Skin microcirculation in patients with Type I diabetes with and without neuropathy after neurovascular stimulation

Clinical Science

Volumn 94, Issue 3, 1998, Pages 255-261

  Forst, Thomas ^a   Pfützner, Andreas ^a   Kunt, Thomas ^a   Pohlmann, Thomas ^a   Schenk, Ulrike ^a   Bauersachs, Rupert ^a   Küstner, Ernst ^a   Beyer, Jürgen ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Diabetic neuropathy; Neurogenic inflammation; Nutritive capillary blood flow; Total skin blood flow; Type I diabetes

Indexed keywords

ACETYLCHOLINE;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; CAPILLAROSCOPY; CAPILLARY FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; FEMALE; HALLUX; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LASER DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; NEUROGENIC INFLAMMATION; PRIORITY JOURNAL; SKIN BLOOD FLOW;

EID: 0031885442     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0940255     Document Type: Article

References (43)

1. Rayman G, Williams SA, Spencer PD, Smaje LH, Wise PH, Tooke JE. Impaired microvascular response to minor skin trauma in type I diabetes. Br Med J 1986; 292: 1295-8.
2. Rayman G, Hassan A, Tooke JE. Blood flow in the skin of the foot related to posture in diabetes mellitus. Br J Med 1986; 292: 87-90.
3. Walmsley D, Wales JK, Wiles PG. Reduced hyperaemia following skin trauma: evidence for an impaired microvascular response to injury in the diabetic foot. Diabetologia 1989; 32: 736-9.
4. Stevens MJ, Edmonds ME, Foster AVM, Douglas SLE, Watkins PJ. Paradoxical blood flow responses in the diabetic neuropathic foot: an assessment of the contribution of vascular denervation and microangiopathy. Diabetic Med 1992; 9: 49-54.
5. Shore AC, Price KJ, Sandema DD, Tripp JH, Tooke JE. Posturally induced vasoconstriction in diabetes mellitus. Arch Dis Child 1994; 70: 22-6.
6. Boulton AJM, Scarpello JHB, Ward JD. Venous oxygenation in the diabetic neuropathic foot: evidence of arteriovenous shunting. Diabetologia 1982; 22: 6-8.
7. Corbin DOC, Young RJ, Morrison DC, et al. Blood flow in the foot, polyneuropathy and foot ulceration in diabetes mellitus. Diabetologia 1987; 30: 468-73.
8. Uccioli L, Mancini L, Giordano A, Solini A, Magnani P, Manto A. Lower limb, arteriovenous shunts, autonomic neuropathy and diabetic foot. Diabetes Res Clin Pract 1992; 16: 123-30.
9. Henrikson O, Paaske WP. Local regulation of blood flow in the peripheral tissue. Acta Chir Scand 1980; 502: 63-74.
10. Parkhouse N, Le Quesne PM. Quantitative objective assessment of peripheral nociceptive C fibre function. J Neurol Neurosurg Psychiatry 1988, 51: 28-34.
11. Parkhouse N, Le Quesne PM. Impaired neurogenic vascular response in patients with diabetes and neuropathic foot lesions. N EnglJ Med 1988; 318: 1306-9.
12. Walmsley D, Wiles PG. Early loss of neurogenic inflammation in the human diabetic foot. Clin Sci 1991; 80: 605-10.
13. Benarroch EE, Low PA. The acetylcholine-induced flare response in evaluation of small fibre dysfunction. Ann Neurol 1991; 29: 590-5.
14. Morris SJ, Kunzek S, Shore AC. The effect of acetylcholine on finger capillary pressure and capillary flow in healthy volunteers. J Physiol 1996; 494: 307-13.
15. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (London) 1988; 27: 373-6.
16. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endotheltum-dependent vascular retaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22-7.
17. Wahlberg E, Jörneskog G, Olofsson P, Swedenborg J, Fagrell B. The influence of reactive hyperaemia and leg dependency on skin microcirculation in patients with peripheral arterial occlusive disease (PAOD), with and without diabetes. VASA 1990; 19: 301-6.
18. Bongard O, Fagrell B. Discrepancies between total and nutritional skin microcirculation in patients with peripheral arterial occlusive disease. VASA 1990; 19: 105-11.
