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note
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We took this epimer because the aldehyde function is not only suitable for coupling with supports, vectors or reporter groups, but could also be used to perform an hybridizationtriggered crosslinking with a target mRNA and so reinforce an antisense effect. For this purpose, the aldehyde function incorporated in a duplex has to point towards the amino functions of the nucleic base situated in front of him. The S epimer was considered to be more suitable than the other because it corresponds to the natural β configuration of the nucleotides.
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