Serum and cystic fluid levels of soluble interleukin-2 receptor-alpha in patients with epithelial ovarian tumors are correlated

Tumor Biology

Volumn 19, Issue 3, 1998, Pages 160-166

  De Bruijn, H W A ^a   Ten Hoor, K A ^a   Van Der Zee, A G J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

CA 125; Cystic fluid; Epithelial ovarian tumor; Interleukin 2 receptor , soluble; Ovarian cancer

Indexed keywords

CA 125 ANTIGEN; INTERLEUKIN 2 RECEPTOR; RECEPTOR SUBTYPE;

ARTICLE; BENIGN TUMOR; CONTROLLED STUDY; CORRELATION FUNCTION; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALIGNANT NEOPLASTIC DISEASE; OVARY CARCINOMA; PRIORITY JOURNAL;

EID: 0031890405     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000030003     Document Type: Article

References (17)

1. Rubin LA, Nelson DL: The soluble interleukin-2 receptor: Biology, function, and clinical application. Ann Intern Med 1990;113:619-627.
2. Fernandez-Botran F, Chilton PM, Ma Y: Soluble cytokine receptors: Their roles in immunoregulation, disease and therapy. Adv Immunol 1996;63:269-299.
3. Whicher JT, Banks RE: Cytokines as tumour markers. Scand J Clin Lab Invest 1995;55:122-144.
4. Owens OJ, Taggert C, Wilson R, Walker JJ, McKillop JH, Kennedy JH: Interleukin-2 receptor and ovarian cancer. Br J Cancer 1993;68: 364-367.
5. Ferdeghini M, Gadducci A, Prontera C, Malagnino G, Fanucchi A, Annichiarico C, Facchini V, Bianchi R: Serum soluble interleukin-2 receptor assay in epithelial ovarian cancer. Tumor Biol 1993;14:303-309.
6. Barton DPJ, Blanchard K, Michelini-Norris B, Nicosia SV, Cavanagh D, Djeu JY: High serum and ascitic soluble interleukin-2 receptor-α levels in advanced epithelial ovarian cancer. Blood 1993;81:424-429.
7. Hurteau JA, Simon HU, Kurman C, Rubin L, Mills GB: Levels of soluble interleukin-2 receptor-α are elevated in serum and ascites from epithelial ovarian cancer patients. Am J Obstet Gynecol 1994;170:918-928.
8. Hurteau JA, Woolas RP, Jacobs IJ, Oram DC, Kurman CC, Rubin LA, Nelson DL, Berchuck A, Bast RC Jr, Mills GB: Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer. Cancer 1995;76:1615-1620.
9. Scully RE: Tumors of the ovary and maldeveloped gonads: in Atlas of Tumour Pathology, series 2, fascicle 16. Washington, Washington DC Armed Forces Institute of Pathology, 1980, p 32.
10. Taniguchi T, Miaami Y: The IL-2/ IL-2 receptor system: A current overview. Cell 1993;73:5-8.
11. Haskill S, Becker S, Fowler W, Walton L: Mononuclear-cell infiltration in ovarian cancer. I. Inflammatory-cell infiltrates from tumour and ascites material. Br J Cancer 1982;45: 728-736.
12. Lentz SS, McKean DJ, Kovach JS, Podratz KC: Phenotypic and functional characteristics of mononuclear cells in ovarian carcinoma tumors. Gynecol Oncol 1989;34:136-140.
13. Yasumura S, Lin WC, Weidmann E, Hebda P, Whiteside TL: Expression of interleukin 2 receptors on human carcinoma cell lines and tumor growth inhibition by interleukin 2. Int J Cancer 1994;59:225-234.
14. McMillan DN, Kernohan NM, Flett ME, Heys SD, Deehan DJ, Sewell HF, Walfer F, Eremin O: Interleukin 2 receptors expression and interleukin 2 localisation on human solid tumour cells in situ and in vitro: Evidence for a direct role in the regulation of tumour cell proliferation. Int J Cancer 1995;60:766-772.
15. Van der Zee AGJ, de Cuyper EMJ, Limburg P, De Bruijn HWA, Krans M, De Vries EGE: Higher interleukin-6 levels in cystic fluids from patients with malignant versus benign ovarian tumors correlate with decreased hemoglobulin levels and increased platelet numbers. Cancer 1995;75:1004-1009.
16. Meazza R, Marciano S, Sforzini S, Orengo AM, Coppolechia M, Musiani P, Ardizzoni A, Santi L, Azzarone B, Ferrini S: Analysis of IL-2 receptor expression and of the biological effects of IL-2 gene transfection in small-cell lung cancer. Br J Cancer 1996;74:788-795.
17. Maggino T, Gaducci A, D'Addario V, Pecorelli S, Lissoni A, Stella M, Romagnolo C, Federghini M, Zucca S, Trio D, Trovo S: Prospective multicentre study on CA 125 in postmenopausal pelvic masses. Gynecol Oncol 1994;54:117-123.