Transient triglyceridemia in healthy normolipidemic men increases cellular processing of large very low density lipoproteins by fibroblasts in vitro

Journal of Lipid Research

Volumn 39, Issue 2, 1998, Pages 423-436

  Björkegren, Johan ^a   Karpe, Fredrik ^a   Vitols, Sigurd ^a   Tornvall, Per ^a   Hamsten, Anders ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

3 hydroxy 3 methylglutaryl coezyme A activity; ApoB 100; ApoC; ApoE; Intralipid; LDL receptor binding

Indexed keywords

VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BINDING SITE; CELL INTERACTION; ENZYME ACTIVITY; FIBROBLAST; GLYCOSYLATION; HUMAN; HUMAN EXPERIMENT; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; LIPID BLOOD LEVEL; LIPOLYSIS; LIPOPROTEIN METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN CONTENT;

ADULT; CELLS, CULTURED; CHYLOMICRONS; FASTING; FAT EMULSIONS, INTRAVENOUS; FIBROBLASTS; FOOD; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; RECEPTORS, LDL; TRIGLYCERIDES;

EID: 0031887831     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Gotto, A. M., Jr., H. J. Pownall, and R. J. Havel. 1986. Introduction to the plasma lipoproteins. Methods Enzymol. 128: 3-41.
2. Havel, R. J., J. P. Kane, and M. L. Kashyap. 1973. Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. J. Clin. Invest. 52: 32-38.
3. Tomoci, L., C. A. Scheraldi, X. Li, H. Ide, I. J. Goldberg, and N. A. Le. 1993. Abnormal activation of lipoprotein lipase by non-equilibrating apoC-II, further evidence for the presence of non-equilibrating pools of apoC-II and apoC-III in plasma lipoproteins. J. Lipid Res. 34: 1793-1803.
4. LaRosa, J. C., R. I. Levy, P. Herbert, S. E. Lux, and D. S. Fredrickson. 1970. A specific apoprotein activator for lipoprotein lipase. Biochem. Biophys. Res. Commun. 41: 57-62.
5. Brown, M. V., and M. L. Baginsky. 1972. Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein. Biochem. Biophys. Res. Commun. 46: 375-382.
6. Wang, C-S., W. J. McConathy, H. U. Kloer, and P. Alaupovic. 1985. Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J. Clin. Invest. 75: 384-390.
7. Shelburne, F., J. Hanks, W. Meyers, and S. Quarfordt. 1980. Effects of apoproteins on hepatic uptake of triglyceride emulsions in the rat. J. Clin. Invest. 65: 652-658.
8. Windler, E., Y. Chao, and R. J. Havel. 1980. Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins. J. Biol. Chem. 255: 8303-8307.
9. Windler, E., and R. J. Havel. 1985. Inhibitory effect of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26: 556-565.
10. Aalto-Setälä K., E. A. Fisher, X. Chen, T. Chajek-Shaul, T. Hayek, R. Zechner, A. Walsh, R. Ramakrishnan, H. N. Ginsberg, and J. L. Breslow. 1992. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) C-III transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apoC-III and reduced apoE on the particles. J. Clin. Invest. 90: 1889-1900.
11. deSilva, H. V., S. J. Lauer, J. Wang, W. S. Simonet, K. H. Weisgraber, R. W. Mahley, and J. M. Taylor. 1994. Overexpression of human apolipoprotein C-III in transgenic mice results in a accumulation of apolipoprotein B-48 remnants that is corrected by excess apolipoprotein E. J. Biol. Chem. 269: 2324-2335.
12. Ginsberg, H. N., N-A. Le, I. J. Goldberg, J. C. Gibson, A. Rubinstein, P. Wang-Iverson, R. Norum, and W. V. Brown. 1986. Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins C-III and A-I. J. Clin. Invest. 78: 1287-1295.
13. von Eckardstein, A., H. Holz, M. Sandkamp, W. Weng, H. Funke, and G. Assmann. 1991. Apolipoprotein C-III (Lys-Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. J. Clin. Invest. 87: 1724-1731.
14. Weisgraber, K. H., R. W. Mahley, R. C. Kowal, J. Herz, J. L. Goldstein, and M. S. Brown. 1990. Apolipoprotein C-I modulates the interaction of apolipoprotein E with β-migrating very low density lipoproteins (β-VLDL) and inhibits binding of β-VLDL to low density lipoprotein receptor-related protein. J. Biol. Chem. 265: 22453-22459.
15. Sehayek, E., and S. Eisenberg. 1991. Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266: 18259-18267.
16. Shachter, N. S., T. Ebara, R. Ramakrishnan, G. Steiner, J. L. Breslow, H. N. Ginsberg, and J. D. Smith. 1996. Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein C-I. J. Clin. Invest. 98: 846-855.
