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Volumn 13, Issue 3, 1998, Pages 596-603

Recombinant human follicle stimulating hormone for treatment of male idiopathic infertility: A randomized, double-blind, placebo-controlled, clinical trial

Author keywords

Electron microscopy; Male idiopathic infertility; Randomized controlled clinical trial; Recombinant human FSH; Semen parameters

Indexed keywords

DNA; FOLLITROPIN; INHIBIN; RECOMBINANT FOLLITROPIN;

EID: 0031894748     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.3.596     Document Type: Article
Times cited : (118)

References (45)
  • 1
    • 0026705266 scopus 로고
    • Pure human follicle stimulating hormone has a role in the treatment of severe male infertility by assisted reproduction: Norfolk's total experience
    • Acosta, A.A., Khalifa, E. and Oehninger, S. (1992) Pure human follicle stimulating hormone has a role in the treatment of severe male infertility by assisted reproduction: Norfolk's total experience. Hum. Reprod., 7, 1067-1072.
    • (1992) Hum. Reprod. , vol.7 , pp. 1067-1072
    • Acosta, A.A.1    Khalifa, E.2    Oehninger, S.3
  • 2
    • 0029154170 scopus 로고
    • Notulae seminologicae. 5. Mathematical evaluation of interdependent submicroscopic sperm alterations
    • Bacetti, B., Bernieri, G., Burrini, A.G. et al. (1995) Notulae seminologicae. 5. Mathematical evaluation of interdependent submicroscopic sperm alterations. J. Androl., 16, 356-371.
    • (1995) J. Androl. , vol.16 , pp. 356-371
    • Bacetti, B.1    Bernieri, G.2    Burrini, A.G.3
  • 3
    • 0027528716 scopus 로고
    • Treatment of severe male infertility with pure follicle stimulating hormone (FSH): The need for a properly controlled multicentre trial
    • Baker, G., Brindsen, P., Jouannet, P. et al. (1992) Treatment of severe male infertility with pure follicle stimulating hormone (FSH): the need for a properly controlled multicentre trial. Hum. Reprod., 8, 500-501.
    • (1992) Hum. Reprod. , vol.8 , pp. 500-501
    • Baker, G.1    Brindsen, P.2    Jouannet, P.3
  • 4
    • 0005467965 scopus 로고
    • Treatment of male factor with urofollitropin after the failure of a first attempt of in vitro fertilization (IVF)
    • Ballesca, J.L., Barri, P., Calderon, G. et al. (1995) Treatment of male factor with urofollitropin after the failure of a first attempt of in vitro fertilization (IVF). J. Assist. Reprod. Genet., 12, 167S.
    • (1995) J. Assist. Reprod. Genet. , vol.12
    • Ballesca, J.L.1    Barri, P.2    Calderon, G.3
  • 5
    • 0024605507 scopus 로고
    • Pulsatile GnRH-therapy in oligozoospermic men does not improve seminal parameters despite decreased FSH levels
    • Bals-Pratsch, M., Knuth, U.A., Hönigl, W. et al. (1989) Pulsatile GnRH-therapy in oligozoospermic men does not improve seminal parameters despite decreased FSH levels. Clin. Endocrinol., 30, 549-560.
    • (1989) Clin. Endocrinol. , vol.30 , pp. 549-560
    • Bals-Pratsch, M.1    Knuth, U.A.2    Hönigl, W.3
  • 6
    • 0028258173 scopus 로고
    • Sperm quality of subfertile males before and after treatment with follicle-stimulating hormone
    • Bartoov, B., Eltes, F. and Lunenfeld, E. (1994) Sperm quality of subfertile males before and after treatment with follicle-stimulating hormone. Fertil. Steril., 61, 727-734.
    • (1994) Fertil. Steril. , vol.61 , pp. 727-734
    • Bartoov, B.1    Eltes, F.2    Lunenfeld, E.3
  • 7
    • 84968990329 scopus 로고
    • Objective and accurate measurement of sperm concentration by flow cytometry
    • Serio, M. (ed.), Miniposters, IV International Congress of Andrology, Florence, Italy
    • Behre, H.M., Hacker-Klom, U., Göhde, W. and Nieschlag, E. (1989) Objective and accurate measurement of sperm concentration by flow cytometry. In Serio, M. (ed.), Ares-Serono Symposia Review, Supplement I, Miniposters, IV International Congress of Andrology, Florence, Italy.
