Improved outcome of adult acute lymphoblastic leukaemia by moderately intensified chemotherapy which includes a 'pre-induction' course for rapid tumour reduction: Preliminary results on 66 patients

British Journal of Haematology

Volumn 100, Issue 2, 1998, Pages 273-282

  Daenen, S ^a,d   Van Imhoff, G W ^a   Van Den Berg, E ^a,b   De Kam, P J ^b   Haaxma Reiche, H ^c   Vellenga, E ^d   Smit, J W ^c,d   Haue, R M ^c  

^a Department of Haematology ^*  (Netherlands)

^b Trial Coordination Center   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Acute lymphoblastic leukaemia; Cytarabine etoposide; Intensified chemotherapy; Pre induction; Risk factors

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DOXORUBICIN; ETOPOSIDE; MITOXANTRONE; PREDNISOLONE; VINCRISTINE;

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; FEMALE; GRANULOCYTOPENIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; MIDDLE AGED; REMISSION INDUCTION; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0031885914     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00559.x     Document Type: Article

References (42)

1. Baccarani, M., Corbelli, G., Amadori, S., Drenthe-Schonk, A., Willemze, R., Meloni, G., Lopez Cardozo, P., Haanen, C., Mandelli, F. & Tura, S. (1982) Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy: a study of 293 patients. Blood, 60, 677-684.
2. Bloomfield, C.D., Seeker-Walker, L.M., Goldman, A.I., Van den Berghe, IL, de la Chapelle, A., Ruutu, T., Alimena, G., Garson, O.H., Golomb, H.H., Rowley, J.D., Kaneko, Y., Whang-Pen, J., Prigogina, E., Philip, P., Sandberg, A.A., Lawler, S.D. & Mitelman, F. (1989) Six-year follow-up of the clinical signifance of karyotype in acute lymphoblastic leukemia. Cancer Genetics and Cytogenetics, 40, 171-185.
3. Camilla, B., Mahoney, D., Leventhal, B., Lauer, S.J., Shuster, J.J., Adair, S., Civin, C., Munoz, L., Steuber, P., Strother, D. & Kamen, B.A. (1994) Inlensive intravenous methotrexate and mercaplopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: a Pédiatrie Oncology Group study. Journal of Clinical Oncology, 12, 1383-1389.
4. Capizzi, R.L., Poole, M.. Cooper, M.R., Richards, F. II, Stuart, J.J., Jackson, D.V., Jr, White. D.R.. Spurr, C.L., Hopkins, J.O., Muss, H.B., Rudnick, S.A.. Wells, R., Gabriel, D. & Ross, D. (1984) Treatment of poor risk acute leukemia with sequential high-dose AraC and asparaginase. Blood, 63, 694-700.
5. Childhood ALL Collaborative Group (1996) Duration and intensitiy of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12000 randomised children. Lancet. 347, 1783-1788.
6. Cuttner, J., Mick, R., Budman, D.R., Mayer, R., Lee, E.J., Henderson, E.S., Weiss, R.B., Paciucci, P.A., Sobol, R., Davey, F., Bloomfield, C. & Schiffer, C. (1991) Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB study. Leukemia, 5, 425-431.
7. Dahl, G.V., Rivera, G.K., Look, A.T., Hustu, H.O., Kalwinsky, D.K., Abromowitch, M., Mirro, J., Ochs, J., Murphy, S.B., Dodge, R.K. & Pui, C-H. (1987) Tenoposide plus cytarabine improves outcome in childhood acute lymphoblastic leukemia with a leukocyte count 100xl09/I. Journal of Clinical Oncology, 5, 1015-1021.
8. Dekker, A., van 't Veer, M.B., Sizoo, W., Haak, H.L., van der Lelic, J., Ossenkoppele, G., Huijgens, P.C., Schouten, U.C., Sonneveld, P., Willemze, R., Verdonck, L.F., van Putten, \V.L.J. & Löwenberg, B. (1997) Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Journal of Clinical Oncology, 15, 476-482.
