Bone mineral density and composition in rat pregnancy: Effects of streptozotocin-induced diabetes mellitus and insulin replacement

Experimental Physiology

Volumn 83, Issue 2, 1998, Pages 165-174

  Tein, M S C ^a   Breen, S A ^b   Loveday, B E ^b   Devlin, H ^a   Balment, R J ^a   Boyd, R D H ^a   Sibley, C P ^a   Garland, H O ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLUCOSE; INSULIN; MAGNESIUM; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MINERAL; CALCIUM BONE LEVEL; CALCIUM HOMEOSTASIS; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; GLUCOSE BLOOD LEVEL; GROWTH PLATE; HYPERCALCIURIA; HYPERTROPHY; NONHUMAN; PREGNANCY; RAT; STREPTOZOCIN DIABETES; TRABECULAR BONE;

EID: 0031894901     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.1998.sp004099     Document Type: Article

References (28)

1. ANWANA, A. B. & GARLAND, H. O. (1990). Renal calcium and magnesium handling in experimental diabetes mellitus in the rat. Acta Endocrinologica 122, 479-486.
2. BIRDSEY, T. J., HUSAIN, S. M., GARLAND, H. O. & SIBLEY, C. P. (1995). The effect of diabetes mellitus on urinary calcium excretion in pregnant rats and their offspring. Journal of Endocrinology 145, 11-18.
3. BOHME, C., CONSCIENCE-EGLI, M., TSCHAN, T., WINTERHALTER, K. H. & BRUCKNER, P. (1992). Induction of proliferation or hypertrophy of chondrocytes in serum-free culture: The role of insulin-like growth factor-1, insulin or thyroxine. Journal of Cell Biology 116, 1035-1042.
4. BRANDI, M. L., CRESCIOLI, C., TANINI, A., FREDIANI, U., AGNUSDEI, D. & GENNARI, C. (1993). Bone endothelial cells as estrogen targets. Calcified Tissue International 53, 312-317.
5. BREEN, S. A., MILLEST, A. J., LOVEDAY, B. E., JOHNSTON, D. & WATERTON, J. C. (1996). Regional analysis of bone mineral density in the distal femur and proximal tibia using peripheral quantitative computed tomography in the rat in vivo. Calcified Tissue International 58, 449-453.
6. GOODMAN, W. G. & HORI, M. T. (1984). Diminished bone formation in experimental diabetes. Relationship to osteoid maturation and mineralization. Diabetes 33, 825-831.
7. HILL, D. J., LOGAN, A., MCGARRY, M. & DE SOUSA, D. (1992). Control of protein and matrix-molecule synthesis in isolated ovine fetal growth-plate chondrocytes by the interactions of basic fibroblast growth factor, insulin-like growth factors-I and -II, insulin and transforming growth factor-beta 1. Journal of Endocrinology 133, 363-373.
8. HOSKINS, B. & SCOTT, J. M. (1984). Evidence for a direct action of insulin to increase renal reabsorption of calcium and for an irreversible defect in renal ability to conserve calcium due to prolonged absence of insulin. Diabetes 33, 991-994.
9. 9k mRNA expression in rat placenta. Pediatric Research 35, 376-381.
10. ISHIDA, H., SEINO, Y., TAMINATO, T., USAMI, M., TAKESHITA, N., SEINO, Y., TSUTSUMI, C., MORIUCHI, S., AKIYAMA, Y., HARA, K., SUZUKI, K. & IURA, H. (1988). Circulating levels and bone contents of bone γ-carboxyglutamic acid-containing protein are decreased in streptozotocin-induced diabetes. Diabetes 37, 702-706.
11. LAZOWSKI, D. A., FRAHER, L. J., HODSMAN, A., STEER, B., MODROWSKI, D. & HAN, V. K. (1994). Regional variation of insulin-like growth factor-I gene expression in mature rat bone and cartilage Bone 15, 563-576.
