Phosphodiesterase IV inhibitors synergistically potentiate relaxation induced by forskolin in guinea pig trachea

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 2, 1998, Pages 114-119

  Tanizawa, Makoto ^a   Watanabe, Takako ^a   Kume, Hiroaki ^a   Yamaki, Kenichi ^a   Miyamoto, Kenichi ^b   Takagi, Kenzo ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Airway smooth muscle; Forskolin; Phosphodiesterase inhibitors; Adrenoceptor

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; AMRINONE; BETA ADRENERGIC RECEPTOR; BRONCHODILATING AGENT; DENBUFYLLINE; FORSKOLIN; PHOSPHODIESTERASE IV INHIBITOR; TERBUTALINE; VINPOCETINE; ZAPRINAST;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATING ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; GUINEA PIG; IN VITRO STUDY; NONHUMAN; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

EID: 0031884361     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02187.x     Document Type: Article

References (37)

1. Tsukawaki M, Suzuki K, Suzuki R, Takagi K, Satake T. Relaxant effects of forskolin on guinea-pig tracheal smooth muscle. Lung 1987; 165: 225-37.
2. Giembycz MA, Dent G. Prospects for cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma. Clin. Allergy 1992; 22: 337-44.
3. Rinard GA, Jensen A, Puckett M. Hydrocortisone and isoproterenol effects on trachealis, cAMP, and relaxation. J. Appl. Physiol. 1983; 55: 1609-18.
4. Crokroft D, McParland CP, Britto SA, Swystun VA, Rutherford C. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993; 342: 833-7.
5. Sears MR, Taylor DR, Print CG et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990; 336: 1391-6.
6. Taylor DR, Sears MR, Herbison GP et al. Regular inhaled beta-agonist in asthma: Effects on exacerbations and lung function. Thorax 1993; 48: 134-8.
7. Barnes PJ. β-Adrenergic receptors and their regulation. Am. J. Respir. Crit. Care Med. 1995; 152: 838-60.
8. s on desensitization of beta-adrenergic receptors in tracheal smooth muscle. Am. J. Physiol. 1997; 273: L556-64.
9. Mullar MJ, Bear HP. Relaxant effects of forskolin in smooth muscle. Role of cyclic AMP. Naunyn Schmiedebergs Arch. Pharmacol. 1983; 332: 78-82.
10. Seamon KB, Daly JW. Forskolin: A unique diterpene activator of cyclic AMP-generating system. Adv. Cyclic Nucleotide Res. 1981; 4: 201-24.
11. Barnes PJ. Cyclic nucleotides and phosphodiesterases and airway function. Eur. Respir. J. 1995; 8: 457-62.
12. Michaeli T, Bloom TJ, Martins T et al. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J. Biol. Chem. 1993; 268: 12925-32.
13. Beavo JA. Multiple isozymes of cyclic nucleotide phosphodiesterase. In: Greengard P, Robison GA (eds). Advances in Second Messenger and Phosphoprorein Research. Raven Press, New York. 1988; 1-38.
14. Nicholson CD, Challiss RAJ, Shahid M. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci. 1991; 12: 19-27.
15. Thompson WJ. Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function. Pharmacol. Ther. 1991; 51: 13-33.
16. Dent G, Magnussen H, Rabe KF. Cyclic nucleotide phosphodiesterases in the human lung. Lung 1994; 172: 129-46.
17. Shahid M, Van Amsterdam RGM, De Boer J, Ten Berge RE, Nicholson CD, Zaagsma J. The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br. J. Pharmacol. 1991; 104: 471-7.
18. Torphy TJ, Undem BJ. Phosphodiesterase inhibitors: New opportunities for the treatment of asthma. Thorax 1991; 46: 512-23.
19. Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci. 1990; 11: 150-5.
20. Brunnée T, Engelstätter R, Steinijans VW, Kunkel G. Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma. Eur. Respir. J. 1992; 5: 982-5.
21. Baba K, Satake T, Takagi K, Tomita T. Effects of verapamil on the response of the guinea-pig tracheal muscle to carbachol. Br. J. Pharmacol. 1986; 88: 441-9.
22. Miyamoto K, Yamamoto Y, Kurita M et al. Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. J. Med. Chem. 1993; 36: 1380-6.
23. Sakai R, Konno K, Yamamoto Y et al. Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J. Med. Chem. 1992; 35: 4039-44.
24. Giembycz MA, Raeburn D. Putative substrates for cyclic nucleotide dependent protein kinases and the control of airway smooth muscle tone. J. Autonom. Pharmacol. 1991; 11: 365-98.
25. Ca channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J. Clin. Invest. 1994; 93: 371-9.
26. Howell RE. Multiple mechanisms of xanthine actions on airway reactivity. J. Pharmacol. Exp. Ther. 1993; 255: 1008-14.
27. Persson CGA, Andersson KE, Kjellin G. Effects of enprofylline and theophylline may show the role of adenosine. Life Sci. 1986; 38: 1057-72.
28. Gilman AG. G proteins: Transducers of receptor-generated signals. Annu. Rev. Biochem. 1987; 56: 615-49.
29. Murray KJ. Cyclic AMP and mechanisms of vasodilation. Pharmacol. Ther. 1990; 47: 329-45.
30. Torphy TJ, Undem BJ, Cieslinski LB, Luttmann MA, Reeves ML, Hay DWP. Identification, characterization and functional role of phosphodiesterase isoenzymes in human airway smooth muscle. J. Pharmacol. Exp. Ther. 1993; 265: 1212-23.
31. Miyamoto K, Kurita M, Sakai R, Sanae F, Wakusawa S, Takagi K. Cyclic nucleotide phosphodiesterase isoenzymes in guinea-pig tracheal muscle and bronchorelaxation by alkylxanthines. Biochem. Pharmacol. 1994; 48: 1219-23.
32. Qian Y, Naline E, Karlsson JA, Raeburn D, Advenier C. Effects of rolipram and siguazodan on the human isolated bronchus and their interaction with isoprenaline and sodium nitroprusside. Br. J. Pharmacol. 1993; 109: 774-8.
33. Tomkinson A, Karlsson JA, Raeburn D. Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing β-adrenoceptor subtypes. Br. J. Pharmacol. 1993; 108: 57-61.
34. Cortijo J, Bou J, Beleta S et al. Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Br. J. Pharmacol. 1993; 108: 562-8.
35. De Boer J, Philpott AJ, Van Amsterdam RGM, Shahid M, Zaagsma J, Nicholson CD. Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Biochemical and pharmacological analysis using selective inhibitors. Br. J. Pharmacol. 1992; 106: 1028-34.
36. Giembycz MA, Belvisi MG, Miura M, Peters MJ, Yacoub M, Barnes PJ. Cyclic nucleotide phosphodiesterases in human trachealis and the mechanical effect of isoenzyme-selective inhibitors. Am. Rev. Respir. Dis. 1992; 145: A378.
37. Shahid M, Philpott AJ, De Boer J, Zaagsma J, Nicholson CD. Cyclic nucleotide phosphodiesterase (PDE) isoenzyme activities in human peripheral bronchi. Br. J. Pharmacol. 1992; 105 (Suppl.): 128P.