Oxidative stress differentially regulates the expression of γ-glutamyl transpeptidase mRNAS in the initial segment of the rat epididymis

Journal of Andrology

Volumn 19, Issue 1, 1998, Pages 92-99

  Markey, Caroline M ^a   Rudolph, Daniel B ^a   Labus, Jacquelyn C ^a   Hinton, Barry T ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Gene expression; Glutathione; Reactive oxygen species

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME SYNTHESIS; EPIDIDYMIS; GENE EXPRESSION REGULATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPERMATOZOON MATURATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; EPIDIDYMIS; GAMMA-GLUTAMYLTRANSFERASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; GLUTATHIONE DISULFIDE; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SPERMATOZOA;

EID: 0031889110     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Agrawal YP, Vanha-Perttula T. γ-Glutamyl transpeptidase, glutathione, and L-glutamic acid in the rat epididymis during postnatal development. Biol Reprod 1988;38:996-1000.
2. Aitken RJ, Irvine DS, Wu FC. Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 1991;164:542-551.
3. Aitken RJ, Buckingham D, Harkiss D. Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa. J Reprod Fertil 1993; 97:441-450.
4. Alvarez JG, Touchstone JC, Blasco L, Storey BT. Spontaneous lipid peroxidation and production of hydrogen peroxide and Superoxide in human spermatozoa: Superoxide dismutase as major enzyme protectant against oxygen toxicity. J Androl 1987;8:338-348.
5. Alvarez JG, Storey BT. Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation. Gamete Res 1989;23:77-90.
6. Aruoma OI, Halliwell B, Gajewski E, Dozdaroglu M. Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates. J Biol Chem 1989;264:20509-20512.
7. Ball RY, Mitchinson MJ. Obstructive lesions of the genital tract in men. J Reprod Fertil 1984;70:667-673.
8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
9. Brooks DE. Metabolic activity in the epididymis and its regulation by androgens. Physiol Rev 1981;61:515-555.
10. Brown DV, Amann RP, Wagley LM. Influence of rete testis fluid on the metabolism of testosterone by cultured principal cells isolated from the proximal or distal caput of the rat epididymis. Biol Reprod 1983; 28:1257-1268.
11. Chobert MN, Lahuna O, Lebargy F, Kurauchi O, Darbouy M, Bernaudin JF, Guellaen G, Barouki R, Laperche Y. Tissue-specific expression of two γ-glutamyl transpeptidase mRNAs with alternative 5′ ends encoded by a single copy gene in the rat. J Biol Chem 1980;265:2352-2357.
12. Comporti M. Three models of free radical-induced cell injury. Chem Biol Interactions 1989;72:1-56.
13. Darbouy M, Chobert MN, Lahuna O, Okamoto T, Bonvalet JP, Farman N, Laperche Y. Tissue-specific expression of multiple γ-glutamyl transpeptidase mRNAs in rat epithelia. Am J Physiol 1991;261: C1130-C1137.
14. de Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes. J Androl 1992a;13:368-378.
15. de Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa. II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl 1992b;13:379-386.
16. DeLap LW, Tate SS, Meister A. Gamma-glutamyl transpeptidase and related enzyme activities in the reproductive system of the male rat. Life Sci 1977;20:673-680.
17. Dennis ES, Sachs MM, Gerlach WL, Finnegan EJ, Peacock WJ. Molecular analysis of the alcohol dehydrogenase 2 (Adh 2) gene of maize. Nucleic Acid Res 1985;13:727-743.
18. DeSimone DW, Norton PA, Hynes RO. Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos. Dev Biol 1992;149:357-369.
19. Forman HJ, Skelton DC. Protection of alveolar macrophages from hyperoxia by γ-glutamyl transpeptidase. Am J Physiol 1990;259:L102-L107.
20. Griffiths SA, Manson MM. Rat liver γ-glutamyl transpeptidase mRNA differs in the 5′ untranslated sequence from the corresponding kidney mRNA. Cancer Lett 1989;46:69-74.
21. Griveau JF, Dumont E, Renard P, Callegari JP, Le Lannou D. Reactive oxygen species, lipid peroxidation and enzymatic defence systems in human spermatozoa. J Reprod Fertil 1995;103:17-26.
22. Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 1986;246:501-514.
23. Halliwell B, Gutteridge JM. Biologically relevant metal ion-dependent hydroxyl radical generation: an update. FEBS Lett 1992;307:108-112.
24. Hanigan MH, Ricketts WA. Extracellular glutathione is a source of cysteine for cells that express γ-glutamyl transpeptidase. Biochemistry 1993;32:6302-6306.
25. Hinton BT, Palladino MA, Mattmueller DR, Bard D, Good K. Expression and activity of γ-glutamyl transpeptidase in the rat epididymis. Mol Reprod Dev 1991;28:40-46.
26. Hinton BT, Palladino MA, Rudolph DB, Labus JC. The epididymis as protector of maturing spermatozoa. Reprod Fertil Dev 1995;7:731-746.
