Nitric oxide-related cyclic GMP-independent relaxing effect of N-acetylcysteine in lipopolysaccharide-treated rat aorta

British Journal of Pharmacology

Volumn 123, Issue 6, 1998, Pages 1221-1229

  Muller, Bernard ^a   Kleschyov, Andrei L ^a,b   Malblanc, Sophie ^a   Stoclet, Jean Claude ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Cyclic GMP; Dinitrosyl iron complexes; K+ channels; Lipopolysaccharide; N acetylcysteine; Nitric oxide; Rat aorta; Vascular relaxation

Indexed keywords

4 AMINOPYRIDINE; ACETYLCYSTEINE; APAMIN; CHARYBDOTOXIN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; GLIBENCLAMIDE; GUANYLATE CYCLASE; IRON COMPLEX; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORADRENALIN; POTASSIUM CHLORIDE; QUINOXALINE DERIVATIVE; TETRABUTYLAMMONIUM; THIOSULFATE;

ANIMAL TISSUE; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ACETYLCYSTEINE; ANIMALS; AORTA, THORACIC; CYCLIC GMP; IRON COMPOUNDS; LIPOPOLYSACCHARIDES; MALE; MUSCLE RELAXATION; NITRIC OXIDE; RATS; RATS, WISTAR;

EID: 0031888761     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701737     Document Type: Article

References (39)

