The transcriptional regulator Hap1p (Cyp1p) is essential for anaerobic or heme-deficient growth of Saccharomyces cerevisiae: Genetic and molecular characterization of an extragenic suppressor that encodes a WD repeat protein

Genetics

Volumn 148, Issue 2, 1998, Pages 559-569

  Chantrel, Yann ^a   Gaisne, Mauricette ^a   Lions, Claire ^a   Verdière, Jacqueline ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HEME; REGULATOR PROTEIN; REGULATOR PROTEIN HAP 1P; RNA; UNCLASSIFIED DRUG;

ARTICLE; FUNGUS GROWTH; GENE LOCATION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; SUPPRESSOR GENE; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; CARBON-OXYGEN LYASES; CLONING, MOLECULAR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FUNGAL PROTEINS; GENES, FUNGAL; HEME; IMMUNOHISTOCHEMISTRY; INTRONS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OPEN READING FRAMES; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; RIBOSOMES; RNA, SMALL NUCLEAR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC;

EUKARYOTA; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0031887447     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. AMILLET, J. M., N. BUISSON and R. LABBE-BOIS, 1995 Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae. Curr. Genet. 28: 503-511.
2. ANDREASEN, A., and T. STIER, 1953 Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in defined medium. J. Cell. Comp. Physiol. 41: 23-36.
3. ANDREASEN, A., and T. STIER, 1954 Anaerobic nutrition of Saccharomyces cerevisiae, II. Unsaturated fatty acid requirement for growth in defined medium. J. Cell. Comp. Physiol. 43: 271-281.
4. BERKOWER, C., D. LOAYZA and S. MICHAELIS, 1994 Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae. Mol. Biol. Cell 5: 1185-1198.
5. BONNEAUD, N., O OZIER-KALOGEROPOULOS, G. LI, M. LABOUESSE, L. MINVIELLE-SEBASTIA et al., 1991 A family of low and high copy replicative, integrative and single-strand S. cerevisiae/E. coli shuttle vectors. Yeast 7: 609-615.
6. CAFARELLI, E., A. FATICA, S. PRIESLEI, E. DE GREGORIO, P. FRAGAPANE. et al., 1996 Processing of the intron-encoded U16 and U18 sno RNAs: the conserved C and D boxes control both the processing reaction and the stability of the mature sno RNA. EMBO J. 15: 1121-1131.
7. CHEN, C. C., B. C. YANG and T. T. KUO, 1992 One-step transformation of yeast in stationary phase. Curr. Genet. 21: 83-84.
8. CLAISSE, M. L., G. PERE-AUBERT, L. CLAVILIER and P. P. SLONIMSKI, 1970 Méthode d'estimation de la concentration des cytochromes dans les cellules entières de levure. Eur. J. Biochem. 16: 430-438.
9. CREUSOT, F., J. VERDIÈRE, M. GAISNE and P. P. SLONIMSKI, 1988 CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast I. Overall organization of the protein sequence displays several novel structural domains. J. Mol. Biol. 204: 263-276.
10. DECKERT, J., R. PERINI, B. BALASUBRAMANIAN and R. S. ZITOMER, 1995 Multiple elements and auto-repression regulate Rox1, a repressor of hypoxic genes in Saccharomyces cerevisiae. Genetics 139:1149-1158.
11. DEFRANOUX, N., M. GAISNE and J. VERDIÈRE, 1994 Functional analysis of the zinc cluster domain of the Cyp1 (Hap1) complex regulator in heme-sufficient and heme-deficient yeast cells. Mol. Gen. Genet. 242: 699-707.
12. FYTLOVICH, S., M. GERVAIS, C. AGRIMONTI and B. GUIARD, 1993 Evidence for an interaction between the CYP1 (HAP1) activator and a cellular factor during heme-dependent transcriptional regulation in the yeast Saccharomyces cerevisiae. EMBO J. 12: 1209-1218.
13. HAWTHORNE, D., 1969 The selection of nonsense suppressors in yeast. Mutat. Res. 7: 187-197.
14. HELSER, T. L., R. A. BAAN and A. E. DAHLBERG, 1981 Characterization of a 40S ribosomal subunit complex in polyribosomes of Saccharomyces cerevisiae treated with cycloheximide. Mol. Cell. Biol. 1: 51-57.
15. HIGGINS, D. H., and P. M. SHARP, 1988 Clustal: a package for performing multiple sequence alignment on a microcomputer. Gene 73: 237-244.
16. IMAI, Y., Y. SUZUKI, M. TOHYAMA, A. WANAKA and T. TAKAYI, 1994 Cloning and expression of a neural differentiation-associated gene, p205, in the embryonal carcinoma cell line P19 and in the developing mouse. Brain Res. Mol. Brain Res. 24: 313-319.
17. ISHIDA, S., Y. TAKAHASHI and N. TOSHIYUKI, 1993 Isolation of cDNA of an auxin-regulated gene encoding a G protein β subunit-like protein from tobacco BY-2 cells. Proc. Natl. Acad. Sci. USA 90: 11152-11156.