9. Ellison. R.R., Mick, R., Cuttner, J., Schiffner, C.A., Silver, R.T., Henderson, E.S., Woliver, T., Royston, I., Davey, F.R., Glicksman, A.S., Bloomfield. CD. & Holland, J.F. (1991) The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. Journal of Clinical Oncology, 9, 2002-2015.
10. Evensen, S.A., Brinch, G., Tjonnfjord, P., Stavem. P. & \Visloff, F. (1994) Estimated 8-year survival of more than 40% in a population-based study of 79 adult patients with acute lymphoblastic leukaemia. British Journal of Haematology, 88, 88-93.
11. Fière, D., Lepage, E., Sebban. C, Boucheix, C., Gisselbrecht, G.. Vernant, J-P., Varet, B., Braustet, A., Cahn, J.Y., Rigal-Huguet, F., Witz, F., Michaux, J-L., Michallet, M. & Reiffers, J., for the French Group on Therapy for Acute Lymphoblastic Leukemia (1993) Adult acute lymphoblastic leukemia: a multi-centric randomized trial testing bone marrow transplantation as postremission therapy. Journal of Clinical Oncology, 11, 1990-2001.
12. Gaynor, J., Chapman, D., Little, C., McKenzie, S., Miller. W, Andreeff, M.. Arlin. Z., Berman, E., Kempin. S., Gee, T. & Clarkson, B. (1988) A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969. Journal of Clinical Oncology, 6, 1014-30.
13. Gilchrist, G.S., Tubergen, D.G., Sather, H.N., Coccia, P.P. & O'Brien, R.T. (1994) Low numbers of cerebrospinal fluid blasts at diagnosis do not predict for the development of central nervous system leukemia in children with intermediate-risk acute lymphoblastic leukemia: a Childrens Cancer Group report. Journal of Clinical Oncology. 12, 2594-2600.
14. GIMEMA ALL 0183 (1989) A multicentric study on adult acute lymphoblastic leukaemia in Italy. British Journal of Haematology, 71, 377-386.
15. Groupe Française de Cytogénétique Hématologique (1996) Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hématologie findings and outcome. A collaborative study of the Groupe Française de Cytogénétique Hématologique. Blood. 87, 3135-3142.
16. Haaxma-Reiche, H. & Daenen, S. (1988) Acute lymphoblastic leukemia in adults: results of intraventricular maintenance chemotherapy for central nervous system prophylaxis and treatment. European Journal of Cancer and Clinical Oncology, 24, 615-620.
17. Hoelzer, D. (1996) Acute lymphoblastic leukaemia in adults. Education Sessions of the Second Meeting of the European Ilaematologij Association, Paris. France, 29 May to 1 June. pp. 86-90. Blackwell Science, Oxford.
18. Hoelzer, D.. Thiel, E., Loeffler, H., Buchner, T., Ganser, A., Heil, G-, Koch. P., Freund, M.'. Diedrich, H., Ruhl, H., Maschmeier, G.. Lipp, T., Nowrousian, M.R.. Burkert, M.. Gereda, D., Pralle, H., Müller, U. Lunsken. Ch., Fülle, H., Ho. A.D., Küchler, R., Busch, F.W.. Schneider, W., Görg. Ch., Emmerich, B., Braumann, D., Vaupel, H.A., von Paleske, A., Bartels, H., Neiss, A. & Messener, D. (1988) Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood. 71, 123-131.
19. Hoelzer, D., Thiel, E., Ludwig. W.D., Loftier, H., Buchner, Th., Freund, M., Hiddemann, W., Maschmeyer, G., Völkers, B., Gokbuget, N. & Aydemir, U., for the German Adult ALL Study Group (1993) Follow-up of the first two successive German multi-centre trials for adult ALL (01/81 and 02/84). Leukemia. 7, (Suppl. 2), S130S134.
20. Hussein, K.K.. Dahlberg, J., Head, D., Waddell, C.C., Dabisch, L., Weick. J.K., Morrison, F., Saiki, J.H., Metz, S.E., Grever, M.R., Boldt. D., and the Southwest Oncology Group (1989) Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy. Blood, 73, 57-63.
