Monitoring in situ liver metabolism in rats using microdialysis. Comparison of microdialysis mass-transport model predictions to experimental metabolite generation data

Journal of Pharmaceutical Sciences

Volumn 87, Issue 3, 1998, Pages 311-320

  Stenken, Julie A ^a,b   Ståhle, Lars ^c   Lunte, Craig E ^a   Southard, Marylee Z ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Rensselaer Polytechnic Institute   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PARACETAMOL; PHENACETIN;

ARTICLE; COMPARATIVE STUDY; DIALYSATE; DRUG DETERMINATION; DRUG METABOLISM; LIVER METABOLISM; MATHEMATICAL MODEL;

EID: 0031896644     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js970288z     Document Type: Article

References (45)

1. Robinson, T. E.; Justice, J. B., Jr., Eds. Microdialysis in the Neurosciences; Elsevier: Amsterdam, 1991.
2. Ungerstedt, U. Microdialysis-Principles and applications for studies in animals and man. J. Internal. Med. 1991, 230, 365-373.
3. Lunte, S. M.; Lunte, C. E. Microdialysis sampling for pharmacological studies: HPLC and CE analysis. In Advances in Chromatography; Brown P. R., Grushka, E., Eds.; Marcel Dekker Inc.: New York, 1996; Vol. 36, pp 383-432.
4. Davies, M. I.; Lunte, C. E. Simultaneous microdialysis sampling from multiple sites in the liver for the study of phenol metabolism. Life Sci. 1996, 59, 1001-1013.
5. Van Belle, K.; Sarre, S.; Ebinger, G.; Michotte, Y. Brain, liver, and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats: A quantitative microdialysis study. J. Pharmacol. Exp. Ther. 1995, 272, 1217-1222.
6. Scott, D. O.; Lunte, C. E. In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol. Pharm. Res. 1993, 10, 335-342.
7. Ståhle, L.; Segersvärd, S.; Ungerstedt, U. Drug distribution studies with microdialysis. II. Caffeine and theophylline in blood, brain, and other tissues in rats. Life Sci. 1991, 49, 1843-1852.
8. Ungerstedt, U; Herrera-Marschitz M; Jungnelius, U; Ståhle, L; Tossman, U.; Zetterström, T. Dopamine synaptic mechanisms reflected in studies combining behavioral recordings and brain dialysis. In Advances in Dopamine Research; Kohsaka, M., Ed.; Pergamon Press: New York, 1982; pp 219-231.
9. Ault, J. M.; Riley, C. M.; Meltzer, N. M.; Lunte, C. E. Dermal microdialysis sampling in vivo. Pharm. Res. 1994, 11, 1631-1639.
10. Bungay P. M.; Morrison P. F.; Dedrick R. L. Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci. 1990, 46, 105-119.
11. Morrison, P. F.; Bungay, P. M.; Hsiao, J. K.; Mefford, I. V.; Dykstra, K. H.; Dedrick, R. L. Quantitative microdialysis. In Microdialysis in the Neurosciences, Robinson, T. E., Justice, J. B., Jr., Eds.; Elsevier: Amsterdam, 1991; pp 47-80.
12. Dykstra, K. H.; Arya, A.; Arriola, D. M.; Bungay, P. M.; Morrison, P. F.; Dedrick, R. L. Microdialysis study of zidovudine (AZT) transport in rat brain. J. Pharmacol. Exp. Ther. 1993, 267, 1227-1236.
13. Wallgren, F.; Amberg, G.; Hickner, R. C.; Ekelund, U.; Jorfeldt, L.; Henriksson, J. A mathematical model for measuring blood flow in skeletal muscle with the microdialysis ethanol technique. J. Appl. Physiol. 1995, 72, 648-659.
14. Hickner, R. C.; Ekelund, U.; Mellander, S.; Ungerstedt, U.; Henriksson, J. Muscle blood flow in the cat: comparison of the microdialysis ethanol technique to direct measurement. J Appl. Physiol. 1995, 79, 638-647.
15. Stenken, J. A.; Lunte, C. E.; Southard, M. Z.; Ståhle, L. Factors that influence microdialysis recovery. Comparison of experimental and theoretical microdialysis recoveries in rat liver. J. Pharm. Sci. 1997, 86, 958-966.
16. Rappaport, A. M. The structural and functional unit in the human liver (liver acinus). Anat. Rec. 1958, 130, 673-689.
17. Arias, I. M.; Jakoby, W. B.; Popper, H.; Schachter, D., Eds. The Liver: Biology and Pathobiology, 2nd ed.; Raven Press Ltd.: New York, 1988.
18. Pang, K. S.; St-Pierre, M. V. Hepatic modeling of drugs and metabolites. In Biliary Excretion of Drugs and Other Chemicals; Progress in Pharmacology and Clinical Pharmacology; Siegers, C-P, Watkins, J. B., Eds.; Gustav Fischer Verlag: Stuttgart, 1991; Vol. 8, pp 89-126.
19. Pang, K. S. Kinetics of conjugation reactions in eliminating organs. In Conjugation Reactions in Drug Metabolism; Mulder, G. J., Ed.; Taylor and Francis: London, 1990; pp 5-39.
20. Gillette, J. R. Kinetic aspects of metabolism and elimination of foreign compounds in animals. In Enzymatic Basis of Detoxication; Jakoby, W. B., Ed.; Academic Press, Inc.: Orlando, 1980; Vol. 1, pp 9-24.