17. Packard, C. J., A. Munro, A. R. Lorimer, A. M. Gotto, Jr., and J. Shepherd. 1984. Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects. J. Clin. Invest. 74: 2178-2192.
18. Gianturco, S. H., F. B. Brown, A. M. Gotto, Jr., and W. A. Bradley. 1982. Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts. J. Lipid Res. 23: 984-993.
19. Bradley, W. A., S-L. H. Hwang, J. B. Karlin, A. H. Y. Lin, S. C. Prasad, A. M. Gotto, Jr., and S. H. Gianturco. 1984. Low-density lipoprotein binding determinants switch from apolipoprotein E to apolipoprotein B during conversion of hypertriglyceridemic very low density lipoprotein to low density lipoproteins. J. Biol. Chem. 259: 14728-14735.
20. Friedman, G., D. Gavish, T. Vogel, and S. Eisenberg. 1990. Cellular metabolism of human plasma intermediate density lipoprotein. Biochim. Biophys. Acta. 1044: 118-126.
21. Gianturco, S. H., A. M. Gotto, Jr., R. L. Jackson, J. R. Patsch, H. D. Sybers, O. D. Taunton, D. L. Yeshurun, and L. C. Smith. 1978. Control of 3-hydroxy-3-methyl-glutaryl CoA reductase activity in cultured human fibroblasts by very low density lipoproteins of subjects with hypertriglyceridemia. J Clin. Invest. 61: 320-328.
22. Gianturco, S. H., C. J. Packard, J. Shepherd, L. C. Smith, A. L. Catapano, H. D. Sybers, and A. M. Gotto, Jr. 1980. Abnormal supppression of 3-hydroxy-3-methyl-glutaryl-CoA reductase activity in cultured human fibroblasts by hypertriglyceridemic very low density lipoprotein subclasses. Lipids. 15: 456-463.
23. Chappell, D. A., G. L. Fry, M. A. Waknitz, L. E. Muhonen, and M. W. Pladet. 1993. Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipoproteins in vitro. J. Biol. Chem. 268: 25487-25493.
24. Cohn, J. S., J. R. M. Namara, S. D. Conn, J. M. Ordovas, and E. J. Schaefer. 1988. Plasma apolipoprotein changes in the triglyceride-rich lipoprotein fraction of human subjects fed a fat-rich meal. J. Lipid Res. 29: 925-936.
25. Karpe, F., G. Steiner, T. Olivercrona, L. A. Carlson, and A. Hamsten. 1993. Metabolism of triglyceride-rich lipoproteins during alimentary lipemia. J. Clin. Invest. 91: 748-759.
26. Schneeman, B. O., L. Kotite, K. M. Todd, and R. J. Havel. 1993. Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proc. Natl. Acad. Sci. USA. 90: 2069-2073.
27. Cohn, J. S., E. J. Johnson, J. S. Millar, S. D. Cohn, R. W. Milne, Y. L. Marcel, R. M. Russell, and E. J. Schaefer. 1993. Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J. Lipid Res. 34: 2033-2040.
28. Karpe, F., and M. Hultin. 1995. Endogenous triglyceride-rich lipoproteins accumulate in rat plasma when competing with a chylomicron-like triglyceride emulsion for a common lipolytic pathway. J. Lipid Res. 36: 1557-1556.
29. Björkegren, J., C. J. Packard, A. Hamsten, D. Bedford, M. Caslake, J. Shepherd, L. Foster, P. Stewart, and F. Karpe. 1996. Accumulation of large very low density lipoprotein in plasma during intravenous infusion of a chylomicron-like triglyceride emulsion reflects competition for a common lipolytic pathway. J. Lipid Res. 37: 76-86.
30. Brunzell, J. D., W. R. Hazzard, D. J. Porte, and E. L. Bierman. 1973. Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low lipoproteins in man. J. Clin. Invest. 52: 1578-1585.
31. Björkegren, J., A. Hamsten, R. W. Milne, and F. Karpe. 1997. Alterations of VLDL composition during alimentary lipemia. J. Lipid Res. 38: 301-314.
32. Hamsten, A., P. Eriksson, F. Karpe, and A. Silveira. 1994. Relationships of thrombosis and fibrinolysis to atherosclerosis. Curr. Opin. Lipidol. 5: 382-389.
33. Tornvall, P., P. Båvenholm, C. Landou, U. deFaire, and A. Hamsten. 1993. Relation of plasma levels and composition of apolipoprotein B-containing lipoproteins to angiographically defined coronary artery disease in young patients with myocardial infarction. Circulation. 88: 2180-2189.
34. Phillips, N. R., D. Waters, and R. J. Havel. 1993. Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events. Circulation. 88: 2762-2770.
35. Hixson, J. E., A. McMahan, H. C. J. McGill, and J. P. Strong, 1992. Apolipoprotein B insertion/deletion polymorphism is associated with atherosclerosis in young black but not young white males. Arterioscler. Thromb. 12: 1023-1029.
36. Carlson, K. 1973. Lipoprotein fractionation. J. Clin. Pathol. 26: 32-37.
