Relationship between steady-state activation and availability of cardiac sodium channel: Evidence of uncoupling

Cellular and Molecular Life Sciences

Volumn 54, Issue 2, 1998, Pages 148-151

  Maltsev, V A ^a   Undrovinas, A I ^a  

^a Division of Cardiovascular Medicine   (United States)

Author keywords

Patch clamp; Rat ventricular cardiomyocytes; Sodium current availability and activation

Indexed keywords

SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONDUCTANCE; ELECTRIC POTENTIAL; HEART; MUSCLE CELL; NONHUMAN; RAT; SODIUM CURRENT; STEADY STATE;

ANIMALS; CELLS, CULTURED; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; HEART VENTRICLES; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; SODIUM CHANNELS;

ANIMALIA;

EID: 0031891247     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050135     Document Type: Article

References (14)

1. Wendt D. J., Starmer C. F. and Grant A. O. (1992) Na channel kinetics remain stable during perforated-patch recordings. Am. J. Physiol. 263: C1234-C1240
2. + current in single canine cardiac Purkinje cells. Am. J. Physiol. 262: H1197-H1207
3. Berman M. F., Camardo J. S., Robinson R. B. and Siegelbaum S. A. (1989) Single sodium channels from canine ventricular myocytes: voltage dependence and relative rates of activation and inactivation. J. Physiol. (Lond.) 415: 503-531
4. Maltsev V. A. and Undrovinas A. I. (1997) Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel. Am. J. Physiol. 273: H1832-H1840
5. Wang D. W., George A. L. and Bennett P. B. (1996) Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels. Biophys. J. 70: 283-245
6. Undrovinas A. I., Shander G. S. and Makielski J. C. (1995) Cytoskeleton modulates gating of voltage-dependent sodium channel in heart. Am. J. Physiol. 269: H203-H214
7. Hammil O. P., Marty A., Neher E., Sakmann B. and Sigworth J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391: 85-100
8. + channel action. Biophys. J. (Abstract) 72: A116
9. Chahine M., George A. L. Jr, Zhou M., Ji S., Sun W., Barchi R. L. et al. (1994) Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron 12: 281-294
10. +-channel inactivation. Proc. Natl. Acad. Sci. USA 89: 10910-10914
11. Sunami A., Fan Z., Nakamura F., Naka M., Tanaka T., Sawanobori T. et al. (1991) The catalytic subunit of cyclic AMP-dependent protein kinase directly inhibits sodium channel activities in guinea-pig ventricular myocytes. Pflugers Arch. 419: 415-417
12. Undrovinas A. I., Fleidervish I. A. and Makielski J. C. (1992) Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ. Res. 71: 1231-1241
13. Antzelevitch C, Sicouri S., Litovsky S. H., Lukas A., Krishnan S. C., Di Diego J. M. et al. (1991) Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial and M cells. Circ. Res. 69: 1427-1449
14. K,s in electrical heterogeneity. Am. J. Physiol. 268: H604-H613