A general synthesis of quinoline-2,5,8(1H)-triones via acylation of 2,5- dimethoxyaniline with S-tert-butyl thioacetates by application of the Knorr cyclization

Synthesis

Volumn , Issue 2, 1998, Pages 186-194

  López Alvarado, Pilar ^a   Avendaño, Carmen ^a   Menéndez, J Carlos ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

2,5 dimethoxyanilides; Knorr cyclization; Quinoline 2,5,8(1H) triones; Regioselective alkylation; oxo thioesters

Indexed keywords

2,5 DIMETHOXYANILINE; QUINOLIN 2,5,8(1H) TRIONE; QUINOLINE DERIVATIVE; S TERT BUTYL ACETOTHIOACETATE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CYCLIZATION; DEMETHYLATION; DRUG SYNTHESIS; OXIDATION; PRECURSOR; PURIFICATION; REACTION ANALYSIS;

EID: 0031889616     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-2014     Document Type: Article

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