The mechanism by which epinastine stops an adenosine analog from contracting BDE rat airways

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 2, 1998, Pages 522-530

  Meade, Christopher J ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 N [2 (4 AMINOPHENYL)ETHYL]ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; CHLORPHENIRAMINE; CYCLO(GLUTAMINYLTRYPTOPHYLPHENYLALANYLGLYCYLLEUCYLMETHIONYL); EPINASTINE; IBERIOTOXIN; NEUROKININ 2 RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

EID: 0031888348     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.2.9704097     Document Type: Article

References (35)

1. Polosa, R., K. Rajakulasingam, M. K. Church, and S. T. Holgate. 1992. Repeated inhalation of bradykinin attenuates adenosine 5′-monophosphate (AMP) induced bronchoconstriction in asthmatic airways. Eur. Respir. J. 5:700-706.
2. Phillips, G. D., V. L. Scott, R. Richards, and S. T. Holgate. 1989. Effect of nedocromil sodium and sodium cromoglycate against bronchoconstriction induced by inhaled adenosine 5′-monophosphate. Eur. Respir. J. 2:210-217.
3. Takashima, T., G. Tamura, K. Yamauchi, T. Miyamoto, and T. Shida. 1992. Clinical study of WAL 801 CL (epinastine) on adult bronchial asthma - multicenter double blind controlled study versus ketotifen fumarate. J. Clin. Ther. Med. 8(Suppl. 1):169-197.
4. Misawa, M., and Y. Kanai. 1991. Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. Arzneimittelforschung 41:1145-1149.
5. Pauwels, R. A., and M. E. van der Straeten. 1987. An animal model for adenosine-induced bronchoconstriction. Am. Rev. Respir. Dis. 136: 374-378.
6. 3 receptor: APNEA induces bronchospasm in BDE rats by a neurally mediated mechanism involving cells resembling mast cells. J. Pharmacol. Exp. Ther. 279:1148-1156.
7. Ward, J. K., A. J. Fox, P. J. Barnes, and M. G. Belvisi. 1994. Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor. Br. J. Pharmacol. 111:1095-1102.
8. Dupont, L. J., C. J. Meade, M. G. Demedts, and G. M. Verleden. 1996. Epinastine (WAL801CL) modulates non-cholinergic contraction in guinea pig airways in vitro by a prejunctional mechanism. Eur. Respir. J. 9:1433-1438.
9. 3H]-ketanserin. Eur. J. Pharmacol. 118:13-23.
10. 1D receptors can both activate and inhibit adenylate cyclase in transfected cells. Eur. J. Pharmacol. 247:177-184.
11. 1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 337:595-601.
12. 3 recognition sites by radioligand binding in NG108-15 neutroblastomaglioma cells. Eur. J. Pharmacol. 143:291-292.
13. 4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 33:543-549.
14. 7 serotonin receptor subtype. J. Biol. Chem. 268:18200-18204.
15. 1 antagonists for CNS and peripheral receptors? Eur. J. Pharmacol. 232:199-205.
16. Fügner, A., W. D. Bechtel, F. J. Kuhn, and J. Mierau. 1988. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung 10:1446-1453.
17. Meade, C. J. 1993. Epinastine can block bronchospasm induced by electrical stimulation of the vagus nerve. Eur. Respir. J. 6:316s.
18. Kamikawa, Y. 1989. Inhibitory effect of anti-allergic drugs on cholinergic and non-cholinergic neurotransmissions of guinea pig bronchial muscle in vitro. Ann. Allergy 63:59-63.
19. Aizawa, H., H. Inoue, N. Miyazaki, T. Ikeda, N. Shigematsu, and Y. Ito. 1990. Effects of azelastine on vagal neuroeffector transmission in canine and human airway smooth muscle. J. Allergy Clin. Immunol. 86: 171-176.
20. Nieber, K., C. Baumgarten, R. Rathsack, J. Furkert, E. Laake, S. Muller, and G. Kunkel. 1993. Effect of azelastine on substance P content in bronchoalveolar and nasal lavage fluids of patients with allergic asthma. Clin. Exp. Allergy 23:69-71.
21. Stretton, D., M. Miura, M. G. Belvisi, and P. J. Barnes. 1992. Calcium activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc. Natl. Acad. Sci. U.S.A. 89:1325-1329.
22. Kamei, C., M. Akagi, M. Mio, K. Kitazumi, K. Izushi, S. Masaki, and K. Tasaka. 1992. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: I. Elucidation of the mechanism for histamine release inhibition. Immunopharmacol. Immunotoxicol. 14:191-205.
23. 2 receptor in the mouse. J. Pharmacol. Exp. Ther. 268:104-109.
24. 1-like receptor. J. Appl. Physiol. 77:1135-1141.
25. Takahashi, T., J. K. Ward, S. Tadjkarimi, M. H. Yacoub, P. J. Barnes, and M. G. Belvisi. 1995. 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. Am. J. Respir. Crit. Care Med. 152:377-380.
26. Buckner, C. K., D. Dea, N. Liberati, and R. O. Krell. 1991. A pharmacologic examination of receptors mediating serotonin-induced bronchoconstriction in the anesthetized guinea pig. J. Pharmacol. Exp. Ther. 257:26-34.
27. 14C-epinastine hydrochloride (WAL 801 CL): I. Blood level, tissue distribution and urinary and fecal excretion after single and repeated administration in rats. Jpn. Pharmacol. Ther. 20:121-131.
28. Sadavongvivad, C. 1970. Pharmacological significance of biogenic amines in the lungs: 5-Hydroxytryptamine. Br. J. Pharmacol. 38:353-365.
29. Vanlommel, A., and J. M. Lauweryns. 1993. Neuroepithelial bodies in the fawn hooded rat lung - morphological and neuroanatomical evidence for a sensory innervation. J. Anal. 183:553-566.
30. Johnson, D. E., T. J. Kulik, J. E. Lock, R. P. Elde, and T. R. Thompson. 1985. Bombesin-, calcitonin-, and serotonin-immunoreactive pulmonary neuroendocrine cells in acute and chronic neonatal lung disease. Pediatr. Pulmonol. 1(Suppl.):13-20.
31. Gosney, J. R. 1993. Neuroendocrine cell-populations in postnatal human lungs - minimal variation from childhood to old-age. Anal. Rec. 236: 177-180.
32. Bousbaa, H., and J. Fleury-Feith. 1991. Effects of a long-standing challenge on pulmonary neuroendocrine cells of actively sensitized guinea pigs. Am. Rev. Respir. Dis. 144:714-717.
33. Adamus, W. S., J. Oldigs-Kerber, and H. F. Lohmann. 1987. Antihistamine activity and central effects of WAL 801 CL in man. Eur. J. Clin. Pharmacol. 33:381-385.
34. 2 antagonist ketanserin in adult atopic asthma. Eur. J. Clin. Pharmacol. 35:209-212.
35. 2 antagonist ketanserin on adenosine-induced bronchoconstriction in asthmatic subjects. Immunopharmacology 23:21-28.