12. LEHMANN, R., WAPNIARZ, M., KVASNICKA, H. M., BAEDEKER, S., KLEIN, K. & ALLOLIO, B. (1992). Reproducibility of bone density measurements of the distal radius using a high resolution special scanner for peripheral quantitative computed tomography (single energy pQCT). Radiologe 32, 177-181.
13. LETTGEN, B., HAUFFA, B., MÖHLMANN, C., JEKEN, C. & REINERS, C. (1995). Bone mineral density in children and adolescents with juvenile diabetes: selective measurement of bone mineral density of trabecular and cortical bone using peripheral quantitative computed tomography. Hormone Research 43, 173-175.
14. MCNAIR, P., CHRISTIANSEN, C., CHRISTIANSEN, M. S., MADSBAD, S., FABER, O. K., BINDER, C. & TRANSBØL, I. (1981). Development of bone mineral loss in insulin-treated diabetes: a 1 1/2 years follow-up study in sixty patients. European Journal of Clinical Investigation 11, 55-59.
15. MARCHI, F., LUDER, H. U. & LEBLOND, C. P. (1991). Changes in cells' secretory organelles and extracellular matrix during endochondral ossification in the mandibular condyle of the growing rat. American Journal of Anatomy 190, 41-73.
16. MARTIN, T. J., MOSELEY, J. M. & WILLIAMS, E. D. (1997). Parathyroid hormone-related protein: hormone and cytokine. Journal of Endocrinology 154, S23-S37.
17. RASKIN, P., STEVENSON, M. R. M., BARILLA, D. E. & PAK, C. Y. C. (1978). The hypercalciuria of diabetes mellitus : its amelioration with insulin. Clinical Endocrinology 9, 329-335.
18. ROSHOLT, M. N. & HEGARTY, P. V. (1981). Mineralization of different bones in streptozotocin-diabetic rats: study on the concentration of eight minerals. American Journal of Clinical Nutrition 34, 1680-1685.
19. SEINO, Y. & ISHIDA, H. (1995). Diabetic osteopenia: pathophysiology and clinical aspects. Diabetes/Metabolism Reviews 11, 21-35.
20. SELBY, P. L. (1988). Osteopenia and diabetes. Diabetic Medicine 5, 423-428.
21. SHIRES, R., TEITELBAUM, S. L., BERGFELD, M. A., FALLON, M. D., SLATOPOLSKY, E. & AVIOLI, L. V. (1981). The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat. Journal of Laboratory and Clinical Medicine 97, 231-240.
22. SIMECKOVA, A., STOLBA, P., HATLE, K., ZAMRAZIL, V. & NERADILOVA, M. (1990). The effect of streptozotocin-induced diabetes treated with insulin on the metabolism of calcium, magnesium and phosphorus. Vnitrní Lékarství 36, 526-530.
23. 3 on the osteopenia. Life Sciences 56, 1095-1101.
24. TEIN, M. S. C., BIRDSEY, T. J., GARLAND, H. O., BALMENT, R. J., BOYD, R. D. H. & SIBLEY, C. P. (1996a). Influence of diabetes mellitus on gestational changes in blood calcium and hormone profiles in the rat. Journal of Physiology 493.P, 85P.
25. 2+ content and bone mineral density (BMD) of pregnant rats. Journal of Physiology 497.P, 126P.
26. VERHAEGHE, J., BOUILLON, R., NYOMBA, B. L., LISSENS, W. & VAN ASSCHE, F. A. (1986). Vitamin D and bone mineral homeostasis during pregnancy in the diabetic BB rat. Endocrinology 118, 1019-1025.
27. VERHAEGHE, J., SUIKER, A. M. H., NYOMBA, B. L., VISSER, W. J., EINHORN, T. A., DEQUEKER, J. & BOUILLON, R. (1989). Bone mineral homeostasis in spontaneously diabetic BB rats. II. Impaired bone turnover and decreased osteocalcin synthesis. Endocrinology 124, 573-582.
28. VERHAEGHE, J., VAN HERCK, E., VISSER, W. J., SUIKER, A. M. H., THOMASSET, M., EINHORN, T. A., FAIERMAN, E. & BOUILLON, R. (1990). Bone and mineral metabolism in BB rats with long-term diabetes: decreased bone turnover and osteoporosis. Diabetes 39, 477-482.