Expression of p53 and p21 are independent prognostic factors in patients with serosal invasion by gastric carcinoma

Digestive Diseases and Sciences

Volumn 43, Issue 5, 1998, Pages 964-970

  Ikeguchi, Masahide ^a   Saito, Hiroaki ^a   Katano, Kuniyuki ^a   Tsujitani, Shunichi ^a   Maeta, Michio ^a   Kaibara, Nobuaki ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Gastric cancer; p21; p53; Prognostic factor

Indexed keywords

PROTEIN P21; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER INVASION; CONTROLLED STUDY; FEMALE; GASTRECTOMY; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; SEROSA; STOMACH CARCINOMA; SURVIVAL RATE; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; RETROSPECTIVE STUDIES; SEROUS MEMBRANE; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031895123     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018862214081     Document Type: Article

References (29)

1. Roder JD, Böttcher K, Siewert R, Busch R, Hermanek P, Meyer H-J, German Gastric Carcinoma Study Group: Prognostic factors in gastric carcinoma. Results of the German gastric carcinoma study 1992. Cancer 72:2089-2097, 1993
2. Shiu M, Moore E, Sanders M, Huvos A, Freedman B, Goodbold J, Chaiyaphruk S, Wesdorp R, Brennan MF: Influence of the extent of resection on survival after curative treatment of gastric carcinoma. A retrospective multivariate analysis. Arch Surg 122:1347-1351, 1987
3. Nakamura K, Ueyama T, Yao T, Xuan ZX, Ambe K, Adachi Y, Yakeishi Y, Matsukuma A, Enjoji M: Pathology and prognosis of gastric carcinoma. Findings in 10,000 patients who underwent primary gastrectomy. Cancer 70:1030-1037, 1992
4. Noguchi Y, Imada T, Matsumoto A, Goit DG, Brennan MF: Radical surgery for gastric cancer. A review of the Japanese experience. Cancer 64:2053-2062, 1989
5. Otani S, Maeta M, Oka A, Tsujitani S, Ikeguchi M, Hamazoe R, Kaibara N: Long-term survival of 5 years following initial surgery for gastric cancer and simultaneous disseminated peritoneal metastasis: Report of a case. Surg Today 25:959-961, 1995
6. Kaibara N, Nishidoi H, Kimura O, Makino M, Sumi K, Koga S: Analysis of results of surgical treatment of gastric cancer. Retrospective study of 1,215 curatively resected cases. Dig Surg 5:124-127, 1988
7. Maehara Y, Okuyama T, Oshiro T, Baba H, Adachi Y, Sugimachi K: Analysis of 390 patients surviving 10 years or longer after curative resection for gastric cancer. Oncology 51:366-371, 1994
8. Baba H, Korenaga D, Okamura T, Saito A, Sugimachi K: Prognostic factors in gastric cancer with serosal invasion. Univariate and multivariate analyses. Arch Surg 124:1061-1064, 1989
9. Starzynska T, Blomley M, Ghosh A, Stern PL: Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br J Cancer 66:558-562, 1992
10. Martin HM, Filipe MI, Morris RW, Lane DP, Silvestre F: p53 expression and prognosis in gastric carcinoma. Int J Cancer 50:859-862, 1992
11. Hurlimann J, Saraga EP: Expression of p53 protein in gastric carcinomas. Am J Surg Pathol 18:1247-1253, 1994
12. waf1/ cip1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 11:1899-1905, 1995
13. ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene 11:1487-1498, 1995
14. Cip1. Oncogene 11:1675-1683, 1995
15. Japanese Research Society for Gastric Cancer: The General Rules for the Gastric Cancer Study, First English Edition, Kanehara, Tokyo, 1995
16. Ming SC: Gastric carcinoma; a pathological classification. Cancer 39:2475-2485, 1977
17. Hsu SM, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580, 1981
18. Kawai K, Serizawa A, Hamana T, Tsutsumi Y: Heat-induced antigen retrieval of proliferating cell nuclear antigen and p53 protein in formalin-fixed, paraffin-embedded sections. Pathol Int 44:759-764, 1994
19. Finaly CA, Hinds PW, Tan TH, Eliyahu D, Oren M, Levine AJ: Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol 8:531-539, 1988
20. Shiohara M, EL-Deiry WS, Wada M, Nakamaki T, Takeuchi S, Yang R, Chen D-L, Vogelstein B, Koeffler HP: Absence of WAF1 mutation in a variety of human malignancies. Blood 84:3781-3784, 1994
21. Msika S, Chastang C, Houry S, Lacaine F, Huguier M: Lymph node involvement as the only prognostic factor in curative resected gastric carcinoma: A multivariate analysis. World J Surg 13:119-123, 1989
22. Gabbert HE, Müller W, Schneiders A, Meier S, Hommel G: The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma. Cancer 76:720-726, 1995
23. Kwon SJ, Kim GS: Prognostic significance of lymph node metastasis in advanced carcinoma of the stomach. Br J Surg 83:1600-1603, 1996
24. De Manzoni G, Verlato G, Guglielmi A, Laterza E, Genna M, Cordiano S: Prognostic significance of lymph node dissection in gastric cancer. Br J Surg 83:1604-1607, 1996
25. Hollstein MC, Metcalf RA, Welsh JA, Montesano R, Harris CC: Frequent mutation of p53 gene in human esophageal cancer. Proc Natl Acad Sci USA 87:9958-9961, 1990
26. Lundin J, Nordling S, von Boguslawsky K, Robert PJ, Haglund C: Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer. Oncology 53:104-111, 1996
27. Lim BHG, Soong R, Grieu F, Robbins PD, House AK, Iacopetta BJ: p53 accumulation and mutation are prognostic indicators of poor survival in human gastric carcinoma. Int J Cancer 69:200-204, 1996
28. 1 arrest in human cancer cells. Cancer Res 55:5187-5190, 1995
29. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D: Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54:3391-3395, 1994