18. KENG, T., 1992 HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 12: 2616-2623.
19. KIM, K. S., and L. GUARENTE, 1989 Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAP1. Nature 342: 200-203.
20. KISS-LASZLO, Z., Y. HENRY, J. P. BACHELLERIE, M. CAIZERGUES-FERRER and T. KISS, 1996 Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85: 1077-1088.
21. KUO, W. N., D. L. JONES, T. W. KU, K. D. WEEKS, P. M. PHALA et al., 1995 Immunoreactivity of PKC and RACK1 in baker's yeast, lobster and wheat germ. Biochem. Mol. Biol. Int. 36: 957-963.
22. KRÜGER, D., J. KOCH and I. B. BARTHELMESS, 1990 cpc-2, a new locus involved in general control of amino acid synthetic enzymes in Neurospora crassa, Curr. Genet. 18: 211-215.
23. LABBE-BOIS, R., and P. LABBE, 1990 Tetrapyrrole and heme biosynthesis in the yeast Saccharomyces cerevisiae, pp. 235-285 in Biosynthesis of Heme and Chlorophylls, edited by H. A. DAILEY. McGraw-Hill, New York.
24. MAXWELL, E. S., and M. J. FOURNIER, 1995 The small nucleolar RNAs. Annu. Rev. Biochem. 64: 897-934.
25. MOUGNEAU, E., F. ALTARE, A. E. WAKIL, S. ZHENG, T. COPPOLA et al., 1995 Expression cloning of a protective Leishmania antigen. Science 268: 563-566.
26. MÜLLER, F., D. KRÜGER, E. SATTLEGGER, B. HOFFMANN, P. BALLARIO et al., 1995 The cpc2 gene of Neurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility. Mol. Gen. Genet. 248: 162-173.
27. NASMYTH, K. A., and S. REED, 1980 Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene. Proc. Natl. Acad. Sci. USA 77: 2119-2123.
28. NEER, E., C. J. SCHMIDT, R. NAMBUDRIPAD and T. F. SMITH, 1994 The ancient regulatory-protein family of WD-repeat proteins. Nature 371: 297-300.
29. ORR-WEAVER, T. L., J. W. SZOSTAK and R. J. ROTHSTEIN, 1983 Genetic application of yeast transformation with linear and gapped plasmids. Methods Enzymol. 101: 228-245.
30. PETITJEAN, A., N. BONNEAUD and F. LACROUTE, 1995 The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins. Mol. Cell. Biol. 15: 5071-5081.
31. PFEIFER, K., T. PREZANT and L. GUARENTE, 1987 Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell 49: 19-27.
32. QU, L. H., Y. HENRY, M. NICOLOSO, B. MICHOT, M. C. AZUM et al., 1995 U24, a novel intron-encoded small nucleolar RNA with two 12nt long, phylogenetically conserved complementarities to 28S rRNA. Nucleic Acids Res. 23: 2669-2676.
33. RON, D., C. H. CHEN, J. CALDWELL, L. JAMIESON, E. ORR et al., 1994 Cloning of an intracellular receptor for protein kinase C: a homolog of the β subunit of G proteins. Proc. Natl. Acad. Sci. USA 91: 839-843.
34. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
35. SANGER, F., S. NICKLEN and A. R. COULSON, 1977 DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. USA 74: 5463-5467.
36. SHERMAN, F., G. FINK and J. B. HICKS, 1986 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
37. SIKORSKI, R. S., and P. HIETER, 1989 A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
38. THOMAS, B. J., and R. ROTHSTEIN, 1989 Elevated recombination rates in transcriptionally active DNA. Cell 56: 619-639.
39. TURI, T. G., and J. C. LOPER, 1992 Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14α-demethylase (ERG11). J. Biol. Chem. 267: 2046-2056.
40. USHINSKY, S. C., and T. KENG, 1994 A novel allele of HAP1 causes uninducible expression of HEM13 in saccharomyces cerevisiae. Genetics 136: 819-831.
41. VERDIÈRE, J., F. CREUSOT, L. GUARENTE and P. P. SLONIMSKI, 1986 The overproducing CYP1 and underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes c. Curr. Genet. 10: 339-342.
42. VERDIÈRE, J., M. GAISNE, B. GUIARD, N. DEFRANOUX and P. P. SLONIMSKI, 1988 CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast. II. Missense mutation suggests alternative Zn fingers as discriminating agents of gene control. J. Mol. Biol. 204: 277-282.
43. VERDIÈRE, J., M. GAISNE and R. LABBE-BOIS, 1991 CYP1 (HAP1) is a determinant effector of alternative expression of heme-dependent transcription in yeast. Mol. Gen. Genet. 228: 300-306.
44. ZHANG, L., and L. GUARENTE, 1994 Hap1 is nuclear but is bound to a cellular factor in the absence of heme. J. Biol. Chem. 269: 14643-14647.
45. ZITOMER, R. S., and C. V. LOWRY, 1992 Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol. Rev. 56: 1-11.