    • (1989) Ares-Serono Symposia Review, Supplement I
    • Behre, H.M.1    Hacker-Klom, U.2    Göhde, W.3    Nieschlag, E.4
  • 8
    • 0024847727 scopus 로고
    • Objective measurement of testicular volume by ultrasonography: Evaluation of the technique and comparison with orchidometer estimates
    • Behre, H.M., Nashan, D. and Nieschlag, E. (1990) Objective measurement of testicular volume by ultrasonography: evaluation of the technique and comparison with orchidometer estimates. Int. J. Androl., 12, 395-403.
    • (1990) Int. J. Androl. , vol.12 , pp. 395-403
    • Behre, H.M.1    Nashan, D.2    Nieschlag, E.3
  • 9
    • 0029621088 scopus 로고
    • Clinical relevance of scrotal and transrectal ultrasonography in andrological patients
    • Behre, H.M., Kliesch, S., Schädel, F. and Nieschlag, E. (1995) Clinical relevance of scrotal and transrectal ultrasonography in andrological patients. Int. J. Androl., 18, 27-31.
    • (1995) Int. J. Androl. , vol.18 , pp. 27-31
    • Behre, H.M.1    Kliesch, S.2    Schädel, F.3    Nieschlag, E.4
  • 10
    • 0005463744 scopus 로고
    • Pure FSH (pFSH) treatment to male partners in IVF cycles due to idiopathic oligo-teratoasthenozoospermia (OTA) syndrome
    • Ben Rafael, Z., Ashkenazi, J., Farhi, J. et al. (1995) Pure FSH (pFSH) treatment to male partners in IVF cycles due to idiopathic oligo-teratoasthenozoospermia (OTA) syndrome. J. Assist. Reprod. Genet., 12, 52S.
    • (1995) J. Assist. Reprod. Genet. , vol.12
    • Ben Rafael, Z.1    Ashkenazi, J.2    Farhi, J.3
  • 13
    • 0031023464 scopus 로고    scopus 로고
    • Effects of pure human follicle-stimulating hormone (pFSH) on sperm quality correlate with the hypophyseal response to gonadotropin-releasing hormone (GnRH)
    • Glander, H.-J. and Kratzsch, J. (1997) Effects of pure human follicle-stimulating hormone (pFSH) on sperm quality correlate with the hypophyseal response to gonadotropin-releasing hormone (GnRH). Andrologia, 29, 23-28.
    • (1997) Andrologia , vol.29 , pp. 23-28
    • Glander, H.-J.1    Kratzsch, J.2
  • 14
    • 0029913238 scopus 로고    scopus 로고
    • An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man
    • Gromoll, J., Simoni, M. and Nieschlag, E. (1996) An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. J. Clin. Endocrinol. Metab., 81, 1367-1370.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1367-1370
    • Gromoll, J.1    Simoni, M.2    Nieschlag, E.3
  • 15
    • 0024462403 scopus 로고
    • Testicular enlargement and elevated serum inhibin concentrations occur in patients with pituitary macroadenomas secreting follicle stimulating hormone
    • Heseltine, D., White, M.C. Kendall-Taylor, P. et al. (1989) Testicular enlargement and elevated serum inhibin concentrations occur in patients with pituitary macroadenomas secreting follicle stimulating hormone. Clin. Endocrinol., 31, 411-423.
    • (1989) Clin. Endocrinol. , vol.31 , pp. 411-423
    • Heseltine, D.1    White, M.C.2    Kendall-Taylor, P.3
  • 16
    • 0004812292 scopus 로고    scopus 로고
    • Geneva, E6GCPD12
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) (1996) Good Clinical Practice: Consolidated Guideline. Geneva, E6GCPD12, pp. 1-71.
    • (1996) Good Clinical Practice: Consolidated Guideline , pp. 1-71
  • 17
    • 0025149548 scopus 로고
    • Bio and immunoactivity of FSH in serum after intramuscular injection of highly purified urinary human FSH in normal men
    • Jockenhövel, F., Fingscheidt, U., Khan, S.A. et al. (1990) Bio and immunoactivity of FSH in serum after intramuscular injection of highly purified urinary human FSH in normal men. Clin. Endocrinol., 33, 573-584.
