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Volumn 17, Issue 4, 1998, Pages 697-709

Aldehydo-oligonucleotides for bioconjugation

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; OLIGODEOXYRIBONUCLEOTIDE; OLIGONUCLEOTIDE; PHOSPHORUS 32;

EID: 0031895425     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319808004669     Document Type: Article
Times cited : (9)

References (18)
  • 14
    • 85036601751 scopus 로고    scopus 로고
    • note
    • We took this epimer because the aldehyde function is not only suitable for coupling with supports, vectors or reporter groups, but could also be used to perform an hybridizationtriggered crosslinking with a target mRNA and so reinforce an antisense effect. For this purpose, the aldehyde function incorporated in a duplex has to point towards the amino functions of the nucleic base situated in front of him. The S epimer was considered to be more suitable than the other because it corresponds to the natural β configuration of the nucleotides.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.