Baseline level and early suppression of serum HCV RNA for predicting sustained complete response to alpha-interferon therapy

Journal of Medical Virology

Volumn 54, Issue 2, 1998, Pages 86-91

  Izopet, Jacques ^a   Payen, Jean Louis ^a   Alric, Laurent ^a   Sandres, Karine ^a   Charlet, Jean Paul ^b   Vinel, Jean Pierre ^a   Duffaut, Michel ^a   Pascal, Jean Pierre ^a   Puel, Jacqueline ^a  

^a CHU PURPAN   (France)

^b Service d'Epidémiologie   (France)

Author keywords

Alpha interferon; Chronic hepatitis C; HCV genotype; HCV RNA quantification

Indexed keywords

ALANINE AMINOTRANSFERASE; RECOMBINANT ALPHA2A INTERFERON; VIRUS RNA;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; STATISTICS; VIRUS LOAD;

ADULT; AGED; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; RNA, VIRAL; TREATMENT OUTCOME;

EID: 0031891408     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199802)54:2<86::AID-JMV3>3.0.CO;2-K     Document Type: Article

References (27)

1. Chemello L, Cavalletto L, Casarin C, Bonetti P, Bernardinello E, Pontisso P, Donada C, Belussi F, Martinelli S, Alberti A, the TriVeneto Viral Hepatitis Group (1996): Persistent hepatitis C viremia predicts late relapse after sustained response to interferon-α in chronic hepatitis C. Annals of Internal Medicine 124:1058-1060.
2. Detmer J, Lagier R, Flynn J, Zayati C, Kolberg J, Collins M, Urdea M, Sanchez-Pescador R (1996): Accurate quantification of hepatitis C virus (HCV) RNA from all HCV genotypes by using branched-DNA technology. Journal of Clinical Microbiology 34:901-907.
3. Hagiwara H, Hayashi N, Mita E, Takehara T, Kasahara A, Fusamoto H, Kamada T (1993): Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy. Gastroenterology 104:877-883.
4. Hoofnagle JH (1994): Therapy of acute and chronic viral hepatitis. Advances in Internal Medicine 39:241-275.
5. Hoofnagle JH, Lau D (1996): Chronic viral hepatitis - Benefits of current therapies. New England Journal of Medicine 334:1470-1471.
6. Izopet J, Payen JL, Zarski JP, Seigneurin JM, Dussaix E, Langlois C, Sayada C, Dubois M, Alric L, Barange K, Vinel JP, Pascal JP, Fuel J, le Groupe d'étude et de traitement du virus de l'hépatite C (GET-VHC) (1996): Quantification of hepatitis C virus RNA by RT-PCR: Multicentre quality check [abstract]. Hepatology 24: 385A.
7. Kasahara A, Hayashi N, Hiramatsu N, Oshita M, Higiwara H, Katayama K, Kato M, Masuzawa M, Yoshihara H, Kishida Y, Shimizu Y, Inoue A, Fusamoto H, Kamada T (1995): Ability of prolonged interferon treatment to suppress relapse after cessation of therapy in patients with chronic hepatitis C: A multicenter randomized controlled trial. Hepatology 21:291-297.
8. Kohara M, Tanaka T, Tsukiyama-Kohara K, Tanaka S, Mizokami M, Lau JYN, Hattori N (1995): Hepatitis C virus genotypes 1 and 2 respond to interferon-α with different virologie kinetics. Journal of Infectious Diseases 172:934-938.
9. Lau JYN, Davis GL, Kniffen J, Qian K, Urdea MS, Chan CS, Mizokami M, Neuwald PD, Wilber JC (1993): Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 341:1501-1504.
10. Lau JYN, Simmonds P, Urdea MS (1995): Implications of variations of conserved regions of hepatitis C virus genome. Lancet 346:425-426.
11. Lau JYN, Davis GL, Prescott LE, Maertens G, Lindsay KL, Qian K, Mizokami M, Simmonds P, Hepatitis Interventional Therapy Group (1996): Distribution of hepatitis C virus genotypes determined by line probe assay in patients with chronic hepatitis C seen at tertiary referral centers in the United States. Annals of Internal Medicine 124:868-876.
12. Magrin S, Craxi A, Fabiano C, Simonetti RG, Fiorentino G, Marino L, Diquattro O, Di Marco V, Loiacono O, Volpes R, Almasio P, Urdea MS, Neuwald P, Sanchez-Pescador R, Detmer J, Wilber JC, Pagliaro L (1994): Hepatitis C viremia in chronic liver disease: Relationship to interferon-α or corticosteroid treatment. Hepatology 19:273-279.
