Clinical analysis of sampatrilat, a combined renal endopeptidase and angiotensin-converting enzyme inhibitor I: Assay in plasma of human volunteers by atmospheric-pressure ionisation mass-spectrometry following derivatisation with BF3-methanol

Journal of Pharmaceutical and Biomedical Analysis

Volumn 16, Issue 5, 1998, Pages 875-881

  Venn, Richard F ^a   Kaye, Barry ^a   MacRae, Paul V ^a   Saunders, Kenneth C ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Atmospheric pressure ionisation mass spectrometry; Clinical bioanalysis; Derivatisation; Plasma; Sampatrilat; UK 81,252

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PROTEINASE; SAMPATRILAT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; CLINICAL CHEMISTRY; CONTROLLED STUDY; DERIVATIZATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BIOLOGICAL AVAILABILITY; ENDOPEPTIDASES; HUMANS; KIDNEY; MASS SPECTROMETRY; MESYLATES; METHANOL; PROTEASE INHIBITORS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TYROSINE;

EID: 0031884215     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(97)00126-X     Document Type: Article

References (5)

1. Danser A.H.J. Expert Opinion in Investigational Drugs. 4:1995;753-757.
2. Kaye B., Clark M.W.H., Cussans N.J., Macrae P.V., Stopher D.A. Biol. Mass. Spectrom. 21:1992;585-589.
3. R.F. Venn, G. Barnard, B. Kaye, P.V. Macrae, K.C. Saunders, J. Pharm. Biomed. Anal. 16 (1997) in press.
4. Beresford A.P., Macrae P.V., Alker D., Kobylecki R.J. Arzneim.-Forsch. Drug Res. 39:1989;201-209.
5. Vu-Duc T., Vernay A. J. Pharm. Biomed. Anal. 10:1992;187-191.