1. + currents in frog cardiac myocytes. Br. J. Pharmacol., 121, 1369-1377.
2. ANDRIANTSITOHAINA, R., LAGAUD, G.J.L., ANDRE, A., MULLER, B. & STOCLET, J.C. (1995). Effects of cGMP on calcium handling in ATP-stimulated rat resistance arteries. Am. J. Physiol., 268, H1223-H1231.
3. ARCHER, S., HUANG, J.M.C., HAMPL, V., NELSON, P.D., SCHULTZ, P.J. & WEIR, K. (1994). Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A., 91, 7583-7587.
4. + channels in cGMP-mediated pial artery vasodilatation. Am. J. Physiol., 270, H423-H426.
5. BAUERSACHS, J., HECKER, M. & BUSSE, R. (1994). Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation. Br. J. Pharmacol., 113, 1548-1553.
6. BOLOTINA, V.M., NAJIBI, S., PALACINO, J.J., PAGANO, P.J. & COHEN, R.A. (1994). Nitric oxide directly activated calcium-dependent potassium channels in vascular smooth muscle. Nature, 368, 850-853.
7. BRUNK, C.F., JONES, K.C. & JAMES, T.W. (1979). Assay for nanogram quantities of DNA in cellular homogenates. Anal. Biochem., 92, 497-500.
8. BUTT, E., VAN BEMMELEN, M., FISCHER, L., WALTER, U. & JASTORFF, B. (1990). Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3′5′-monophosphorothioates. FEBS Lett., 263, 47-50.
9. +15 mole level. Anal. Biochem., 70, 195-202.
10. i, and arterial smooth muscle relaxation. Am. J. Physiol., 263, C468-473.
11. CORBETT, J.A., LANCASTER, J.R., SWEETLAND, M.A. & MCDANIEL, M.L. (1991). Interleukin-1β induced formation of EPR-detectable iron nitrosyl complexes in islets of Langerhans. J. Biol. Chem., 266, 21351-21354.
12. CORRIU, C., FELETOU, M., CANET, E. & VANHOUTTE, P.M. (1996). Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. Br. J. Pharmacol., 119, 959-964.
13. DRAPIER. J.C., PELLAT, C. & HENRY, Y. (1991). Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages. J. Biol. Chem., 266, 10162-10167.
14. GARTHWAITE, J., SOUTHAM, E., BOULTON, S., NIELSEN, E.B., SCHMIDT, K. & MAYER. B. (1995). Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one. Mol. Pharmacol., 48, 184-188.
15. HECKER, M., BARA, A.T., BAUERSACHS, J. & BUSSE, R. (1994). Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol., 481, 407-414.
16. KLESCHYOV, A.L., MORDVINTCEV, P.I. & VANIN, A.F. (1985). Role of nitric oxide and iron in hypotensive action of nitrosyl iron complexes with various anion ligands. Stud. Biophys., 105, 93-102.
17. KLESCHYOV, A.L., MULLER, B. & STOCLET, J.C. (1997). Nitric oxide (NO) store as dinitrosyl-iron complexes in lipopolysaccharide-treated isolated rat aorta: localization and mechanism of formation. Br. J. Pharmacol. Proc. Suppl., 120, 90P.
18. KURIYAMA, H., KITAMURA, K. & NABATA, H. (1995). Pharmacological and physiological significance of ions channels and factors that modulate them in vascular tissues. Pharmacol. Rev., 47, 387-573.
19. LANCASTER, J.R. & HIBBS, J.B. (1990). EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. U.S.A., 87, 1223-1227.
20. MARTIN, W., VILLANI, G.M., JOTHIANANDAN, D. & FURCHGOTT, R.F. (1985). Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J. Pharmacol. Exp. Ther., 232, 708-716.
21. MONCADA, S. & HIGGS, E.A. (1995). Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J., 9, 1319-1330.
22. MULLER, B., KLESCHYOV, A.L. & STOCLET, J.C. (1996). Evidence for N-acetylcysteine-sensitive nitric oxide stores as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta. Br. J. Pharmacol., 119, 1281-1285.
23. MULLER, B., KLESCHYOV, A.L. & STOCLET, J.C. (1997). Nitric oxide (NO) store as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta: cyclic GMP-independent relaxing effect of NO released by N-acetylcysteine. Br. J. Pharmacol. Proc. Suppl., 120, 91P.
24. MÜLSCH, A., MORDVINTCEV, P., VANIN, A.F. & BUSSE, R. (1991). The potent and guanylyl cyclase activating dinitrosyl-iron (II) complex is stored in a protein-bound form in vascular tissue and is released by thiols. FEBS Lett., 294, 252-256.
25. NAGAO, T. & VANHOUTTE, P.M. (1992). Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery. J. Physiol., 445, 335-367.
26. OHLMANN, P., MARTINEZ, C.M., SCHNEIDER, F., STOCLET, J.C. & ANDRIANTSITOHAINA, R. (1997). Characterization of endothelium-derived relaxing factors released by bradykinin in human resistance arteries. Br. J. Pharmacol., 121, 657-664.
27. x-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and non-heme iron proteins. Biochem. Biophys. Res. Commun., 166, 119-125.
28. ROBERTSON, B.E., SCHUBERT, R., HESCHELER, J. & NELSON, M.T. (1993). cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle. Am. J. Physiol., 265, C299-C303.
29. SCHMIDT, H.H.H.W., LOHMANN, S.M. & WALTER, U. (1993). The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochem. Biophys. Acta, 1178, 153-175.
30. SCHRAMMEL, A., BEHRENDS, S., SCHMIDT, K., KOESLING, D. & MAYER, B. (1996). Characterization of 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one as a heme site inhibitor of nitricoxide-sensitive guanylyl-cyclase. Mol. Pharmacol., 50, 1-5.
31. STADLER, J., BERGONIA, H.A., DI SILVIO, M., SWEETLAND, M.A., BILLIAR, T.R., SIMMONS, R.L. & LANCASTER, J.R. (1993). Nonheme iron-nitrosyl complex formation in rat hepatocytes: detection by electron paramagnetic resonance spectroscopy. Arch. Biochem. Biophys., 302, 4-11.
32. STAMLER, J.S. (1994). Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell, 78, 931-936.
33. STOCLET, J.C., FLEMING, I., GRAY, G.A., JULOU-SCHAEFFER, G., SCHNEIDER, F., SCHOTT, C., SCHOTT, C. & PARRATT, J.R. (1993). Nitric oxide and endotoxemia. Circulation. 87, V77-80.
34. + channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscles cells. Pflügers Arch., 423, 167-172.
35. TSUCHIDA, S., HIRAOKA, M., SUDO, M., KIGOSHI, S. & MURAMATSU, I. (1994). Attenuation of sodium nitroprusside responses after prolonged incubation of rat aorta with endotoxin. Am. J. Physiol., 267, H2305-H2310.
36. VANIN, A.F., STUKAN, R.A. & MANUKHINA, E.B. (1996). Physical properties of dinitrosyl iron complexes with thiol-containing ligands in relation with their vasodilator activity. Biochim. Biophys. Acta. 1295, 5-12.
37. VEDERNIKOV, Y.P., MORDVINTCEV, P.I., MALENKOVA, I.V. & VANIN, A.F. (1992). Similarity between the vasorelaxing activity of dinitrosyl iron cysteine complexes and endothelium-derived relaxing factor. Eur. J. Pharmacol., 211, 313-317.
38. WOLIN, M.S., CHERRY, P.D., RODENBURG, J.M., MESSINA, E.J. & KALEY, G. (1990). Methylene blue inhibits vasodilatation of skeletal muscle arterioles to acetylcholine and nitric oxide via extracellular generation of Superoxide anion. J. Pharmacol. Exp. Ther., 254, 872-876.
39. ZYGMUNT, P.M. & HÖGESTÄTT, E.D. (1996). Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br. J. Pharmacol., 117, 1600-1606.