Effect of combined fenthion and cimetidine use in rats on lethality, blood cholinesterase activities, and serum cholinesterase isoenzymes

Veterinary and Human Toxicology

Volumn 40, Issue 2, 1998, Pages 77-82

  Sakaguchi, Kazuko ^a   Akahori, Fumiaki ^a   Shirai, Mitsuyuki ^a   Masaoka, Toshio ^a   Arishima, Kazuyoshi ^a   Kounenis, G ^b  

^a AZABU UNIVERSITY   (Japan)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CIMETIDINE; FENTHION; GUM ARABIC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINESTERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; LD 50; LETHALITY; NONHUMAN; RAT; SURVIVAL RATE;

ANIMALS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CIMETIDINE; DRUG SYNERGISM; ERYTHROCYTES; FEMALE; FENTHION; GUM ARABIC; HISTAMINE H2 ANTAGONISTS; INSECTICIDES; ISOENZYMES; LETHAL DOSE 50; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031896407     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Cheah LS, Lee HS, Cwee MCE: Anticholinesterase activity and possible ion-channel block by cimetidine, ranitidine and oxmetidine in the toad isolated rectus abdominis muscle. Clin Exp Pharmacol Physiol 12: 353-357, 1985.
2. Hansen WE, Bertl S: The inhibition of acetylcholinesterase and pseudocholinesterase by cimetidine. Arzneim-Forsch/Drug Res 33: 161-163, 1983.
3. Kounenis C, Koutsoviti-Papadopoulou M, Elezoglou V: The inhibition of acetylcholinesterase by ranitidine; A study on the guinea pig ileum. J Phormacobio Dyn 9: 941-945, 1986.
4. Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou V: Effect of nizatidine and ranitidine on the d-tubocuranine neuromuscular blockade in the toad rectus abdominis muscle. Pharmcol Res 29: 155-166, 1994.
5. Sakaguchi K, Nagayama M, Masaoka T et al : Effects of fenthion, isoxathion, dichlorvos and propaphos on the serum cholinesterase isoenzyme patterns of dogs. Vet Hum Toxicol 39: 1-5, 1997.
6. Nagayama M, Akahori F, Chiwata H et al : Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat. Vet Hum Toxicol 38: 196-199, 1996.
7. Caines TB: Acute toxicity of pesticides. Toxicol Appl Pharmacol 14: 515-534, 1969.
8. Martin H, Worthing CR: Pesticide Manual, 5th Ed. The British Crop Protection Counci1, Maivern, Worcestershire, England, 1977.
9. Fukuhara Y, Emi Y, Iwanami O: Acute toxicity of cimetidine. Clinical Report (Japan) 14: 2806-2818, 1980.
10. Juul P, Leopold IH: Studies on plasma cholincstrase isozyne in glucoma. Am J Ophth 65: 527-530, 1968.
11. 2-receptor blockers. Xenobiotica 14: 399-408, 1984.
12. Joshi UM, Thronburg JE: Interactions between cimetidine, methylparathion, and parathion. J Toxicol Environ Health 19: 337-314, 1986.
13. Eto M: Organophosphorus Pesticides: Organic and Biological Chemistry CRC Press, Boca Raton, FL, 1979.
14. Kojima T, Tsuda S, Shirasu Y: Non-cholinergic mechanisms underlying the acute lethal effects of P=S type Organophosphorus insecticides in rats. J Vet Med Sci 54: 529-533, 1992.
15. Takahashi H, Kojima T, Ikeda T et al : Differences in the mode of lethality produced through intravenous and oral administration of organophosphorus insecticides in rats. Fund Appl Toxicol 16: 459-468, 1991.