    • (1990) Clin. Endocrinol. , vol.33 , pp. 573-584
    • Jockenhövel, F.1    Fingscheidt, U.2    Khan, S.A.3
  • 18
    • 0028223949 scopus 로고
    • Ineffectiveness of kallikrein in treatment of idiopathic male infertility: A double-blind, randomized, placebo-controlled trial
    • Keck, C., Behre, H.M., Jockenhövel, F. and Nieschlag, E. (1994) Ineffectiveness of kallikrein in treatment of idiopathic male infertility: a double-blind, randomized, placebo-controlled trial. Hum. Reprod., 9, 325-329.
    • (1994) Hum. Reprod. , vol.9 , pp. 325-329
    • Keck, C.1    Behre, H.M.2    Jockenhövel, F.3    Nieschlag, E.4
  • 19
    • 0027937218 scopus 로고
    • High efficacy of gonadotropin or pulsatile GnRH treatment in hypogonadotropic hypogonadal men
    • Kliesch, S., Behre, H.M. and Nieschlag, E. (1994) High efficacy of gonadotropin or pulsatile GnRH treatment in hypogonadotropic hypogonadal men. Eur. J. Endocrinol., 131, 347-354.
    • (1994) Eur. J. Endocrinol. , vol.131 , pp. 347-354
    • Kliesch, S.1    Behre, H.M.2    Nieschlag, E.3
  • 20
    • 0029025360 scopus 로고
    • Recombinant human follicle stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadal male
    • Kliesch, S., Behre, H.M. and Nieschlag, E. (1995) Recombinant human follicle stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadal male. Fertil. Steril., 62, 1326-1328.
    • (1995) Fertil. Steril. , vol.62 , pp. 1326-1328
    • Kliesch, S.1    Behre, H.M.2    Nieschlag, E.3
  • 21
    • 0023588238 scopus 로고
    • Treatment of severe oligozoospermia with HCG/HMG. A placebo-controlled double blind trial
    • Knuth, U.A., Hönigl, W., Bals-Pratsch, M. et al. (1987) Treatment of severe oligozoospermia with HCG/HMG. A placebo-controlled double blind trial. J. Clin. Endocrinol. Metab., 65, 1081-1087.
    • (1987) J. Clin. Endocrinol. Metab. , vol.65 , pp. 1081-1087
    • Knuth, U.A.1    Hönigl, W.2    Bals-Pratsch, M.3
  • 22
    • 0028329520 scopus 로고
    • Clinical pharmacology of recombinant human follicle stimulating hormone. II Single doses and steady state pharmacokinetics
    • le Cotonnec, J.Y., Porchet, H.C., Beltrami, V. et al. (1994) Clinical pharmacology of recombinant human follicle stimulating hormone. II Single doses and steady state pharmacokinetics. Fertil. Steril., 61, 679-686.
    • (1994) Fertil. Steril. , vol.61 , pp. 679-686
    • Cotonnec, J.Y.1    Porchet, H.C.2    Beltrami, V.3
  • 23
    • 0030452272 scopus 로고    scopus 로고
    • Male infertility in the light of evidence-based medicine
    • Leifke, E. and Nieschlag, E. (1996) Male infertility in the light of evidence-based medicine. Andrologia, 28, 23-30.
    • (1996) Andrologia , vol.28 , pp. 23-30
    • Leifke, E.1    Nieschlag, E.2
  • 24
    • 0025838783 scopus 로고
    • Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone
    • Mannaerts, B., de Leeuw, R., Geelen, J. et al. (1991) Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone. Endocrinology, 129, 2623-2630.
    • (1991) Endocrinology , vol.129 , pp. 2623-2630
    • Mannaerts, B.1    De Leeuw, R.2    Geelen, J.3
  • 25
    • 1842373328 scopus 로고    scopus 로고
    • Treatment of the male with follicle-stimulating hormone in intrauterine insemination with husband's spermatozoa: A randomized study
    • Matorras, R., Perez, C., Corcostegui, B. et al. (1997) Treatment of the male with follicle-stimulating hormone in intrauterine insemination with husband's spermatozoa: a randomized study. Hum. Reprod., 12, 24-28.
