Distribution and stability of antisense phosphorothioate oligonucleotides in rodent brain following direct intraparenchymal controlled-rate infusion

Journal of Neurosurgery

Volumn 88, Issue 4, 1998, Pages 734-742

  Broaddus, William C ^a   Prabhu, Sujit S ^b   Gillies, George T ^b   Neal, Jeffrey ^b   Condad, William S ^b   Chen, Zhi Jian ^b   Fillmore, Helen ^b   Young, Harold F ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Antisense oligonucleotide; Autoradiography; Gel electrophoresis; High flow microinfusion

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BLOOD BRAIN BARRIER; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; GEL ELECTROPHORESIS; GENE TARGETING; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; RAT; TISSUE DISTRIBUTION;

EID: 0031894204     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1998.88.4.0734     Document Type: Article

References (33)

1. Agrawal S, Ikeuchi T, Sun D, et al: Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues. Proc Natl Acad Svi USA 86:7790-7794, 1989
2. Agrawal S, Iyer RP: Modified oligonucleotides as therapeutic and diagnostic agents. Curr Opin Biotechnol 6:12-19, 1995
3. Agrawal S, Temsamani J, Tang JY: Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc Natl Acad Sci USA 88:7595-7599, 1991
4. Agrawal S, Zhang X, Lu Z, et al: Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration. Biochem Pharmacol 50: 571-576, 1995
5. Bacon TA, Morvan F, Rayner B, et al: Alpha-oligodeoxynucleotide stability in serum, subcellular extracts and culture media. J Biochem Biophys Methods 16:311-318, 1988
6. Bakay L: The extracellular space in brain tumours I. Morphological considerations. Brain 93:693-698, 1970
7. Bakay L: The extracellular space in brain tumours II. The sucrose space. Brain 93:699-708, 1970
8. Blasberg RG, Patlak C, Fenstermacher JD: Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. J Pharmacol Exp Ther 195:73-83, 1975
9. Bobo RH, Laske DW, Akbasak A, et al: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91:2076-2080, 1994
10. Broaddus WC, Chen ZJ, Prabhu SS, et al: Antiproliferative effect of c-myc antisense phosphorothioate oligodeoxynucleotides in malignant glioma cells. Neurosurgery 41:908-915, 1997
11. Broaddus WC, Prabhu SS, Chen ZJ, et al: High-flow microinfusion of c-myc antisense oligonucleotides prolongs survival in an animal model of intracranial malignant glioma. Neurosurgery 39:647, 1996
12. Campbell JM, Bacon TA, Wickstrom E: Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid. J Biochem Biophys Meth 20: 259-267, 1990
13. Chiasson BJ, Armstrong JN, Hooper ML, et al: The application of antisense oligonucleotide technology to the brain: some pitfalls. Cell Mol Neurobiol 14:507-521, 1994
14. Froehler BC: Oligodeoxynucleotide synthesis. H-phosphonate approach, in Agrawal S (ed): Molecular Biology: Protocols for Oligonucleotides and Analogs, Synthesis and Properties. Totowa, NJ: Humana Press, 1993, pp 63-80
15. Goodarzi G, Watabe M, Watabe K: Organ distribution and stability of phosphorothioated oligodeoxyribonucleotides in mice. Biopharm Drug Dispos 13:221-227, 1992
16. Iversen PL, Mata J, Tracewell WG, et al: Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion. Antisense Res Dev 4:43-52, 1994
17. Jain RK: Transport of molecules in the tumor interstitium: a review. Cancer Res 47:3039-3051, 1987
18. Lieberman DM, Laske DW, Morrison PF, et al: Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82:1021-1029, 1995
19. Maltese JY, Sharma HW, Vassilev L, et al: Sequence context of antisense RelA/NF-B phosphorothioates determines specificity. Nucl Acids Res 23:1146-1151, 1995
20. Marmarou A, Hochwald G, Nakamura T, et al: Brain edema resolution by CSF pathways and brain vasculature in cats. Am J Physiol 267:H514-H520, 1994
21. Marmarou A, Tanaka K, Shulman K: The brain response to infusion edema, in Hartmann A, Brock M (eds): Treatment of Cerebral Edema. Berlin: Springer-Verlag, 1982, pp 11-18
22. Metelev V, Lisziewicz I, Agrawal S: Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyl-oligoribonucleotides. Bioorg Med Chem Lett 4:2929-2934, 1994
23. Morrison PF, Laske DW, Bobo H, et al: High-flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol 266:R292-R305, 1994
24. Prabhu SS, Broaddus WC, Gillies GT, et al: Distribution of macromolecular dyes in brain using positive pressure perfusion: a model for direct controlled delivery of therapeutic agents. Surg Neurol (In press, 1998)
25. Rapoport SI: Blood-Brain Barrier in Physiology and Medicine. New York: Raven Press, 1976, pp 99-111
26. Saijo Y, Perlaky L, Wang H, et al: Pharmacokinetics, tissue distribution, and stability of antisense oligodeoxynucleotide phophorothioate ISIS 3466 in mice. Oncol Res 6:243-249, 1994
27. Stein CA, Cheng YC: Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261:1004-1012, 1993
28. Wagner RW, Matteucci MD, Lewis JG, et al: Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science 260:1510-1513, 1993
29. Walstra G, Takagi H, Marmarou A, et al: The time course of brain tissue compliance and resistance in a controlled model of brain edema, in Shulman K, Marmarou A, Miller JD (eds): Intracranial Pressure IV. Berlin: Springer-Verlag, 1980, pp 253-256
30. Weller RO, Kida S, Zhang ET: Pathways of fluid drainage from the brain-morphological aspects and immunological significance in rat and man Brain Pathol 2:277-284, 1992
31. Whitesell L, Geselowitz D, Chavany C, et al: Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. Proc Natl Acad Sci USA 90:4665-4669, 1993
32. Zhang ET, Richards HK, Kida S, et al: Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain. Acta Neuropathol 83:233-239, 1992
33. Zhang R, Lu Z, Zhao H, et al: In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats. Biochem Pharmacol 50:545-556, 1995