Diazepam induced early oxidative changes at the subcellular level in rat brain

Molecular and Cellular Biochemistry

Volumn 178, Issue 1-2, 1998, Pages 41-46

  Musavi, Sarah ^a   Kakkar, Poonam ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Antioxidants; Diazepam; Free radicals; Rat brain

Indexed keywords

ANTIOXIDANT; DIAZEPAM; FREE RADICAL; ISOENZYME; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN MITOCHONDRION; BRAIN REGION; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; DIAZEPAM; FREE RADICALS; GLUTATHIONE REDUCTASE; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0031887883     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006834706117     Document Type: Article

References (28)

1. Verity MP: Oxidative damage and repair in the developing nervous system. Neurotoxicol 15: 81-92, 1994
2. Ravindranath V, Boyd MR: Xenobiotic metabolism in brain. Drug Metab Rev 27: 419-448, 1995
3. Clemens JA, Panetta JA Free radicals in central nervous system diseases. In: B David, PG Winyard (eds). Free Radical Species. Academic Press, London, 1995, pp 73-83
4. Klee S, Nurenberger MC, Ungemach FR: The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: Evaluation of pathobiochemical alterations. Chem-Biol Interact 93: 91-102, 1994
5. Yang C-S, Lin N-N, Tsai P-J, Liu L, Kuo J-S: In vivo evidence of hydroxyl radical formation induced by elevation of extracellular glutamate after cerebral ischemia in the cortex of anesthetized rats. Free Rad Biol Med 20: 245-250, 1996
6. Viswanathan V, Kakkar P, Seth PK: Early ultrastructural changes in rat brain after single exposure to diethylether. J Environ Biol 16: 89-92, 1995
7. Awasthi S, Kakkar P, Viswanathan PN, Bhardwaj R: Effect of anaesthetic ether on lipid peroxidation and superoxide dismutase isozymes of young and adult rat brain. Ind J Exp Biol 27: 674-649, 1989
8. Awasthi S, Kakkar P, Viswanathan PN, Bhardwaj R: Effect of phenobarbitone on antioxidant mechanisms in the brain. Clin Chem Enz Commun 1: 145-152, 1989
9. Awasthi S, Kakkar P, Viswanathan PN, Bhardwaj R: Increase in lysolecithin content of brain microsomes in phenobarbitone-administered rats and its relation to lipid peroxidation. J Neurochem 57: 277-281, 1991
10. Glowinski J, Iverson LL: Regional studies of catecholamine in cat brain. J Neurochem 13: 655-669, 1966
11. Mustafa MG: Augmentation of mitochondrial oxidation in lung tissue during recovery of animal from acute ozone exposure. Arch Biochem Biophys 165: 531-538, 1974
12. Ohkawa H, Ohishi N, Yagi K: Assay of lipid peroxidation in animal tissue by thiobarbituric acid reaction. Anal Biochem 95: 351-358, 1979
13. Nishikimi M, Rao NA, Yagi K: The occurrence of superoxide anion in the reaction of reduced PMS and molecular oxygen. Biochem Biophys Res Commun 46: 849-854, 1972
14. Kakkar P, Das B, Viswanathan PN: Modified spectrophotometric assay of SOD. Ind J Biochem Biophys 2: 130-132, 1984
15. Carlberg I, Mannervik B: Glutathione reductase. In: A Meister (eds). Methods in Enzymology Vol. 113, Academic Press, New York, 1985, pp 484-490
16. Sedlak Y, Lindsay RH: Estimation of total, protein bound and non-protein bound -SH group in tissue with Ellmanoic reagent. Anal Biochem 25: 192-205, 1968
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951
18. Fisher RA: Statistical Methods for Research Work. 11th edn. Oliver and Boyd, Edinburgh, 1950
19. Mehrotra S, Kakkar P, Viswanathan PN: Mitochondrial damage by active oxygen species in vitro. Free Rad Biol Med 10: 277-285, 1991
20. Mehrotra S, Kakkar P, Viswanathan PN: Influence of some biological response modifiers on active oxygen and calcium mediated in vitro swelling of rat liver mitochondria. Mol Cell Biochem 124: 101-106, 1993
21. Kakkar P, Mehrotra S, Viswanathan PN: Interrelation of active oxygen species, membrane damage and altered calcium functions. Mol Cell Biochem 111: 11-15, 1992
22. Kakkar P, Viswanathan V, Viswanathan PN: Oxidative stress mediated calcium deregulation as a common unspecific mechanism in toxicity. Toxicol Ecotoxicol News 2: 106-112, 1995
23. Kakkar P, Mehrotra S, Viswanathan PN: t-BHP induced in vitro swelling of rat liver mitochondria. Mol Cell Biochem 154: 39-45, 1996
24. 2+: Effect of coenzyme Q redox state. Free Rad Biol Med 18: 55-59, 1995
25. Wyatt I, Gyte A, Mainwaring G, Widdowson PS, Lock EA: Glutathione depletion in the liver and brain produced by 2-chloropropionic acid: relevance to cerebellar granule cell necrosis. Arch Toxicol 70: 380-389, 1996
26. Winkler BS, Orselli SM, Rex TS: The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective. Free Radic Biol Med 17: 333-349, 1994
27. Mennini R, Caccia S, Garattini S: Mechanism of action of anxiolytic drags. Prog Drug Res 31: 315-347, 1987
28. Krueger KE, Papadopoulos V: Mitochondrial benzodiazepine receptors and the regulation of steroid biosynthesis. Annu Rev Pharmacol Toxicol 32: 211-237, 1992