    • (1997) Hum. Reprod. , vol.12 , pp. 24-28
    • Matorras, R.1    Perez, C.2    Corcostegui, B.3
  • 26
    • 79961220415 scopus 로고    scopus 로고
    • Sperm characteristics and hormonal profile before and after treatment with follicle-stimulating hormone in infertile patients
    • Merino, G., Carranza-Lira, S., Martinez-Chequer, J.C. et al. (1996) Sperm characteristics and hormonal profile before and after treatment with follicle-stimulating hormone in infertile patients. Arch. Androl., 37, 197-200.
    • (1996) Arch. Androl. , vol.37 , pp. 197-200
    • Merino, G.1    Carranza-Lira, S.2    Martinez-Chequer, J.C.3
  • 28
    • 0025604562 scopus 로고
    • '9 + 0 axoneme in spermatozoa and some nasal cilia of a patient with totally immotile spermatozoa associated with thickened sheath and short midpiece
    • Neugebauer, D.C., Neuwinger, J., Jockenhövel, F. and Nieschlag, E. (1990) '9 + 0 axoneme in spermatozoa and some nasal cilia of a patient with totally immotile spermatozoa associated with thickened sheath and short midpiece. Hum. Reprod., 5, 981-986.
    • (1990) Hum. Reprod. , vol.5 , pp. 981-986
    • Neugebauer, D.C.1    Neuwinger, J.2    Jockenhövel, F.3    Nieschlag, E.4
  • 29
    • 0025158279 scopus 로고
    • External quality control in the andrology laboratory: An experimental multicenter trial
    • Neuwinger, J., Behre, H.M. and Nieschlag, E. (1990) External quality control in the andrology laboratory: an experimental multicenter trial. Fertil. Steril., 54, 308-314.
    • (1990) Fertil. Steril. , vol.54 , pp. 308-314
    • Neuwinger, J.1    Behre, H.M.2    Nieschlag, E.3
  • 30
    • 0002591832 scopus 로고    scopus 로고
    • Empirical therapies for idiopathic infertility
    • Nieschlag, E. and Behre, H.M. (eds), Springer, Heidelberg
    • Nieschlag, E. and Leifke, E. (1997) Empirical therapies for idiopathic infertility. In Nieschlag, E. and Behre, H.M. (eds), Andrology: Male Reproductive Health and Dysfunction. Springer, Heidelberg, pp. 313-319.
    • (1997) Andrology: Male Reproductive Health and Dysfunction , pp. 313-319
    • Nieschlag, E.1    Leifke, E.2
  • 31
    • 0003642838 scopus 로고
    • OECD, Paris, Environment monograph No. 45
    • Organization for Economic Co-operation and Development (OECD) (1992) The OECD Principles of Good Laboratory Practice. OECD, Paris, Environment monograph No. 45.
    • (1992) The OECD Principles of Good Laboratory Practice
  • 32
    • 0005510421 scopus 로고
    • Follicle-stimulating hormone (pFSH) treatment for male factor infertility with previous failed fertilization in vitro
    • Ranieri, M., Sturdy, J., Marchant, S. et al. (1994). Follicle-stimulating hormone (pFSH) treatment for male factor infertility with previous failed fertilization in vitro. Hum. Reprod., 3, 19.
    • (1994) Hum. Reprod. , vol.3 , pp. 19
    • Ranieri, M.1    Sturdy, J.2    Marchant, S.3
  • 33
    • 0005492240 scopus 로고    scopus 로고
    • Tamoxifen bei männlicher Infertilität: Analyse einer fragwürdigen Therapie
    • Rolf, C., Behre, H.M. and Nieschlag, E. (1996) Tamoxifen bei männlicher Infertilität: Analyse einer fragwürdigen Therapie. Dtsch. Med. Wsch., 121, 33-39.
    • (1996) Dtsch. Med. Wsch. , vol.121 , pp. 33-39
    • Rolf, C.1    Behre, H.M.2    Nieschlag, E.3
  • 34
    • 0005430729 scopus 로고
    • Improvement of sperm concentration and bovine mucus penetration in idiopathic oligozoospermia by administration of pure FSH
    • Sigg, C. and Baciu, M. (1994) Improvement of sperm concentration and bovine mucus penetration in idiopathic oligozoospermia by administration of pure FSH. Hum. Reprod., 9 (suppl. 4), 47.
