Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC)

Clinical and Experimental Immunology

Volumn 111, Issue 2, 1998, Pages 402-407

  Sobajima, J ^a   Ozaki, S ^a   Uesugi, H ^a   Osakada, F ^b   Shirakawa, H ^c   Yoshida, M ^c   Nakao, K ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANEKA CORPORATION   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Anti neutrophil cytoplasmic antibodies; HMG1; HMG2; Ulcerative colitis

Indexed keywords

CATHEPSIN G; HIGH MOBILITY GROUP PROTEIN; LACTOFERRIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEIN ANTIBODY;

ADULT; AGED; ANTIBODY TITER; ARTICLE; CHILD; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PRIORITY JOURNAL; PROTEIN DETERMINATION; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIBODIES; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BLOTTING, WESTERN; CATHEPSINS; CHILD; COLITIS, ULCERATIVE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH MOBILITY GROUP PROTEINS; HUMANS; LACTOFERRIN; MALE; MIDDLE AGED; SERINE ENDOPEPTIDASES; SWINE;

EID: 0031887801     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00491.x     Document Type: Article

References (33)

1. Lüdemann J, Utecht B, Gross WL. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. J Exp Med 1990; 171:357-62.
2. Cohen Tervaert JW, van der Woude FJ, Fauci AS et al. Association between active Wegener's granulomatosis and anticytoplasmic antibodies. Arch Intern Med 1989; 149:2461-5.
3. Nolle B, Specks U, Lüdemann J et al. Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener's granulomatosis. Ann Intern Med 1989; 111:28-40.
4. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318:1651-7.
5. Saxon A, Shanahan F, Landers C et al. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990; 86:202-10.
6. Duerr RH, Targan SR, Landers C et al. Anti-neutrophil cytoplasmic antibodies in ulcerative colitis: comparison with other colitides/ diarrheal illnesses. Gastroenterol 1991; 100:1590-6.
7. Seibold F, Weber P, Klein R et al. Clinical significance of antibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis. Gut 1992; 33:657-62.
8. Cambridge G, Rampton DS, Stevens TRJ et al. Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992; 33:668-74.
9. Falk RJ, Sartor RB, Jones DA et al. Anti-neutrophil cytoplasmic autoantibodies (ANCA) in ulcerative colitis (UC). Clin Res 1990; 38:387 (Abstr.).
10. Klein R, Eisenburg J, Weber P et al. Significance and specificity of antibodies to neutrophils detected by Western blotting for the serological diagnosis of primary sclerosing cholangitis. Hepatol 1991; 14:1147-52.
11. Targan SR, Landers C, Vidrich A et al. High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis. Gastroenterol 1995; 108:1159-66.
12. Koderisch J, Andrassy K, Rasmussen M et al. "False-positive" antineutrophil cytoplasmic antibodies in HIV infection. Lancet 1990; 335:1227-8.
13. Klaassen RJL, Goldschmeding R, Dolman KM et al. Anti-neutrophil cytoplasmic autoantibodies in patients with symptomatic HIV infection. Clin Exp Immunol 1992; 87:24-30.
14. Wagner J, Andrassy K, Ritz E. Is vasculitis in subacute bacterial endocarditis associated with ANCA? Lancet 1991; 337:799-800.
15. Halbwachs-Mecarelli L, Nusbaum P, Noël LH et al. Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis. Crohn's disease and primary sclerosing cholangitis. Clin Exp Immunol 1992; 90:79-84.
16. Peen E, Almer S, Bodemar G et al. Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. Gut 1993; 34:56-62.
17. Sobajima J, Ozaki S, Osakada F et al. Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2. Clin Exp Immunol 1997; 107:135-40.
18. Majumdar A, Brown D, Kerby S et al. Sequence of human HMG2 cDNA. Nue Acids Res 1991; 19:6643.
19. Wen L, Huang JK, Johnson BH et al. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. Nue Acids Res 1989; 17:1197-214.
20. Shirakawa H, Yoshida M. Structure of a gene coding for human HMG2 protein. J Biol Chem 1992; 267:6641-5.
21. Shirakawa H, Tsuda K, Yoshida M. Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence. Biochem 1990; 29:4419-23.
22. Bustin M, Lehn DA, Landsman D. Structural features of the HMG chromosomal proteins and their genes. Biochim Biophys Acta 1990; 1049:231-43.
23. Sobajima J, Ozaki S, Okazaki T et al. Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type. Clin Exp Immunol 1996; 105:120-5.
24. Yoshida M, Shimura K. Unwinding of DNA by nonhistone chromosomal protein HMG (1+2) from pig thymus as determined with endonuclease. J Biochem 1984; 95:117-24.
25. Wiik A. Delineation of a standard procedure for indirect immunofluorescence detection of ANCA. Acta Pathol Microbiol Immunol Scand 1989; 97:12-13.
26. Charles LA, Falk RJ, Jennette JC. Reactivity of anti-neutrophil cytoplasmic autoantibodies with HL-60 cells. Clin Immunol Immunopathol 1989; 53:243-53.
27. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
28. Zhao MH, Jones SJ, Lockwood CM. Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol 1995; 99:49-56.
29. Stoffel MP, Csernok E, Herzberg C et al. Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 1996; 104:54-59.
30. Aizawa S, Nishino H, Saito K et al. Stimulation of transcription in cultured cells by high mobility group protein 1: essential role of the acidic carboxyl-terminal region. Biochem 1994; 33:14690-5.
31. Ogawa Y, Aizawa S, Shirakawa H et al. Stimulation of transcription accompanying relaxation of chromatin structure in cells overexpressing high mobility group 1 protein. J Biol Chem 1995; 270:9272-80.
32. Merenmies J, Pihlaskari R, Laitinen J et al. 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth: amino acid sequence and localization in the filopodia of the advancing plasma membrane. J Biol Chem 1991; 266:16722-9.
33. Parkkinen J, Raulo E, Merenmies J et al. Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides: enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J Biol Chem 1993; 268: 19726-38.