Inhibition of glycine-induced current by morphine in nucleus tractus solitarii neurones of guinea pigs

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 20, Issue 2, 1998, Pages 125-132

  Fukushima, Hidenao ^a   Nagayama, Shin Ichi ^a   Otsuka, Mikio ^a   Takahama, Kazuo ^a   Isohama, Yoichiro ^a   Kai, Hirofumi ^a   Miyata, Takeshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Antitussive; Dissociated neurones; Glycine; Guinea pig; Morphine; Nucleus tractus solitarii; Whole cell recording

Indexed keywords

GLYCINE; GLYCINE RECEPTOR; MORPHINE;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; GUINEA PIG; NONHUMAN; PAIN; PATCH CLAMP; SOLITARY TRACT NUCLEUS; VOMITING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; GLYCINE; GUINEA PIGS; MORPHINE; NEURONS; PATCH-CLAMP TECHNIQUES; SEROTONIN ANTAGONISTS; SOLITARY NUCLEUS;

EID: 0031898444     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1998.20.2.485646     Document Type: Article

References (20)

1. Schult, D.W., MacDonald, R.L. Barbiturate enhancement of GABA mediated inhibition and activation of chloride ion conductance: Correlation with anticonvulsant and anesthetic actions. Brain Res 1981, 209: 177-88.
2. Olsen, R.W., Fischer, J.B., Dunwiddie, T.V. Barbiturate enhancement of γ-aminobutyric acid receptor binding and function as a mechanisms of anesthesia. In: Molecular Mechanism of Anesthesia. Roth, S., Miller, K. (Eds.). Plenum: New York 1982, 165-77.
3. Ticku, M.K., Rastogi, S.K. Barbiturate-sensitive sites in the henzodiazepine-GABA-receptor-ionophore complex. In: Molecular and Cellular Mechanism of Anesthesia. Roth, S.H., Miller, K.W. (Eds.), Plenum: New York 1986, 179-88.
4. Yakushiji, T., Tokutomi, N., Akaike, N. Augmentation of GABA induced chloride current in frog sensory neurons by diazepam. Neurosci Res 1989, 6: 309-20.
5. Takahama, K., Fukushima, H., Isohama, Y., Kai, H., Miyata, T. Inhibition of glycine currents by dextromethorphan in neurones dissociated from the guinea-pig nucleus tractus solitarii. Br J Pharmacol 1997, 120: 690-4.
6. Honda, H., Takahama, K., Kawaguchi, T., Fuchikami, J., Kai, H., Miyata, T. Involvement of N-methyl-D-aspartic acid (NMDA) receptor in the central mechanism of cough reflex. Jpn J Pharmacol 1990, 52 (Suppl. I): 308P.
7. Gruol, D.L., Smith, T.G. Opiate antagonism of glycine-evoked membrane polarization in cultured mouse spinal cord neurons. Brain Res 1981, 223: 355-65.
8. Werz, M.N., MacDonald, R.L. Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action. Brain Res 1982, 236: 107-19.
9. Fan, P. Nonopioid mechanism of morphine modulation of the activation of 5-hydroxytryptamine type 3 receptors. J Pharmacol Exp Ther 1995, 47: 491-5.
10. 3 antagonists in rat spinal neurones. Br J Pharmacol 1996, 118: 2115-25.
11. Xu, TL., Nabekura, J., Akaike, N. Protein kinase C-mediated enhancement of glycine response in rat sacral dorsal commissural neurones by serotonin. J Physiol 1996, 496: 491-501.
12. Huguenard, J.R., Alger, B.R. Whole-cell voltage clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons. J Neurophysiol 1986, 56: 1-18.
13. Hamill, O.P., Marty, A., Neher, E., Sackmann, B., Sigworth, F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981, 391: 85-100.
14. Murase, K., Ryu, P.D., Randic, M. Excitatory and inhibitory amino acids and peptide-induced response in acutely isolated rat spinal dorsal horn neurons. Neurosci Lett 1989, 103: 56-63.
15. Goldinger, A., Muller, W.E., Wollert, U. Inhibition of glycine and GABA receptor binding by several opiate agonists and antagonists. General Pharmacol 1981, 12: 477-82.
16. 1A receptors, on the cough reflex in rats. Eur J Pharmacol 1991, 203: 253-8.
17. Kristhal, O.A., Osipchuk, Yu, V., Vrublevsky, S.V. Properties of glycine activated conductances in rat brain neurones. Neurosci Lett 1988, 84: 271-6.
18. Akaike, N., Kaneda M. Glycine-gated chloride current in acutely isolated rat hypothalamic neurons. J Neurophysiol 1989, 62: 1400-9.
19. Houamed, K.M., Bilbe, G., Smart, T.G., Constanti, A., Brown, D.A., Barnard, E.A., Richards, B.M. Expression of functional GABA, glycine and glutamate receptors in xenopus oocytes injected with rat brain mRNA. Nature 1984, 310: 318-21.
20. Otsuka, M., Takahama, K., Fukushima, H., Kai, H., Isohama, Y., Takeshi, M. Is the inhibitory action of antitussives on glycine-induced currents necessary for production of antitussive activity? Folia Pharmacol Japon 1996, 107: 60P (in Japanese).