New approach to the synthesis of 2',3',-dideoxyadenosine and 2',3'- dideoxyinosine

Nucleosides and Nucleotides

Volumn 17, Issue 1-3, 1998, Pages 153-159

  Antonov, K V ^a   Konstantinova, I D ^a   Miroshnikov, A I ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYADENOSINE; DIDANOSINE;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; NUCLEAR MAGNETIC RESONANCE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0031890866     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319808005166     Document Type: Article

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20. The mixture also contains starting inosine and a quantity of di-O-formil derivatives.
21. It has been observed, that an increased pressure doesn't influence the yield of ddN and in the case of the large scale preparation the high pressure is due to the technical reason.
22. The discrepancy in the melting points may be due to the different solvents used for the crystallization.