21. Kantarjian. U.M.. O'Brien, 0., Smith, T., Estey, E.H., Beran, M., Preti, A., Pierce, S. & Keating, M. (1994) Acute lymphocytic leukaemia in the elderly: characteristics and outcome with the vincristineadriamycin-dexamethasone (VAD) regimen. British Journal of Haematologij, 88, 94-100.
22. Larson, R.A., Dodge, R.K., Burns, C.P., Lee, E.J., Stone, R.M., Schulman, P., Duggan, D., Davey, F.R., Sobol, R.E.. Frankel, S.R., Hooberman, A.L., U'estbrook, C.A., Arthur, D.C., George, S.L., Bloomfield. C.D. & Schiller, C.A. (1995) A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 8811. Blood, 85, 2025-2037.
23. Linker, C.A.. Levitt, L.J., O'Donnell. M., Forman, SJ. & Ries, C.A. (1991) Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report. Blood, 78, 2814-2822.
24. Mahmoud, H.H., Rivera, G.K., Hancock, M.L., Krance, R.A.. Kun, L.E., Behm. EG., Ribeiro, R.C., Sandlund, J.T., Crist, W.M. & Pui, C.H. (1993) Low leukocyte counts with blast cells in cerebrospinal fluid of children with newly diagnosed acute lymphoblastic leukemia. New England Journal of Medicine. 329, 314-319.
25. Mandelli. E, Annino, L., Vegna, M.L., Ferrari, S., Cioli, S.. Chierichini, A., Del Poeta, G., Fabbiano, E, Falda, M., Ferrara, E, Invernizzi, R., Ladogana, S., Recchia, A., Montillo, M., Sica, S., Specchia, G., Tabilio, A., Zagonel, V. & Baccarani. M., GIMEMA Group (1996) Adult acute lymphoblastic leukemia (ALL): results of the Gimema All 0288 trial. Abstracts of papers presented at the Second Meeting of the European Haematology Association, Paris, France, 29 May to 1 June. British Journal of Ilaematology. 93, (Suppl. 2), 144.
26. Niemeyer, C.M., Gelber, R.D., Tarbell, N.J.. Donnelly, M.. Clavell, L.A., Blattner, S.R., Donahue, K., Cohen, H.J. & Sallan, S.E. (1991) Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update). Blood, 78, 2514-2519.
27. Powles, R., Mehta. J., Singhal, S., Horta, C., Tait. D.. Milan, S., Pollard, C., Lumley, H., Matthey, P., Shirley. J., Williams, H., Samaratunga, !.. Lakhani, A., Millar, J. & Treleaven, J. (1995) Autologous bone marrow transplantation and peripheral blood stem cell transplantation for adult acute lymphoblastic leukemia in first remission: 50 cases from a single center. Bone Marrow Transplantation, 16, 241-247.
28. Pui, C-IL, Dodge, R.K., Dahl. G.V.. Rivera, G., Look, A.T., Kahvinsky, D., Bowman, W.P., Ochs, J., Abromowitch, M., Mirro, J. & Murphy, S.B. (1985) Serum lactate dehydrogenase level has prognostic value in childhood acute lymphoblastic leukemia. Blood, 66, 778-782.
29. Pui. C-H., Ribeiro, R.C., Hancock, M.L., Rivera. G.K., Evans, W.E., Raimondi, S.C., Head, D.R.. Behm, EG., Mahmoud, M.H., Sandlund, J.T. & Crist, W.M. (1991) Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. New England Journal of Medicine, 325, 16821687.
30. Radford, J.E., Jr, Burns, C.P., Jones, M.P., Gingrich, R.D., Kemp, J.D., Edwards, R.W., McFadden, D.B., Dick, ER. & Wen, B-C. (1989) Adult acute lymphoblastic leukemia: results of the Iowa HOP-L protocol. Journal of Clinical Oncology. 7, 58-66.
31. Rivera, G.K., Raimondi, S.C., Hancock, M.L., Behm, E.G., Pui, C-H., Abromowitch, M., Mirro, J., Jr, Ochs, J.S., Look, A.T., Williams. D.L., Murphy, S.B.. Dahl, G.V., Kalwinsky, O.K., Evans, W.E., Kun, L.E.. Simone, J.V. & Crist, W.M. (1991) Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet, 337, 61-66.