27. Hyslop PA, Hindshaw DB, Halsey WA, Schraufstätter IU, Sauerheber RD, Spragg RG, Jackson JH, Cochrane CG. Mechanisms of oxidant-mediated cell injury: the glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem 1988;263:1665-1675.
28. Jones R, Mann T, Sherins R. Peroxidative breakdown of phospholipids by human spermatozoa, spermicidal properties of fatty acid peroxides and protective action of seminal plasma. Fertil Steril 1979;31:531-537.
29. Knickelbein RG, Ingbar DH, Seres T, Snow K, Johnston RB, Fayemi O, Gumkowski F, Jamieson JD, Warshaw JB. Hypoxia enhances expression of γ-glutamyl transpeptidase and increases protein S-glutathiolation in rat lung. Am Physiol Soc 1996;270:L115-L122.
30. Kugelman A, Choy HA, Liu R, Shi MM, Gozal E, Forman HJ. γ-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells. Am J Respir Cell Mol Biol 1994;11:586-592.
31. Kurauchi O, Lahuna O, Darbouy M, Aggerbeck M, Chobert MN, Laperche Y. Organization of the 5′ end of the rat γ-glutamyl transpeptidase gene: structure of a promoter active in the kidney. Biochemistry 1991;30:1618-1623.
32. Lan ZJ, Labus JC, Hinton BT. Regulation of gamma glutamyl transpeptidase (GGT) catalytic activity and protein level in the initial segment of the rat epididymis by testicular factors: role of basic fibroblast growth factor Biol Reprod 1998;58: in press.
33. Laperche Y, Bulle F, Aissani T, Chobert MN, Aggerbeck M, Hanoune J, Guellaen G. Molecular cloning and nucleotide sequence of rat kidney γ-glutamyl transpeptidase cDNA. Proc Natl Acad Sci USA 1986;83: 937-941. [Published erratum appears in Proc Natl Acad Sci USA 1989;86:3159.]
34. Lui RM, Hu H, Robison TW, Forman HJ. Increased γ-glutamylcysteine synthetase and γ-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity. Am J Respir Cell Mol Biol 1996a;14:192-197.
35. Lui RM, Hu H, Robison TW, Forman HJ. Differential enhancement of γ-glutamyl transpeptidase and γ-glutamylcysteine synthetase by tertbutylhydroquinone in rat lung epithelial L2 cells. Am J Respir Cell Mol Biol 1996b;14:186-191.
36. Markey CM, Jequier AM, Meyer GT. Effects of ischaemia on the caput epididymis and its relationship to higher epididymal obstruction: a qualitative study in the ram. Int J Androl 1995;18:185-196.
37. Markey CM, Meyer GT. A quantitative description of the epididymis and its microvasculature: an age-related study in the rat. J Anal 1992;180: 255-262.
38. Meister A. Glutathione, ascorbate, and cellular protection. Cancer Res 1994;54:1969s-1975s.
39. Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983;52:711-760.
40. Meyer M, Schreck R, Baeuerle PA. Hydrogen peroxide and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 1993;12: 2005-2015.
41. Mokrasch LC, Teschke EJ. Glutathione content of cultured cells and rodent brain regions: a specific fluorometric assay. Anal Biochem 1984; 140:506-509.
42. Nose K, Shibanuma M, Kikuchi K, Kageyama H, Sakiyama S, Kuroki T. Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Ear J Biochem 1991;201:99-106.
43. Palladino MA, Laperche Y, Hinton BT. Multiple forms of γ-glutamyl transpeptidase messenger ribonucleic acid are expressed in the adult rat testis and epididymis. Biol Reprod 1994;50:320-328.
44. Palladino MA, Hinton BT. Developmental regulation of multiple γ-glutamyl transpeptidase messenger ribonucleic acid transcripts expressed in the postnatal rat epididymis. Biochem Biophys Res Commun 1994a; 198:554-559.
45. Palladino MA, Hinton BT. Expression of multiple γ-glutamyl transpeptidase messenger ribonucleic acid transcripts in the adult rat epididymis is differentially regulated by androgens and testicular factors in a region-specific manner. Endocrinology 1994b;135:1146-1156.
46. Pawlak A, Lahuna O, Bulle F, Suzuki A, Ferry N, Siegrist S, Chikhi N, Chobert MN, Guellaen G, Laperche Y. γ-glutamyl transpeptidase: a single copy gene in the rat and a multigene family in the human genome. J Biol Chem 1988;263:9913-9916.
47. Rudolph DB, Hinton BT. Stability and transcriptional regulation of gamma-glutamyl transpeptidase mRNA expression in the initial segment of the rat epididymis. J Androl 1997;18:501-512.
48. Setchell BP, Waites GMH, Till AR. Variations in blood flow within the epididymis and testis of the sheep and rat. Nature 1964;203:317-318.
49. Sujarit S, Jones RC, Setchell BP, Chaturapanich G, Lin M, Clulow J. Stimulation of protein secretion in the initial segment of the rat epididymis by fluid from the ram rete testis. J Reprod Fertil 1990;88: 315-321.
50. Wu B, Hunt C, Morimoto R. Structure and expression of the human gene encoding major heat shock protein HSP70. Mol Cell Biol 1985;5:330-341.