21. Gores, G. J.; Kost, L. J.; LaRusso, N. F. The isolated perfused rat liver: Conceptual and practical considerations. Hepatology 1986, 6, 511-517.
22. Bass L; Keiding S. Physiologically based models and strategic experiments in hepatic pharmacology. Biochem. Pharmacol. 1988, 37, 1425-1431.
23. Smith, R. L.; Timbrell, J. A. Factors affecting the metabolism of phenacetin I. Influence of dose, chronic dosage, route of administration and species on the metabolism of (1-c14-acetyl)phenacetin. Xenobiotica 1974, 4, 489-501.
24. Miner, D. J.; Kissinger, P. T. Evidence for the involvement of N-acetyl-p-quinoneimine in acetaminophen metabolism. Biochem. Pharmacol. 1979, 3285-3290.
25. Van Belle K.; Sarre S.; Ebinger G.; Michotte Y. Quantitative microdialysis for the in vivo measurement of carbamazepine, oxcarbazepine and their major metabolites in rat brain and liver tissue and in blood using the internal standard technique. Eur. J. Pharm. Sci. 1995, 3, 273-280.
26. Stenken, J. A. Identification and Modeling of Parameters that Influence Microdialysis Sampling in vitro and in vivo. Ph.D. Dissertation, University of Kansas, 1995.
27. Carnahan, B.; Luther, H. A.; Wilkes, J. O. Applied Numerical Methods. Robert E. Krieger Publishing: Malabar, FL, 1990.
28. Press, W. H.; Flanner, B. P.; Teukolsky, S. A.; Vetterling, W. T. Numerical Recipes in FORTRAN: The Art of Scientific Computing, 2nd ed.; Cambridge University Press: Cambridge, 1986.
29. Laidler, K. J. Chemical Kinetics, 3rd ed.; Harper Collins Publishers: New York, 1987; p 401.
30. Rice, M. E.; Gerhardt, G. A.; Hierl, P. M.; Nagy, G.; Adams, R. N. Diffusion coefficients of neurotransmitters and their metabolites in brain extracellular fluid space. Neuroscience 1985, 15, 891-902.
31. Rice, M. E.; Nicholson, C. Diffusion and ion shifts in the brain extracellular microenvironment and their relevance for voltammetric measurements. The brain is not a beaker: In vivo vs In vitro voltammetry. In Neuromethods, Vol. 27: Voltammetric Methods in Brain Systems; Boulton, A., Baker, G.; Adams, R. N., Eds.; Humana Press Inc. New York, 1995; pp 27-79.
32. Houston, J. B. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem. Pharmacol. 1994, 47, 1469-1479.
33. Hayes, K. A.; Brennan, B.; Chenery, R.; Houston, J. B. In vivo disposition of caffeine predicted from hepatic microsomal and hepatocyte data. Drug Metab. Disp. 1995, 23, 349-353.
34. Ichikawa, M.; Tsao, S. C.; Lin, Tsu-H.; Miyauchi, S.; Sawada, Y.; Iga, T.; Hanano, M.; Sugiyama, Y. 'Albumin-mediated transport phenomenon' observed for ligands with high membrane permeability: Effect of the unstrirred water layer in the Disse's space of rat liver. J. Hepatol. 1992, 16, 38-49.
35. Davies, M. I.; Lunte, C. E. Microdialysis sampling for hepatic metabolism studies: Impact of microdialysis probe design and implantation technique on liver tissue. Drug Metab. Disp. 1995, 23, 1072-1079.
36. Morris, M. E.; Pang, K. S. Competition between two enzymes for substrate removal in liver: Modulating effects due to substrate recruitment of hepatocyte activity. J. Pharmacokin. Biopharm. 1987, 15, 473-496.
37. Scott, D. O.; Lunte, C. E. In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol. Pharm. Res. 1993, 10, 335-342.
38. Iida, S.; Mizuma, T.; Sakuma, N.; Hayashi, M.; Awazu, S. Transport of acetaminophen conjugates in isolated rat hepatocytes. Drug Metab. Disp. 1989, 17, 341-344.
39. Barrow, G. N. Physical Chemistry, 5th ed.; McGraw Hill Book Co.: New York, 1988; p 803.
40. 18
41. Goresky, C. A.; Pang, K. S.; Schwab, A. J.; Barker, F. I., Cherry, W. F.; Bach, G. G. Uptake of a protein-bound polar compound, acetaminophen sulfate by perfused rat liver. Hepatology 1992, 16, 173-190.
42. Koster, H.; Halsema, I.; Scholtens, E.; Knippers, M.; Mulder, G. J. Dose-dependent shifts in the sulfation and glucuronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes: The role of saturation of phenolsulfotransferase. Biochem. Pharmacol. 1981, 30, 2569-2575.
43. Pang K. S.; Terrell J. A. Conjugation kinetics of acetaminophen by the perfused rat liver preparation. Biochem. Pharmacol. 1981, 30, 1959-1965.
44. Sam, P. M.; Justice, J. B., Jr. Effect of general microdialysis-induced depletion on extracellular dopamine. Anal. Chem. 1996, 68, 724-728.
45. Stahle, L. Microdialysis in pharmacokinetics. Eur. J. Drug Metab. Pharmacokinet. 1993, 18, 89-96.