32. Scherrer, R Bettelheim, P., Geissler, K., Jäger, U., Knöbl, P., Kyrie, P.A., Laczika, K Mittelbauer, G., Neumann, B., Schneider. B., Schwarzinger, I. & Lechner, K. (1994) High efficacy of the German multicenter ALL (GMALL) protocol for treatment of adult acute lymphoblastic leukemia (ALL): a single-institution study. Annals of Hematologij. 69, 181-188.
33. Schwartz. S.A., Morgenstern, B. & Capizzi. R.L. (1982) Scheduledependent synergy and antagonism between high-dose 1-jSarabinofuranosylcytosine and asparaginase in the LSI78Y murine leukemia. Cancer Research. 42, 2191-2197.
34. Sebban, C., Lepage, E.. Vermant, J.P., Gluckman, E., Altai, M., Reiffers, J., Sutton. L., Racadot, E.. Michallet. M., Maraninchi, D., Dreyfus, F. & Fiere, D., for the French Group of Therapy of Adult Acute Lymphoblastic Leukemia (1994) Allogeneic bone marrow transplantation in adult acute lymphoblastic leukemia in first complete remission: a comparative study. French Group of Therapy of Adult Acute Lymphoblastic Leukemia. Journal of Clinical Oncology. 12, 2580-2587.
35. Seeker-Walker, L.M., Craig, J.M., Hawkins, J.M. & Hoffbrand, A.V. (1991) Philadelphia positive acute lymphoblastic leukaemia in adults: age distribution, BCR breakpoint and prognostic significance. Leukemia. 5, 196-199.
36. Seriu, T., Yokota, S., Nakao, M.. Misawa, S., Takaue, Y., Koizumi, S., Kawai, S. & Fujimoto, T. (1995) Prospective monitoring of minimal residual disease during the course of chemotherapy in patients with acute lymphoblastic leukemia, and detection of contaminating tumor cells in peripheral blood stem cells for autotransplantation. Leukemia, 9, 615-623.
37. Spath-Schwalbe, E., Heil, G. & Heimpel, II. (1994) Acute lymphoblastic leukemia in patients over 59 years of age: experience in a single center over a 10-year period. Annals of Hematology, 69, 292-296.
38. Stryckmans, L., de Witte, Th., Marie, J.P., Fillet, G., Peetermans. M., Bury, J., Muus, P., Andrien, J.M., Hayat. M.. Jaksic, B., Labor, B., Debusscher, L., Solbu, G., Sociu. S. & Zittoun, R., for the EORTC Leukemia Cooperative Group (1992) Therapy of adult ALL; overview of two successive EORTC studies: (ALL-2 and ALL-3). Leukemia. 6, (Suppl. 2), 199-203.
39. Taylor, P.R., Reid, M.M., Bown, N., Hamilton, PJ. & Proctor. SJ. (1992) ALL inpatients aged 60 years and over: a population-based study of incidence and outcome. Blood. 80, 1813-1817.
40. Weiss, M., Telford. P.. Kempin. S-, Kutz, A., Logoloff. H., Gee, T., Berman, E., Scheinberg, D., Little, C. & Gaynor, J. (1993) Severe toxicity limits intensification of induction therapy for acute lymphoblastic leukemia in older patients. Leukemia, 7, 832-837.
41. Wernli. M.. Tichelli, A., von Fliedner, V., Brun del Re, G., Chapuis, B., Fey, M.F., Fopp, M.. Gmur. J.. Grob. J-P., Jacky, E., Pedrazzini. A., Schmid, L., Senn, H.-J.. Tobler. A. & Gratwohl, A., from the Working Party on Leukaemia of the Swiss Group for Epidemiology and Clinical Cancer Research (SAKK) (1994) Intensive induction/ consolidation therapy without maintenance in adult acute lymphoblastic leukaemia: a pilot assessment. British Journal of Haematology. 87, 39-43.
42. Zhang. M.J., Hoelzer. D., Horowitz, M.M.. Gale, R.P., Messener, D.. Klein, J.P., Loffler. H.. Sobocinski, K.A., Thiel, E. & Weisdorf, D.J. (1995) Long-term follow-up of adults with acute lymphoblastic leukemia in first remission treated with chemotherapy or bone marrow transplantation. The ALL XVorking Committee. Aimais of Internal Medicine. 123, 428-431.