Evidence on N-acetyltransferase allele-associated metabolism of hydrazine in Japanese workers

Journal of Occupational and Environmental Medicine

Volumn 40, Issue 3, 1998, Pages 217-222

  Koizumi, Akio ^a   Nomiyama, Tetsuo ^b   Tsukada, Mikako ^a   Wada, Yasuhiko ^a   Omae, Kazuyuki ^b   Tanaka, Shigeru ^c   Miyauchi, Hiroyuki ^d   Imamiya, Shunichiro ^d   Sakurai, Haruhiko ^b  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KITASATO UNIVERSITY   (Japan)

^d Association of Industry Health   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOHYDRAZIDE; ACYLTRANSFERASE; CARCINOGEN; HYDRAZINE;

ACETYLATOR PHENOTYPE; ADULT; ARTICLE; BIOLOGICAL MONITORING; CARCINOGENESIS; CHEMICAL INDUSTRY; CONTROLLED STUDY; DRUG ACETYLATION; DRUG URINE LEVEL; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION;

ADULT; ALLELES; ARYLAMINE N-ACETYLTRANSFERASE; ASIAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; HUMANS; HYDRAZINES; JAPAN; MALE; MIDDLE AGED;

EID: 0031887232     PISSN: 10762752     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043764-199803000-00003     Document Type: Article

References (24)

1. International Agency for Research on Cancer. The evaluation of carcinogenic risk of chemicals to man. IARC Monograph No.4. Geneva: WHO; 1974:1-286.
2. American Conference of Governmental Industrial Hygienists Inc. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices 1996. Cincinnati, OH: ACGIH; 1996.
3. Bhalerao EB, Bhid SV. Levels of acetylhydrazines and rate of acetylation of isoniazid in adult tuberculosis patients. Indian J Physiol Pharmacol. 1985;29: 83-88.
4. Weber WW. The Acetylator Gene and Drug Response. New York: Oxford University Press; 1987.
5. Lin HJ, Han CY, Lin BK, Hardy S. Slow acetylator mutations in the human polymorphic N-acetyltrasnferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology. Am J Hum Genet. 1993;52:827-834.
6. Hein DW, Weber WW. Relationship between N-acetylator phenotype and susceptibility toward hydrazine-induced lethal central nervous system toxicity in the rabbit. Drug Metab Dispos. 1984;228: 588-592.
7. Cartwright R, Glasham R, Roger H, et al. Role of N-acetyltransferases phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer. Lancet 1982;ii:842-846.
8. Ilett KF, David B, Dethcon P, Castleden W, Kwa R. Acetylator phenotype in colorectal carcinoma. Cancer Res. 1991;47: 1466-1469.
9. Wohlleb JC, Hunter CF, Blass B, Kadlubar FF, Chu DS, Lang NP. Aromatic amine acetyltrasnferase as a marker for colorectal cancer: environmental and demographic association. Int J Cancer. 1990;46:22-30.
10. Silverman D, Hartge P, Morrison A, Devesa SS. Epidemiology of bladder cancer. Hematol Oncol Clin North Am. 1992;6: 1-30.
11. Vatsis KP, Weber WW, Bell DA, et al. Nomenclature for N-acetyltransferases. Pharmacogenetics. 1995:5:1-17.
12. Trimbrell JA, Harland SJ. Identification and quantification of hydrazine in the urine of patients treated with hydrazine. Clin Pharamacol Ther. 1979;26:81-88.
13. National Institute for Occupational Safety and Health. Manual of Analytical Methods: P&CAM 248 Hydrazine Compounds in Air. Cincinnati, OH: US Department of Health, Education, and Welfare; 1977:1:248-1-248-6.
14. SAS Institute Inc. SAS/STAT User's guide: Statistics, version 6.10. Cary, NC: SAS Institute Inc.; 1989.
15. Deutsche Forshungsgemeinshaft(DFG). List of MAK and BAT Values 1996. Weinheim, Germany: VCH Verlagsgesellshaft mbH; 1996.
16. Sunahara S, Urano M, Ogawa M. Genetical and geographic studies on isoniazid inactivation. Science. 1961;134:1530.
17. Trimbrell JA, Wright JM, Baillie TA. Monoacetylhydrazine as a metabolite of isoniazid in man. Clin Pharmacol Ther. 1977;22:602-608.
18. McKennis H, Weatherby JH, Witkin LB. Studies on the excretion of hydrazine and metabolites. J Pharmacol Exp Ther. 1955;114:385-390.
19. Wright JM, Timbrell JA. Factors affecting the metabolism of [14C] acetyl hydrazine in rats. Drug Metab Dispos. 1978: 6:561-566.
20. Kaneo Y, Iguchi S, Kubo H, Iwagiri N, Matsuyama K. Tissue distribution of hydrazine and its metabolites in rats. J Pharmacobiodyn. 1984;7:556-562.
21. Noda A, Sendo T, Ohno K, Goto S, Noda H, Hsu KY. Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats. Toxicol Lett. 1985;25:313-317.
22. Preece NE, Nicholson JK, Timbrell JA. Identification of novel hydrazine metabolites by 15N-NMR. Biochem Pharamacol. 1991;41:1319-1324.
23. Parkinson A. Biotransformation of xenobiotics. In: Klaasen CD, ed. Casarett & Doull's Toxicology: The Basic Science of Poisons, 5th ed. New York: McGraw-Hill; 1996:113-198.
24. Mitchell JR, Thorgiersson UP, Black M, et al. Increase incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites. Clin Pharamcol Ther. 1975;18:70-79.