In vitro transesterification of cocaethylene (ethylcocaine) in the presence of ethanol: Esterase-mediated ethyl ester exchange

Drug Metabolism and Disposition

Volumn 26, Issue 3, 1998, Pages 203-206

  Bourland, James A ^a   Martin, Debra K ^c   Mayersohn, Michael ^b  

^a Associated Pathologists Laboratories   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HOMOCOCAINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; ENZYME ANALYSIS; ENZYME KINETICS; ESTERIFICATION; GAS CHROMATOGRAPHY; LIVER HOMOGENATE; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; COCAINE; ENZYME INHIBITORS; ESTERASES; ETHANOL; KINETICS; LIVER; MALE; NITROPHENOLS; PHYSOSTIGMINE; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM;

EID: 0031895399     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Boyer CS and Petersen DR (1992) Enzymatic basis for the transesterification of cocaine in the presence of ethanol: evidence for participation of microsomal carboxylesterases. J Pharmacol Exp Ther 260:939-946.
2. Brzenzinski MR, Abraham TL, Stone CL, Dean RA and Bosron WF (1994) Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem Pharmacol 48:1747-1755.
3. Dean RA, Christian CD, Sample RHB and Bosron WF (1991) Human liver cocaine esterases: ethanol mediated formation of ethylcocaine. FASEB J 5:2735-2739.
4. Hearn WL, Flynn DD, Hime GW, Rose S, Cofino JC, Mantero-Atienza E, Wetli CV and Mash DC (1991) Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem 56:698-701.
5. Katz JL, Terry P and Witkin JM (1992) Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl ester (cocaethylene) Life Sci 50:1351-1361.
6. Lam FC, Hung CT and Perrier DG (1985) Estimation of variance for harmonic mean half-lives. J Pharm Sci 74:229-231.
7. Woodward JJ, Mansbach R, Caroll FI and Balster RL (1991) Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies. Eur J Pharmacol 197:235-236.