Effects of the prolonged administration of selective ET(A)- and ET(B)-receptor antagonists on the rat adrenal cortex

Biomedical Research

Volumn 19, Issue 1, 1998, Pages 21-25

  Malendowicz, Ludwik K ^a   Nussdorfer, Gastone G ^b,c   Rebuffat, Piera ^b   Hochól, Anna ^a   Nowak, Magdalena ^a   Majchrzak, Mariola ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; CORTICOSTERONE; CORTICOTROPIN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE;

ADRENAL CORTEX; ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; FEMALE; GROWTH; HYPOPHYSIS ADRENAL SYSTEM; NONHUMAN; RAT; RECEPTOR OCCUPANCY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; PAA;

EID: 0031893138     PISSN: 03886107     EISSN: None     Source Type: Journal    
DOI: 10.2220/biomedres.19.21     Document Type: Article

References (11)

1. MALENDOWICZ L. K. (1987) Sex differences in adrenocortical structure and function. XXIV. Comparative morphometric studies on adrenal cortex of intact mature male and female rats of different strains. Cell Tissue Res. 249, 443-450
2. MALENDOWICZ L. K., ANDREIS P. G., NUSSDORFER G. G. and MARKOWSKA A. (1996) The possible role of endogenous substance P in the modulation of the response of rat pituitary-adrenal axis to stresses. Endocrine Res. 22, 311-318
3. B receptor subtypes. Biomedical Res. 18, 461-464
4. MALENDOWICZ L. K., NUSSDORFER G. G., MENEGHELLI V., NOWAK M., MARKOWSKA A. and MAJCHRZAK M. (1997) Effects of endothelin-1 on the rat pituitary-adrenocortical axis under basal and stressful conditions. Endocrine Res. (in press)
5. MAZZOCCHI G., REBUFFAT P., MENEGHELLI V., MALENDOWICZ L. K., KASPRZAK A. and NUSSDORFER G. G. (1990) Effects of prolonged infusion with endothelin-1 on the function and morphology of rat adrenal cortex. Peptides 11, 767-772
6. MAZZOCCHI G., ROSSI G. P., REBUFFAT P., MALENDOWICZ L. K., MARKOWSKA A. and NUSSDORFER G. G. (1997) Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in the rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways. Endocrinology 138, 2333-2337
7. NUSSDORFER G. G., ROSSI G. P. and BELLONI A. S. (1997) The role of endothelins in the paracrine control of the secretion and growth of the adrenal cortex. Int. Rev. Cytol. 171, 267-308
8. OHLSTEIN E. H., ELLIOTT J. D., FEUERSTEIN G. Z. and RUFFOLO R. R. (1996) Endothelin receptors: Receptor classification, novel receptor antagonists, and potential therapeutic targets. Med. Res. Rev. 16, 365-390
9. RUBANYI G. M. and POLOKOFF M. A. (1994) Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46, 325-415
10. STOJILKOVIC S. S. and CATT K. J. (1996) Expression and signal tansduction pathways of endothelin receptors in neuroendocrine cells. Front. Neuroendocrinol 17, 327-369
11. WEIBEL E. R. (1979) Stereological Methods. 1. Practical Methods for Biological Morphometry. Academic Press, London