A rapid novel derivatization of amphetamine and methamphetamine using 2,2,2-trichloroethyl chloroformate for gas chromatography electron ionization and chemical ionization mass spectrometric analysis

American Journal of Clinical Pathology

Volumn 109, Issue 5, 1998, Pages 527-532

  Dasgupta, Amitava ^a   Spies, Jessica ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

2,2,2 Trichloroethyl chloroformate; Amphetamine; Gas chromatography mass spectrometry; Methamphetamine

Indexed keywords

AMPHETAMINE; CENTRAL STIMULANT AGENT; CHLOROFORMIC ACID ETHYL ESTER; METHAMPHETAMINE;

ANALYTIC METHOD; ARTICLE; DERIVATIZATION; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SCREENING; DRUG URINE LEVEL; GAS CHROMATOGRAPHY; LABORATORY DIAGNOSIS; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 0031893004     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/109.5.527     Document Type: Article

References (12)

1. Jaffe JH. Drug addiction and drug abuse. In: Gilman AG, Goodman IS, Gilman L. eds. The Pharmacological Basis of Therapeutics. 6th ed. New York, NY: Macmillan; 1980:535-584.
2. Litovitz T. Amphetamines. In: Haddad L, Winchester JF, eds. Clinical Management of Poisoning and Drug Overdose. Philadelphia, Pa: Saunders; 1983:469-475.
3. Adjuntantis G. Coutselinis A, Dimopoulous G. Fatal intoxication with amphetamines. Med Sci Law. 1975;15:62-63.
4. Jonsson J, Kronstrand R, Hatanpaa M. A convenient derivatization method for the determination of amphetamine and related drugs in urine. J Forensic Sci. 1996;41:148-151.
5. Hornbeck CL, Czarny RJ. Quantitation of methamphetamine and amphetamine in urine by capillary GC/MS, part I: advantage of trichloroacetyl derivatization. J Anal Toxicol. 1989;13:144-149.
6. Czarny RJ, Hornbeck CL. Quantitation of methamphetamine and amphetamine in urine by capillary GC/MS, part II: derivatization with 4-carbethoxyhexafluorobutyryl chloride. J Anal Toxicol. 1989;13:257-262.
7. Jones JB, Mell LD. A simple wash procedure for improving chromatography of HFAA derivatized amphetamine extracts for GC/MS analysis. J Anal Toxicol. 1993;17:447.
8. Gjerde H, Hasvold I, Pettersen G, et al. Determination of amphetamine and methamphetamine in blood by derivatization with perfluorooctanoyl chloride and gas chromatography/mass spectrometry. J Anal Toxicol. 1993;17:65-68.
9. Thompson WC, Dasgupta A. Microwave induced rapid preparation of fluoro derivatives of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine for GC/MS confirmation assay. Clin Chem. 1994;40:1703-1706.
10. Gan BK, Baugh D, Liu R, et al. Simultaneous analysis of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in urine samples by solid phase extraction, derivatization and gas chromatography/mass spectrometry. J Forensic Sci. 1991;36:1331-1341.
11. Garriott JC, Soruill FG. Detection of methamphetamine in a newborn infant. J Forensic Sci. 1973;18:434-436.
12. Finkle BS, McCloskey KL, Kopjak L, et al. Toxicological analysis in cases of sudden infant death: a national feasibility study. J Forensic Sci. 1979;24:775-789.