37. McConathy, W. J., E. Koren, H. Wieland, E. M. Campos, D. M. Lee, H. U. Kloer, and P. Alaupovic. 1985. Evaluation of immunoaffinity chromotography for isolating human lipoproteins containing apolipoprotein B. J. Chromatogr. 342: 47-66.
38. Karpe, F., and A. Hamsten. 1994. Determination of apolipoproteins B-48 and B-100 in triglyceride-rich lipoproteins by analytical SDS-PAGE. J. Lipid Res. 35: 1311-1317.
39. Brown, M. S., S. E. Dana, and J. L. Goldstein. 1973. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proc. Nat. Acad. Sci. USA. 70: 2162-2166.
40. Gene, C. N., L. C. Pendelton, and A. S. Pendelton. 1987. Loss of NADPH during assays of HMG-CoA reductase: implication and approaches to minimize errors. Lipids. 22: 409-412.
41. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
42. Rumsey, S. C., N. F. Galeano, Y. Arad, and R. J. Deckelbaum, 1992. Cryopreservation with sucrose maintains normal physical and biological properties of human plasma low density lipoproteins. J. Lipid Res. 33: 1551-1561.
43. Bilheimer, D. W., S. Eisenberg, and R. J. Levy. 1972. The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations. Biochim. Biophys. Acta. 62: 212-221.
44. Goldstein, J. L., and M. S. Brown. 1974. Binding and degradation of low density lipoprotein by cultured fibroblasts: comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J. Biol. Chem. 249: 5153-5162.
45. Eriksson, M., L. Berglund, M. Rudling, P. Hemiksson, and B. Angelin. 1989. Effects of oestrogen on low density lipoprotein metabolism in males: short-term and long-term studies during hormonal treatment of prostatic carcinoma. J. Clin. Invest. 84: 802-810.
46. Zlatkis, A., B. Zak, and A. Boyle. 1953. A new method for direct determination of serum cholesterol. J. Lab. Clin. Med. 41: 486-492.
47. Kane, J. P. 1973. A rapid electrophoretic technique for identification of subunit species of apoproteins in serum lipoproteins. Anal. Biochem. 53: 350-364.
48. Bradley, W. A., and S. H. Gianturco. 1986. ApoE is necessary and sufficient for the binding of large very low density lipoproteins to the LDL receptor; apoB is unnecessary. J. Lipid Res. 27: 40-48.
49. Yamada, N., D. M. Shames, J. B. Stoudemire, and R. J. Havel. 1986. Metabolism of lipoprotein B-100 in blood plasma of rabbits: heterogeneity related to the presence of apolipoprotein E. Proc. Natl. Acad. Sci. USA. 83: 3479-3483.
50. Yamada, N., D. M. Shames, K. Takahashi, and R. J. Havel. 1988. Metabolism of apolipoprotein B-100 in large very low density lipoproteins of blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits. J. Clin. Invest. 82: 2106-2113.
51. Agnani, G., J. M. Bard, L. Candelier, S. Delattre, J. C. Fruchart, and V. Clavey. 1991. Interaction of LpB, LpB:E, LpB:C-III and LpB:C-III:E lipoproteins with the low density lipoprotein receptor of HeLa cells. Arterioscler. Thromb. 11: 1021-1029.
52. Sehayek, E., and S. Eisenberg. 1990. Abnormal composition of hypertriglyceridemic very low density lipoprotein determines abnormal metabolism. Arteriosclerosis. 10: 1088-1096.
53. Shachter, N. S., T. Hayek, T. Leff, J. D. Smith, D. W. Rosenberg, A. Walsh, R. Kamakrishnan, I. J. Goldberg, H. N. Ginsberg, and J. L. Breslow, 1994. Overexpression of apolipoprotein C-II causes hypertriglyceridemia in transgenic mice. J. Clin. Invest. 93: 1683-1690.
54. Ji, Z. S., S. Fazio, Y. L. Lee, and R. W. Mahley. 1994. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heperan sulfate proteoglycans. J. Biol. Chem. 269: 2764-2772.
55. Rapp, J. H., A. Lespine, R. L. Hamilton, N. Colyvas, A. H. Chaumeton, J. Tweedie-Hardman, L. Kotite, S. T. Kunitake, R. J. Havel, and J. P. Kane. 1994. Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorbtion from human atherosclerotic plaque. Arterioscler. Thromb. 14: 1767-1774.
56. Stiko-Rahm, A., B. Wiman, A. Hamsten, and J. Nilsson. 1990. Secretion of plasminogen activator inhibitor-1 from cultured endothelial cells is induced by very low density lipoprotein. Arteriosclerosis. 10: 1067-1073.
57. Patsch, J. R., G. Miesenböck, T. Hopferwieser, V. Mühlberger, E. Knapp, J. K. Dunn, A. M. Gotto, and W. Patsch. 1992. Relation of triglyceride metabolism and coronary artery disease. Arterioscler. Thromb. 12: 1336-1345.