The role of glucose metabolism in a pig heart model of short-term hibernation

Molecular and Cellular Biochemistry

Volumn 180, Issue 1-2, 1998, Pages 75-83

  Hacker, Timothy A ^a   Renstrom, Britta ^a   Nellis, Stephen H ^a   Liedtke, A James ^a  

^a University of Wisconsin Health   (United States)

Author keywords

Creatine kinase; Glucose metabolism; Mild sustained ischemia

Indexed keywords

CREATINE KINASE; FATTY ACID; GLUCOSE; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CORONARY ARTERY BLOOD FLOW; FATTY ACID METABOLISM; GLUCOSE METABOLISM; GLYCOLYSIS; HEART MUSCLE METABOLISM; HIBERNATION; ISCHEMIA; NONHUMAN; SWINE;

ANIMALS; FATTY ACIDS; GLUCOSE; GLYCOLYSIS; HEART; HIBERNATION; IODOACETATES; IODOACETIC ACID; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXYGEN CONSUMPTION; SWINE; TIME FACTORS;

ANIMALIA; SUS SCROFA;

EID: 0031884305     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006839022943     Document Type: Article

References (42)

1. Braunwald B, Rutherford JD: Reversible ischemce left ventricular dysfunction: Evidence for the 'hibernating myocardium'. J Am Coll Cardiol 8: 1467-1470, 1986
2. Rahimtoola SH: A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72 (suppl V): V-123-V-135, 1985
3. Shen Y-T, Vatner, SF: Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs: Hibernation or stunning? Circ Res 76: 479-488, 1995
4. Vanoverschelde J-LJ, Wijns W, Depre C, Essamri B, Heyndrickx GR, Borgers M, Bol A, Melin JA: Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium. Circulations 87: 1513-1523, 1993
5. Capasso JM, Li P, Anversa P: Nonischemic myocardial damage induced by nonocclusive constriction of coronary artery in rats. Am J Physiol 260: H651-H661, 1991
6. Canty JM, Klocke FJ: Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure. Circ Res 61(Suppl II): II107-II116, 1987
7. Liedtke AJ, Renstrom B, Nellis SH, Subramanian R: Myocardial function and metabolism in pig hearts following relief from chronic partial coronary stenosis. Am J Physiol 267: H1312-H1319, 1994
8. Pantely GA, Malone SA, Rhen WS, Anselone CG, Arai A, Bristow J, Bristow JD: Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res 67: 1481-1493, 1990
9. Arai AE, Pantely GA, Anselone CG, Bristow J, Bristow JD: Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res 69: 1458-1469, 1991
10. Fedele FA, Gewirtz H, Capone RJ, Sharaf B, Most AS: Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. Circulation 78: 729-735, 1988
11. Guth BD, Wisneski JA, Neese RA, White FC, Heusch G, Mazer D, Gertz EW: Myocardial lactate release during ischemia in swine: Relation to regional blood flow. Circulation 81: 1948-1958, 1990
12. Schaefer S, Schwartz GS, Wisneski JA, Trocha SD, Christoph I, Steinman SK, Garcia J, Massie BM, Weiner MW: Response of high-energy phosphates and lactate release during prolonged regional ischemia in vivo. Circulation 85: 342-349, 1992
13. Schulz R, Guth BD, Pieper K, Martin C, Heusch G: Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: A model of short-term hibernation. Circ Res 70: 1282-1295, 1992
14. Hoffmeister HM, Mauser M, Schaper W: Repeated short periods of regional myocardial ischemia: Effect on local function and high energy phosphate levels. Basic Res Cardiol 81: 361-372, 1986
15. Nicklas JM, Becker LC, Bulkley BH: Effects of repeated brief coronary occlusion on regional left ventricular function and dimension in dogs. Am J Cardiol 56: 473-478, 1985
16. Schulz R, Rose J, Martin C, Brodde O, Heusch G: Development of short-term myocardial hibernation. Its limitation by the severity of ischemia and inotropic stimulation. Circulation 88: 684-695, 1993
17. 18F-labeled flurodeoxyglucose and N-13 ammonia. Circulation 67: 766-778, 1983
