Human platelets contain a novel 47 kDa thiol-oxidase having affinity for genomic sterol-regulatory sequence

Molecular and Cellular Biochemistry

Volumn 178, Issue 1-2, 1998, Pages 383-385

  Kaul, D ^a   Kaur, M ^a   Dhawan, V ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

47 kDa factor; CML patients; Lymphocytes; Platelets; SRE sequence affinity; Thiol oxidase activity

Indexed keywords

CHOLESTEROL; THIOL OXIDASE; THROMBOCYTE ENZYME;

ARTICLE; CHOLESTEROL METABOLISM; HOMEOSTASIS; HUMAN; HUMAN CELL; THROMBOCYTE;

BLOOD PLATELETS; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MOLECULAR WEIGHT; NUCLEAR PROTEINS; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON SULFUR GROUP DONORS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 0031886080     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006853001631     Document Type: Article

References (9)

1. Vitols S, Gahrton G, Bjorkholm M, Peterson C: Hypocholesterolemia in malignancy due to elevated low density lipoprotein receptor activity in tumor cells: Evidence from studies in Leukemia. Lancet 2 : 1150-1154, 1985
2. Buchwald H: Cholesterol inhibition, cancer and chemotherapy. Lancet 339: 1154-1156, 1992
3. Siperstein MD: Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth. J Lipid Res 25: 1462-1468, 1984
4. Vitols S, Gahrton G, Ost A, Peterson C: Elevated low density lipoprotein receptor activity in leukemic cells with monocytic differentiation. Blood 63: 1186-1193, 1984
5. Goel R, Kaul D, Varma S: Lymphocytes from CML patients lack 47 kDa factor having affinity for genomic sterol regulatory sequence. Leuk Res 20: 877-879, 1996
6. Goel R, Verma S, Kaul D: Sterol-dependent LDL receptor gene transcription in lymphocytes from normal and CML patients. Cancer Lett 107: 193-198, 1996
7. k' dependent signalling regulates LDL-receptor gene transcription. Mol Cell Biochem (in press), 1996
8. Kaul D, Dhawan V, Kaur M: Evidence and nature of a novel thioloxidase in human platelets. Mol Cell Biochem 159: 81-84, 1996
9. Bowen B, Steinberg J, Laemmli UK, Weintraub H: The detection of DNA binding proteins by protein blotting. Nuc Acid Res 8: 1-20, 1980