Extrahepatic deposition and cytotoxicity of lithocholic acid: Studies in two hamster models of hepatic failure and in cultured human fibroblasts

Hepatology

Volumn 27, Issue 2, 1998, Pages 546-556

  Ceryak, Susan ^a   Bouscarel, Bernard ^a   Malavolti, Mauro ^b   Fromm, Hans ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLIC ACID; LACTATE DEHYDROGENASE; LITHOCHOLIC ACID; LOW DENSITY LIPOPROTEIN; OXIDOREDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; CONTROLLED STUDY; CYTOTOXICITY; ENTEROHEPATIC CIRCULATION; FIBROBLAST; HEPATOBILIARY DISEASE; HYDROXYLATION; LIPOPROTEIN METABOLISM; LIVER FAILURE; LIVER RESECTION; NONHUMAN; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; BILE DUCTS; BLOOD PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; CHOLIC ACID; CHOLIC ACIDS; CRICETINAE; ENTEROHEPATIC CIRCULATION; FIBROBLASTS; HEPATECTOMY; HUMANS; INJECTIONS, INTRAVENOUS; LIGATION; LIPOPROTEINS, LDL; LITHOCHOLIC ACID; LIVER FAILURE; MALE; SERUM ALBUMIN; TISSUE DISTRIBUTION;

EID: 0031889041     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270232     Document Type: Article

References (15)

1. Angelin B, Björkhem I, Einarsson K, Ewerth S. Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum. J Clin Invest 1982;70:724-731.
2. Setchell KDR, Lawson AM, Blackstock EJ, Murphy A. Diurnal changes in serum unconjugated bile acids in normal man. Gut 1982;23:637-642.
3. Makino I, Nakagawa S, Mashimo K. Conjugated and unconjugated serum bile acid levels in patients with hepatobiliary diseases. Gastroenterology 1969;56:1033-1039.
4. Lewis B, Panveliwalla D, Tabaqchali S, Wootton IDP. Serum-bile acids in the stagnant-loop syndrome. Lancet 1969;1:219-220.
5. Bartholomew TC, Summerfield JA, Billing BH, Lawson AM, Setchell KDR. Bile acid profiles of human serum and skin interstitial fluid and their relationship to pruritis studied by gas chromatography-mass spectrometry. Clin Sci 1982;63:65-73.
6. Poupon RE, Chrétien Y, Poupon R, Paumgartner G. Serum bile acids in primary biliary cirrhosis; effect of ursodeoxycholic acid therapy. HEPATOLOGY 1993;17:599-604.
7. +-bile acid cotransporter of rat liver. Am J Physiol 1991;261:G810-G817.
8. Shneider BL, Dawson PA, Christie DM, Hardikar W, Wong MH, Suchy FJ. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J Clin Invest 1995;95:745-754.
9. Amelsberg A, Schteingart, CD, Ton-Nu, H-T, Hofmann AF. Carrier-mediated jejunal absorption of conjugated bile acids in the guinea pig. Gastroenterology 1996;110:1098-1106
10. Cabrai DJ, Small DM, Lilly HS, Hamilton JA. Transbilayer movement of bile acids in model membranes. Biochemistry 1987;26:1801-1804.
11. Donovan JM, Jackson AA. Rapid translocation of fully ionized bile salts (BS) depends on BS concentration, hydrophobicity and membrane cholesterol content [Abstract]. Gastroenterology. 1996;110:1184A.
12. Van Dyke R, Stephens JE, Scharschmidt BE Bile acid transport in cultured rat hepatocytes. Am J Physiol 1982;243:G484-G492.
13. Aldini R, Roda A, Montagnani M, Cerrè C, Pellicciari R, Roda E. Relationship between structure and intestinal absorption of bile acids with a steroid or side chain-modification. Steroids 1996;61:590-597.
14. Bouscarel B, Ceryak S, Gettys TW, Fromm H, Noonan F. Alteration of cAMP-mediated hormonal responsiveness by bile acids in cells of nonhepatic origin. Am J Physiol 1995;268:G908-G916.
15. Rudman D, Kendall FE. Bile acid content of human serum. II. The binding of cholanic acids by human plasma proteins. J Clin Invest 1957;36:538-542.