18. Ratib O, Phelps ME, Haung S-C, Henze E, Selin CB, Schelbert HR: Positron tomography with deoxyglucose for estimating local myocardial glucose metabolism. J Nucl Med 23: 577-586, 1982
19. Branken R, Tillisch J, Schwaiger M, Child JS, Marshall R, Mandelkern M, Phelps ME, Schelbert HR: Regional perfusion, glucose metabolism, and wall motion in patients with chronic electrocardiographic Q wave infarctions: evidence for persistence of viable tissue in some infarct regions by positron emission tomography. Circulation 73: 951-963, 1986
20. Tillisch J, Broken R, Marshall R, Schwaiger M, Mandelkern M, Phelps ME, Schelbert HR: Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 314: 884-888, 1986
21. Liedtke AJ, Renstrom B, Nellis SH, Hall JL, Stanley WC. Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis. J Am Coll Cardiol 26: 815-25, 1995
22. Apstein CS, Eberli FR: Critical role of energy supply and glycolysis during short-term hibernation. Basic Res Cardiol 90: 2-4, 1995
23. Bricknell OL, Daries PS, Opie LH: A relationship between adenosine triphosphate, glycolysis and ischaemic contracture in the isolated rat heart. J Mol Cell Cardiol 13: 941-945, 1981
24. Liedtke AJ, DeMaison L, Eggleston AM, Cohen LM, Nellis SH: Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res 62: 535-542, 1988
25. Liedtke AJ, Nellis SH, Mjos OD: Effects of reducing fatty acid metabolism on mechanical function in regionally ischemic hearts. Am J Physiol 247: H387-H394, 1984
26. 14C]Deoxyglucose as markers of glycolysis in reperfused myocardium. Circ Res 71: 689-700, 1992
27. Nellis SH, Liedtke AJ, Renstrom B. Distribution of carbon flux within fatty acid utilization during myocardial ischemia and reperfusion. Circ Res 69: 779-790, 1991
28. Liedtke AJ, Nellis SH, Neely JR: Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine. Circ Res 43: 652-661, 1978
29. Fleischer WR: Enzymatic methods for lactic and pyruvic acids. In: RP MacDonald (ed). Standard Methods in Clinical Chemistry. Academic Press, New York, 1970, pp 245-259
30. Rovetto MJ, Lamberton WF, Neely JR: Mechanisms of glycolytic inhibition in ischemic rat hearts. Circ Res 37: 742-751, 1975
31. Huang XQ, Liedtke AJ: Alterations in fatty acid oxidation in ischemic and reperfused myocardium. Mol Cell Biochem 88: 145-153, 1989
32. Bradley DC, Kaslow HR: Radiometrie assays for glycerol, glucose, and glycogen. Anal Biochem 180: 11-16, 1989
33. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917, 1959
34. Solaro RJ, Pang DC, Briggs FN: The purification of cardiac myofibrils with Triton X-100. Biochim Biophys Acta 245: 259-262, 1971
35. Bradford MM: A rapid and sensitive method for the quantitiation of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
36. Jennings RB, Reimer KA, Steenbergen CJ, Schaper J: Total ischemia III: Effect of inhibition of anaerobic glycolysis. J Moll Cell Cardiol 21 (suppl 1): 37-54, 1989
37. Apstein CS, Deckelbaum L, Hagopian L, Hood WB: Acute cardiac ischemia and reperfusion: Contractility, relaxation, and glycolysis. Am J Physiol 235: H637-H648, 1978
38. Ruff RL, Weissman J: lodoacetate-induced contracture in rat skeletal muscle: Possible role of ADP. Am J Physiol 261: C828-C836, 1991
39. Vanoverschelde J-LJ, Janier MF, Bakke JE, Marshall DR, Bergmann SR: Rate of glycolysis during ischemia determines the extent of ischemic injury and functional recovery after reperfusion. Am J Physiol 267: H1785-H1794, 1994
40. 31P-NMR studies in the isolated blood perfused rat heart. Circulation 88: (Suppl 1) 1-13, 1993
41. Greenfield RA, Swain JL: Disruption of myofibrillar energy use: Dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium. Circ Res 60: 283-289, 1987
42. Hamman BL, Bittl JA, Jacobus WE, Allen PD, Spencer RS, Tian R, Ingwall JS: Inhibition of the creatine kinse reaction decreases the contractile reserve of isolated rat hearts. Am J Physiol 269: H1030-H1036, 1995