α-Fluoro-β-alanine in urine of workers occupationally exposed to 5- fluorouracil in a 5-fluorouracil-producing factory

Biomarkers

Volumn 3, Issue 1, 1998, Pages 81-87

  Bos, R P ^a   Weissenberger, B F J ^b   Anzion, R B M ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

5 fluorouracil; Antineoplastic agents; Biological monitoring; Cytostatic drugs; Occupational exposure

Indexed keywords

ALPHA FLUORO BETA ALANINE; FLUOROURACIL;

AIR SAMPLING; ARTICLE; DRUG MANUFACTURE; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; WORKPLACE;

EID: 0031891654     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/135475098231390     Document Type: Article

References (12)

1. 19F Nuclear Magnetic Resonance. Clinical Chemistry, 31, 846-848.
2. BOLEIJ, J. S. M., BURINGH, E., HEEDERIK, D. and KROMHOUT, H. 1995, Occupational Hygiene of Chemical and Biological Agents (Amsterdam, Tokyo: Elsevier), pp. 242-253.
3. Bos, R. P. and SESSINK, P. J. M. 1997, Biomonitoring of occupational exposure to cytostatic anticancer drugs. Reviews on Environmental Health, 12, 43-58.
4. IARC 1981, Monographs on the evaluation of carcinogenic risks to humans. Vol. 26. Some antineoplastic and immunosuppressive agents (Lyon, France: International Agency for Research on Cancer).
5. IARC 1987a, Monographs on the evaluation of carcinogenic risks to humans. Suppl. 6 Genetic and related effects: an updating of selected IARC monographs from volumes 1 to 42 (Lyon, France: International Agency for Research on Cancer).
6. IARC 1987b, Monographs on the evaluation of carcinogenic risks to humans. Suppl. 7. Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42 (Lyon, France: International Agency for Research on Cancer).
7. SCHALLENBERG, E. E. and CALVIN, M. 1955, Ethyl thiotrifluoracetate as an acetylating agent with particular reference to peptide synthesis, Journal of the American Chemical Society, 77, 2779.
8. SESSINK, P. J. M., BOER, K. A., SCHEEFHALS, A. P. H., ANZION, R. B. M. and Bos, R. P. 1992, Occupational exposure to antineoplastic agents at several departments in a hospital. Environmental contamination and excretion of cyclophosphamide and ifosfamide in urine of exposed workers. International Archives of Occupational and Environmental Health, 64, 105-112.
9. SESSINK, P. J. M., SCHOLTES, M. M., ANZION, R. B. M. and Bos, R. P. 1993, Determination of cyclophosphamide in urine by gas chromatography-mass spectrometry. Journal of Chromatography, 616, 333-337.
10. SESSINK, P. J. M., FRIEMÈL, N. S. S , ANZION, R. B. M. and Bos, R. P. 1994a, Biological and environmental monitoring of occupational exposure of pharmaceutical plant workers to methotrexate. International Archives of Occupational and Environmental Health, 65, 401-403.
11. SESSINK, P. J. M., TIMMERMANS, J. L., ANZION, R. B. M. and Bos, R. P. 1994b, Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil. Determination of α-fluoro-β-alanine in urine, Journal of Occupational Medicine, 36, 79-83.
12. 18F-5-fluorouracil. International Journal of Nuclear and Medical Biology, 9, 25-35.