Prolonged macrophage activation and persistent anaemia in children with complicated malaria

Tropical Medicine and International Health

Volumn 3, Issue 1, 1998, Pages 60-65

  Biemba, G ^a   Gordeuk, V R ^b   Thuma, P E ^c   Mabeza, G F ^a   Weiss, G ^d  

^a Macha Mission Hospital   (Zambia)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Anaemia; Interleukin 4; Malaria; Neopterin; Zambia

Indexed keywords

ANTIMALARIAL AGENT; GAMMA INTERFERON; INTERLEUKIN 4; NEOPTERIN;

ANAEMIA; CHILD HEALTH; IMMUNE ACTIVATION; MALARIA;

ANEMIA; ANTIMICROBIAL ACTIVITY; ARTICLE; CHILD; CLINICAL ARTICLE; DISEASE SEVERITY; ERYTHROPOIESIS; HEMOGLOBIN ANALYSIS; HUMAN; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; MALARIA; PATHOGENESIS; POPULATION RESEARCH; ZAMBIA;

ANALYSIS OF VARIANCE; ANEMIA; ANTIMALARIALS; CHILD, PRESCHOOL; DEFEROXAMINE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBINS; HUMANS; INFANT; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-6; MACROPHAGE ACTIVATION; MALARIA, CEREBRAL; MALE; NEOPTERIN; PYRIMETHAMINE; QUININE; RETROSPECTIVE STUDIES; SULFADOXINE;

ZAMBIA;

EID: 0031891205     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.1998.00168.x     Document Type: Article

References (25)

1. Asami M, Abe T, Owhashi M & Nawa Y (1992) Appearance of adherent cells suppressive to erythropoiesis during an early stage of Plasmodium berghei infection in mice. South east Asian Journal of Tropical Medicine and Public Health 23, 184-188.
2. Burgmann H, Looareesuwan S, Kapiotis S, Viravan C, Vanijanonta S, Hollenstein U et al. (1996) Serum levels of erythropoietin in acute Plasmodium falciparum malaria. American Journal of Tropical Medicine and Hygiene 54, 280-283.
3. Clark IA & Chaudhri G (1988) Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and crythrophagocytosis. British Journal of Haematology 70, 99-103.
4. Correa PN, Eskinazi D & Axelrad AA (1994) Circulating erythroid progenitors in Polycythemia vera are hypersensitive to insulin-like growth factor I in vitro: studies in an improved serum-free medium. Blood 83, 99-112.
5. Faquin WC, Schneider TJ & Goldberg MA (1992) Effect of inflammatory cytokines on hypoxia-mduced erythropoietin production. Blood 79, 1987-1994.
6. Johnson RA, Waddelow TA, Caro J, Oliff A & Roodman GD (1989) Chronic exposure to tumour necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 74, 130-138.
7. Koury MJ & Bondurant MC (1990) Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 248, 378-381.
8. Krantz SB (1991) Erythropoietin. Blood 77, 419-434.
9. Means RT & Krantz SB (1992) Progress in understanding the pathogenesis of anaemia of chronic disease. Blood 80, 1639-1648.
10. Means RT, Dessypris EN & Krantz SB (1992) Inhibition of human erythroid colony-forming units by interleukin-1 is mediated by gamma interferon. Cellular Physiology 150, 58-67.
11. Molyneux ME, Taylor TE, Wirima JJ & Borgstein A (1989) Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Quarterly Journal of Medicine 71, 441-459.
12. Perazella M, McPhedran P, Kliger A, Lorber M, Levy E & Bia MJ (1995) Enalapril treatment of post-transplant erythrocytosis: efficacy independent of circulating erythropoietin levels. American Journal of Kidney Disease 26, 495-500.
13. Romagagni S (1992) Induction of TH-1 and TH-2 responses: a key role for the 'natural' immune response? Immunology Today 13, 378-382.
14. Semenza GL & Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molecular and Cellular Biology 12, 5447-5454.
15. Shute GT (1988) The microscopic diagnosis of malaria. In Malaria: Principles and Practice of Malariology (eds. WH Wernsdorfer & I McGregor), Churchill Livingstone, Edinburgh, pp. 781-814.
16. Thuma PE, Weiss G, Herold M & Gordeuk VR (1996) Serum neopterin, interleukin-4, and interleukin-6 concentrations in cerebral malarial patients and the effect of iron chelation therapy. American Journal of Tropical Medicine and Hygiene 54, 164-168.
17. Thuma PE, Mabeza GF, Biemba G et al. (1998) Effect of iron chelation on mortality in Zambian Children with cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, in press.
18. Tracey KJ, Wei H, Manogue KR, fong Y, Hesse D, Nguyen HT et al. (1988) Cachectin/tumour necrosis factor induces cachexia, anaemia and inflammation. Journal of Experimental Medicine 167, 1211-1227.
19. Ulich TR, Castillo J & Yin S (1990) Tumour necrosis factor exerts dose-dependent effects on erythropoiesis and myelopoiesis in vivo. Experimental Haematology 18, 311-315.
20. Wang CQ, Udupa KB & Lipschitz DA (1995) Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. Journal of Cellular Physiology 163, 134-138.
21. Weiss G, Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G et al. (1992) Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1. Experimental Haematology 20, 605-610.
22. Weiss G, Thuma PE, Mabeza G, Werner ER, Herold M & Gordeuk VR (1997) Modulatory potential of iron chelation therapy on nitric oxide formation in cerebral malaria. Journal of Infectious Disease 175, 226-230.
23. Weiss G, Wachter H & Fuchs D (1995) Linkage of cell-mediated immunity to iron metabolism. Immunology Today 16, 495-500.
24. World Health Organization Group of Experts on Nutritional Anaemias (1972) Nutritional anaemias. WHO Technical Report Series 503, 5-29.
25. Yap GS & Stevenson MM (1989) Inhibition of in vitro erythropoiesis by soluble mediators in Plasmodium chabaudi AS malaria: lack of a major role for interleukin-1, tumour necrosis factor alpha, and gamma interferon. Infection and Immunity 62, 352-362.