19. Henrich H, Johnsen PC. Influence of arterial pressure on reactive hyperaemia in skeletal muscle capillaries. Am J Physiol 1978; 234: 352-7.
20. McVeigh GE, Brennan GM, Johnston GD, et al. Impaired endothelium-dependent vasodilatation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992; 35: 771-6.
21. Smits P, Kapma JA, Jacobs MC, Luttermann J, Thien T. Endothelium-dependent vascular relaxation in patients with type I diabetes. Diabetes 1993; 42: 148-53.
22. Jörneskog G, Brismar K, Fagrell B. Skin capillary circulation is more impaired in the toes of diabetic than nondiabetic patients with peripheral vascular disease. Diabetic Med 1995; 12: 36-11
23. Flynn MD, Edmonds ME, Tooke JE, Watkins PJ. Direct measurement of capillary blood flow in the diabetic neuropathic foot Diabetologia 1988; 31: 652-6.
24. Jörneskog G, Brismar K, Fagrell B. Skin capillary circulation severely impaired in toes of patients with IDDM, with and without late diabetic complications. Diabetologia 1995; 38: 474-80.
25. Ziegler D, Laux G, Dannehl K, et al. Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure response. Diabetic Med 1992; 9: 166-75.
26. Claus D, Mustafa C, Vogel W, Herz M, Neundörfer B. Assessment of diabetic neuropathy: definition of norm and discrimination of abnormal nerve function. Muscle Nerve 1993; 16: 757-68.
27. Bircher A, de Boer EM, Agner T, Wahlberg JE, Serup J. Guidelines for measurement of cutaneous blood flow by laser doppler flowrnetry. Contact Dermatitis 1994; 30: 65-72.
28. Forst T, Pfützner A, Arin M, et al. Effect of transcutaneous electrical nerve stimulation on total skin microcirculation in the diabetic foot Diabetologia 1995; 38: A79.
29. Tooke JE, Östergreen J, Fagrell B. Synchronous assessment of human skin microcirculation by laser Doppler flowmetry and dynamic capillaroscopy. Int J Microcirc Clim Exp 1983; 2: 277-84.
30. Rendell M, Bergmann T, O'Donnell G, Drobny ED, Borgos J, Bonner RF. Microvascular blood flow, volume, and velocity measured by laser doppler techniques in IDDM. Diabetes 1989; 38: 819-24.
31. Shami SK, Chittenden SJ. Microangiopathy in diabetes mellitus: II. Features complications and investigation. Diabetes Res 1991; 17: 157-68.
32. Tooke JE. Methodologies used in the study of the microcirculation in diabetes mellitus. Diabetes Metab Rev 1993; 9: 57-70.
33. Watkins PJ, Edmonds ME. Sympathetic nerve failure in diabetes. Diabetologia 1983; 25: 73-7.
34. Lembeck F. Sir Thomas Lewis nocifensor system, histamine and substance-P-containing primary afferent nerves. Trends Neurosci 1983; 6: 106-8.
35. Westermann RA, Widdop RE, Hogan C, Zimmet P. Noninvasive tests of neurovascular responses in diabetes mellitus. Neurosci Lett 1987; 81: 177-82.
36. Westermann R, Widdop R, Low A, Hannaford J, Kozak W, Zimmet P. Noninvasive tests of neurovascular function: reduced axon reflex responses in diabetes mellitus of man and streptozotocin diabetes of the rat Diabetes Res Clin Pract 1988; 5: 49-54.
37. Vanhoutte PM, Levy MN. Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system. Am J Physiol 1980; 238: H275-81.
38. Douglas WW, Ritchie JM. The excitatory action of acetylcholine on cutaneous non-myelinated fibres. J Physiol 1960; 150: 501-14.
39. Rayman G, Williams S, Hassan A, Gamble J, Tooke JE. Capillary hypertension and overperfusion in the feet of young diabetics. Diabetics Med 1985; 2: 304
40. Sandemann DD, Shore AC, Tooke JE. Relation of skin capillary pressure in patients with insulin dependent diabetes mellitus to complications and metabolic control. N Engl J Med 1992; 327: 760-4.
41. Flynn MD, Tooke JE. Aetiology of diabetic foot ulceration: a role for the microcirculation. Diabetic Med 1992; 8: 320-9.
42. Tooke JE. Microvascular function in human diabetes. Diabetes 1995; 44: 721-6.
43. Bollinger A, Frey J, Jäger K, FurrerJ, Seglias J, Siegenthaler W. Patterns of diffusion through skin capillaries in patients with long term diabetes. N Engl J Med 1982; 307: 1305-10.