    • (1994) Hum. Reprod. , vol.9 , Issue.SUPPL. 4 , pp. 47
    • Sigg, C.1    Baciu, M.2
  • 35
    • 0029590015 scopus 로고
    • FSH in therapy: Physiological basis, new preparations and clinical use
    • Simoni M. and Nieschlag E. (1995) FSH in therapy: physiological basis, new preparations and clinical use. Reprod. Med. Rev., 4, 163-177.
    • (1995) Reprod. Med. Rev. , vol.4 , pp. 163-177
    • Simoni, M.1    Nieschlag, E.2
  • 36
    • 0030830648 scopus 로고    scopus 로고
    • The effect of follicle-stimulating hormone therapy on sperm quality: An ultrastructural mathematical evaluation
    • Strehler, E., Sterzik, K., De Santo, M. et al. (1997) The effect of follicle-stimulating hormone therapy on sperm quality: an ultrastructural mathematical evaluation. Androl. 18, 439-447.
    • (1997) Androl. 18 , pp. 439-447
    • Strehler, E.1    Sterzik, K.2    De Santo, M.3
  • 37
    • 0023714288 scopus 로고
    • Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey
    • van Alphen, M.M.A., van de Kant, H.J.G. and de Rooij, D.G. (1988) Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. Endocrinology, 123, 1449-1455.
    • (1988) Endocrinology , vol.123 , pp. 1449-1455
    • Van Alphen, M.M.A.1    Van de Kant, H.J.G.2    De Rooij, D.G.3
  • 38
    • 0141882042 scopus 로고    scopus 로고
    • Kinin enhancing drugs for male infertility
    • Lilford R., Hughes, E. and Vandekerckhove, P. (eds), Cochrane Library. The Cochrane Collaboration, Issue 2, updated July 1995. Update Software, Oxford
    • Vandekerckhove, P., Lilford, R. and Hughes, E. (1995) Kinin enhancing drugs for male infertility. In Lilford R., Hughes, E. and Vandekerckhove, P. (eds), Subfertility Module of the Cochrane Database of Systematic Reviews. Cochrane Library. The Cochrane Collaboration, Issue 2, updated July 1995. Update Software, Oxford.
    • (1995) Subfertility Module of the Cochrane Database of Systematic Reviews
    • Vandekerckhove, P.1    Lilford, R.2    Hughes, E.3
  • 39
    • 0141882042 scopus 로고    scopus 로고
    • The medical treatment of idiopathic oligo/asthenospermia: Androgens (mesterolone or testosterone) versus placebo or no treatment
    • Lilford R., Hughes, E. and Vandekerckhove, P. (eds), Cochrane Library. The Cochrane Collaboration, Issue 2, updated March 1996, Update Software, Oxford
    • Vandekerckhove, P., Lilford, R. and Hughes, E. 1996) The medical treatment of idiopathic oligo/asthenospermia: androgens (mesterolone or testosterone) versus placebo or no treatment. In Lilford R., Hughes, E. and Vandekerckhove, P. (eds), Subfertility Module of the Cochrane Database of Systematic Reviews. Cochrane Library. The Cochrane Collaboration, Issue 2, updated March 1996, Update Software, Oxford.
    • (1996) Subfertility Module of the Cochrane Database of Systematic Reviews
    • Vandekerckhove, P.1    Lilford, R.2    Hughes, E.3
  • 40
    • 0005492241 scopus 로고
    • Human FSH transiently stimulates size and spermatogenesis in the adult intact non-human primate
    • Weinbauer, G.F., Behre, H.M. and Nieschlag, E. (1992) Human FSH transiently stimulates size and spermatogenesis in the adult intact non-human primate. Acta Endocrinol., 126, 97.
    • (1992) Acta Endocrinol. , vol.126 , pp. 97
    • Weinbauer, G.F.1    Behre, H.M.2    Nieschlag, E.3
  • 43
    • 84989656830 scopus 로고
    • A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility
    • World Health Organization (WHO) Special Programme of Research, Development and Research Training in Human Reproduction, Task Force on the Prevention and Management of Infertility (1992b) A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility. Int. J. Androl., 15, 299-307.
    • (1992) Int. J. Androl. , vol.15 , pp. 299-307


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