13. Mantel N, Haenszel W (1959): Statistical aspects of the analysis of data from retrospective studies of disease. Journal of National Cancer Institute 22:719-748.
14. Martinot-Peignoux M, Marcellin P, Pouteau M, Castelnau C, Boyer N, Poliquin M, Degott C, Descombes I, Le Breton V, Milotova V, Benhamou JP, Erlinger S (1995): Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to Interferon Alfa therapy in chronic hepatitis C. Hepatology 22:1050-1056.
15. Ohno T, Lau JYN (1996): The "gold standard" accuracy, and the current concepts: Hepatitis C virus genotype and viremia. Hepatology 24:1312-1315.
16. Orito E, Mizokami M, Nakano T, Terashima H, Nojiri O, Sakakibara K, Mizuno M, Ogino M, Nakamura M, Matsumoto Y, Miyata K, Lau JYN (1994): Serum hepatitis C virus RNA levels as a predictor of subsequent response to interferon-α therapy in Japanese patients with chronic hepatitis C. Journal of Medical Virology 44: 410-414.
17. Pawlotsky JM, Roudot-Thoraval F, Bastie A, Darthuy F, Rémiré J, Métreau JM, Zafrani E, Duval J, Dhumeaux D (1996): Factors affecting treatment responses to interferon-α in chronic hepatitis C. Journal of Infectious Diseases 174:1-7.
18. Shindo M, Arai K, Sokama Y, Okuno T (1995): Hepatic hepatitis C virus RNA as a predictor of a long-term response to interferon-α therapy. Annals of Internal Medicine 122:586-591.
19. Simmonds P, Alberti A, Alter HJ, Bonino F, Bradley DW, Brechot C, Brouwer JT, Chan S, Chamaya K, Chen D, Choo Q, Colombo M, Cuypers HTM, Date T, Dusheiko GM, Esteban JI, Fay O, Hadziyannis SJ, Han J, Hatzakis A, Holmes EC, Hotta H, Houghton M, Irvine B, Kohara M, Kolberg JA, Kuo G, Lau JYN, Lelie PN, Maertens G, McOmish F, Miyamura T, Mizokami M, Nomoto A, Prince AM, Reesink HW, Rice C, Roggendorf M, Schalm SW, Shikata T, Shimotohno K, Stuyver L, Trepo C, Weiner A, Yap PL, Urdea MS (1994): A proposed system for the nomenclature of viral hepatitis C viral genotypes. Hepatology 19:1321-1324.
20. Smith DB, Davidson F, Yap P, Brown H, Kolberg J, Detmer J, Urdea M, Simmonds P, International HCV Collaborative Study Group (1996): Levels of hepatitis C virus in blood donors infected with different viral genotypes. Journal of Infectious Diseases 173:727-730.
21. Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght V, Van Heuverswyn, Maertens G (1993): Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. Journal of General Virology 74:1093-1102.
22. Tong MJ, El-Farra NS, Reikes AR, Co RL (1995): Clinical outcomes after transfusion-associated hepatitis C. New England Journal of Medicine 332:1463-1466.
23. Tsubota A, Chayama K, Ikeda K, Yasuji A, Koida I, Saitoh S, Hashimoto M, Iwasaki S, Kobayashi M, Hiromitsu K (1994): Factors predictive of response to interferon-α therapy in hepatitis C virus infection. Hepatology 19:1088-1094.
24. Yamada G, Takatani M, Kishi F, Takahashi M, Doi T, Tsuji T, Shin S, Tanno M, Urdea MS, Kolberg JA (1995): Efficacy of Interferon Alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level. Hepatology 22:1351-1354.
25. Yoshioka K, Kakumu S, Wakita T, Ishikawa T, Itoh Y, Takayanagi M, Higashi Y, Shibata M, Morishima T (1992): Detection of hepatitis C virus by polymerase chain reaction and response to interferon-α therapy: Relationship to genotypes of hepatitis C virus. Hepatology 16:293-299.
26. Young KK, Resnick RM, Myers TW (1993): Detection of hepatitis C virus RNA by a combined reverse transcriptase-polymerase chain reaction assay. Journal of Clinical Microbiology 31:882-886.
27. Zeuzem S, Franke A, Lee J, Herrmann G, Rüster B, Roth WK (1996): Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology. Hepatology 24:1003-1009.