-502.
8. Sachs DH, Bach FH: Immunology of xenograft rejection. Hum Immunol 1990;28:245-251.
9. Bach FH: Revisiting a challenge in transplantation: Discordant xenografting. Hum Immunol 1991;30: 262-269.
10. Dalmasso AP, Vercelloui GM, Fischel RJ, Bolman RM, Bach FH, Platt JL: Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients: Am J Pathol 1992;140:1157-1166.
11. Hayashi S, Ito M, Yokoyama I, Takagi H: Evidence that combination therapy using cobra venom factor, splenectomy, and deoxyspergualin is effective in guinea pig to rat cardiac xenotransplantation. Transplantation 1994;57:777-779.
12. Dalrnasso AP, Vercellotti GM, Platt JL, Bach FH: Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Transplantation 1991;52:530-533.
13. White DJG, Oglesby T, Liszewski MK, Tedjia I, Hourcade D, Wang MW, Wright L, Wallwork J, Atkinson JP: Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement. Transplant Proc 1992;24; 474-476.
14. Takizawa H, Takahashi K, Murakami T, Okada N, Okada H: Species specific restriction of complement by HRF20 (CD59) generated by cDNA transfection, Eur J Immunol 1992;22:1943-1947.
15. Zhao J, Rollins SA, Maher SE, Bothwell ALM, Sims PJ: Amplified gene expression in CD59-tranafected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement. J Biol Chem 1991;20:13418-13422.
16. Moscioni AD, Roy-Chowdhury J, Barbour R, Brown LL, Roy-Chowdhury N, Competiello LS, Lahiri P, Demetriou AA: Human liver cell transplantation: Prolonged function in athymic-Gunn and athymic-analbuminemic hybrid rats. Gastroenterology 1989;96:1546-1551.
17. Cuervas-Mons V, Canton T, Escandon J, Nieto J, Ramos J, Menendez J, Ortiz J, Castillo-Olivares JL, Segovia JM: Monitoring of the rejection of intrasplenic hepatocyte allografts and xenografts in the rat using technetium 99m-Lmidoacetic acid scanning. Transplant Proc 1987;19: 3850-3851.
18. Makowka L, Rotstein LE, Falk RE, Falk JA, Zuk R, Langer B, Blendis LM: Allogeneic and xenogeneic hepatocyte transplantation. Transplant Proc 1981;13:855-859.
19. Xu L, Yee JK, Wolff JA, Friedmann T: Factors affecting long-term stability of moloaey murine leukemia virus-based vectors. Virology 1989; 71:331-341.
20. Okada H, Nagami Y, Takahashi K, Okada N, Hideshima T, Takizawa H, Kondo J: 20kDa homologous restriction factor of complement resembles T cell activating protein. Biochem Biophys Res Commun 1989;162:1553-1559.
21. Maniatis T, Fritsch FF, Sambrook J: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory, 1982, vol 2, pp 14.5-14.34.
22. Harada R, Okada N, Fujita T, Okada H: Purfication of 1F5 antigen that prevents complement attack on homologous cell membranes. J Immunol 1990;144:1823-1828.
23. Abe A, Takeo T, Emi N, Morishima Y. Ueda R, Yee JK, Friedmann T, Saito H: Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector. Proc Soc Exp Biol Med 1993;203:354-357.
24. Kay MA, Rothenberg S, Landen CN, Bellinger DA, Leland F, Toman C, Finegold M, Thompson AR, Read MS, Brinkhous KM: In vivo gene therapy of hemophilia B: Sustained partial correction in factor IX-deficient dogs. Science 1993; 262:117-119.
25. Kay MA, Li Q, Liu TJ, Leland F, Toman C, Finegold M, Woo SLC: Hepatic gene therapy: Persistent expression of human al-antitrypsin in mice after direct gene delivery in vivo. Hum Gene ther 1992;3:641-647.
26. Hayashi S, Emi N, Isobe K, Yokoyama I, Okada H, Takagi H: Inhibitory effect of double transfection to xenoendothelial cells using both decay accelerating factor and homologous restriction factor 20 genes on complement dependent cytolysis. J Surg Res 1996;61:165-169.
27. Hayashi S, Isobe K, Emi N, Yokoyama I, Okada H, Nakashima I, Takagi H: Inhibition of human complement dependent cell lysis by bovine aortic endothelial cells transfected with membrane-bound complement regulatory factor (DAF and HRF20) gene using a retorviral vector. Eur Surg Res 1996;28:440-446.
28. Oriol R, Ye Y, Koren E, Cooper DKC: Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993;56: 1433-1438.
29. Neethling FA, Koren E, Ye Y, Richards SV, Kujundzic M, Oriol R, Cooper DKC: Protection of pig kidney (PK 15) cells from the cytotoxic effect of anti-pig antibodies by a-galactosyl oligosaccharides. Transplantation 1994;57:959-963.
30. Atkinson JP, Farries T: Separation of self from non-self in the complement system. Immunol Today 1987; 8:212-215.
31. Miyagawa S, Hirose H, Shirakura R, Naka Y, Nakata S, Kawashima Y, Seya T, Matsumoto M, Uenaka A, Kitamura H: The mechanism of discordant xenograft rejection. Transplantation 1988;46:825-830.
32. White D, Wallwork J: Xenografting: probability, possibility, or pipe dream? Lancet 1993;342:879.