Effect of acidosis on tension and [Ca2+]i in rat cerebral arteries: Is there a role for membrane potential?

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 2 43-2, 1998, Pages

  Peng, Hong Li ^a   Jensen, Peter E ^a   Nilsson, Holger ^a   Aalkjær, Christian ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Hypercapnia; pH; Smooth muscle

Indexed keywords

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY TONE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN ARTERY; BRAIN BLOOD FLOW; CALCIUM CELL LEVEL; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPERCAPNIA; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ACIDOSIS; ANIMALS; BICARBONATES; CALCIUM; CARBON DIOXIDE; CEREBRAL ARTERIES; FLUORESCEINS; FLUORESCENT DYES; HYDROGEN-ION CONCENTRATION; HYPERCAPNIA; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR;

EID: 0031889179     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.2.h655     Document Type: Article

References (29)

1. Aalkjær, C., and E. J. J. Cragoe. Intracellular pH regulation in resting and contracting segments of rat mesenteric resistance vessels. J. Physiol. (Lond.) 402: 391-410, 1988.
2. i of isolated mesenteric resistance arteries from rats. Am. J. Physiol. 261 (Cell Physiol. 30): C1010-C1017, 1991.
3. Aalkjær, C., and H.-L. Peng. pH and smooth muscle. Acta Physiol. Scand. In press.
4. Aalkjær, C., and L. Poston. Effects of pH on vascular tension: which are the important mechanisms? J. Vasc. Res. 33: 347-359, 1996.
5. Austin, C., and S. Wray. The effects of extracellular pH and calcium change on force and intracellular calcium in rat vascular smooth muscle. J. Physiol. (Lond.) 488: 281-291, 1995.
6. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
7. 2 on membrane electrical properties of rat cerebral arteries. Pflügers Arch. 394: 182-185, 1982.
8. Iino, S., H. Hayashi, H. Saito, H. Tokuno, and T. Tomita. Effects of intracellular pH on calcium currents and intracellular calcium ions in the rabbit portal vein. Exp. Physiol. 79: 669-680, 1994.
9. Irikura, K., P. L. Huang, J. Ma, W. S. Lee, T. Dalkara, M. C. Fishman, and T. M. Dawson. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene. Proc. Natl. Acad. Sci. USA 92: 6823-6827, 1995.
10. i. Circ. Res. 73: 314-324, 1993.
11. i and force in rat resistance arteries. Pflügers Arch. 420: 536-543, 1992.
12. 2+-selective electrodes and fura 2 in rat mesenteric resistance arteries. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H741-H746, 1993.
13. Klockner, U., and G. Isenberg. Calcium channel current of vascular smooth muscle cells: extracellular protons modulate gating and single channel conductance. J. Gen. Physiol. 103: 665-678, 1994.
14. Lattanzio, F. A. J. The effects of pH and temperature on fluorescent calcium indicators as determined with Chelex-100 and EDTA buffer systems. Biochem. Biophys. Res. Commun. 171: 102-108, 1990.
15. Mulvany, M. J., and W. Halpern. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41: 19-26, 1977.
16. Mulvany, M. J., H. Nilsson, and J. A. Flatman. Role of membrane potential in the response of rat small mesenteric arteries to exogenous noradrenaline stimulation. J. Physiol. (Lond.) 332: 363-373, 1982.
17. Murphy, M. E., and J. E. Brayden. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J. Physiol. (Lond.) 486: 47-58, 1995.
18. Parkington, H. C., M. Tare, M. A. Tonta, and H. A. Coleman. Stretch revealed three components in the hyperpolarization of guinea-pig coronary artery in response to acetylcholine. J. Physiol. (Lond.) 465: 459-476, 1993.
19. Plane, F., and C. J. Garland. Differential effects of acetylcholine, nitric oxide and levcromakalim on smooth muscle membrane potential and tone in the rabbit basilar artery. Br. J. Pharmacol. 110: 651-656, 1993.
20. Rand, V. E., and C. J. Garland. Endothelium-dependent relaxation to acetylcholine in the rabbit basilar artery: importance of membrane hyperpolarization. Br. J. Pharmacol. 106: 143-150, 1992.
21. Siegel, G., C. Kämpe, and B. J. Ebeling. pH-dependent myogenic control in cerebral vascular smooth muscle. In: Cerebral Microcirculation and Metabolism, edited by J. Cervos-Navarro and E. Fritschka. New York: Raven, 1981, p. 213-226.
22. Siegel, G., H. Roedel, J. Nolte, H. W. Hofer, and O. Bertsche. Ionic composition and ion exchange in vascular smooth muscle. In: Physiology of Smooth Muscle, edited by E. Bülbring and M. F. Shuba. New York: Raven, 1976, p. 19-39.
23. Tare, M., H. C. Parkington, H. A. Coleman, T. O. Neild, and G. J. Dusting. Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature 346: 69-71, 1990.
24. Thomas, J. A., R. N. Buchsbaum, A. Zimniak, and E. Racker. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18: 2210-2218, 1979.
25. Tian, R., P. Vogel, N. A. Lassen, M. J. Mulvany, F. Andreasen, and C. Aalkjær. Role of extracellular and intracellular acidosis for hypercapnia-induced inhibition of tension of isolated rat cerebral arteries. Circ. Res. 76: 269-275, 1995.
26. Toda, N., Y. Hatano, and K. Mori. Mechanisms underlying response to hypercapnia and bicarbonate of isolated dog cerebral arteries. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H141-H146, 1989.
27. West, G. A., D. C. Leppla, and J. M. Simard. Effects of external pH on ionic currents in smooth muscle cells from the basilar artery of the guinea pig. Circ. Res. 71: 201-209, 1992.
28. You, J. P., Q. Wang, W. Zhang, I. Jansen Olesen, O. B. Paulson, N. A. Lassen, and L. Edvinsson. Hypercapnic vasodilatation in isolated rat basilar arteries is exerted via low pH and does not involve nitric oxide synthase stimulation or cyclic GMP production. Acta Physiol. Scand. 152: 391-397, 1994.
29. Ziegelstein, R. C., L. Cheng, P. S. Blank, H. A. Spurgeon, E. G. Lakatta, R. G. Hansford, and M. C. Capogrossi. Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1424-H1433, 1993.