Induction of aneuploidy by the antineoplastic drug estramustine in human lymphocytes

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 412, Issue 1, 1998, Pages 33-40

  Migliore, Lucia ^a   Cocchi, Leonardo ^a   Scarpato, Roberto ^a   Sbrana, Isabella ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Aneuploidy; Estramustine; Human lymphocyte

Indexed keywords

ANTINEOPLASTIC AGENT; ESTRAMUSTINE; VINBLASTINE SULFATE;

ANEUPLOIDY; ARTICLE; CHROMOSOME SATELLITE; CONTROLLED STUDY; CYTOGENETICS; DNA PROBE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MICRONUCLEUS TEST; MITOSIS INDEX; MITOSIS SPINDLE; NORMAL HUMAN; NUMERICAL CHROMOSOME ABERRATION; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; STRUCTURAL CHROMOSOME ABERRATION;

ADULT; ANEUPLOIDY; ANTINEOPLASTIC AGENTS, ALKYLATING; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; ESTRAMUSTINE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEUS TESTS; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTAGENICITY TESTS; SISTER CHROMATID EXCHANGE;

EID: 0031884195     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00165-4     Document Type: Article

References (21)

1. Björk P., Forsgren B., Gustafsson J.-Å., Pousette Å., Högberg B. Partial characterization and "quantitation" of a human prostatic estramustine-binding protein. Cancer Res. 42:1982;1935-1942.
2. Tew K.D., Erickson L.C., White G., Wang A.L., Schein P.S., Hartley-Asp B. Cytotoxicity of estramustine, a steroid-nitrogen mustard derivative, through non-DNA targets. Mol. Pharmacol. 24:1983;324-328.
3. Kruse E., Hartley-Asp B. The effect of estramustine, nor-nitrogen mustard and tauromustine on macromolecular labelling in the human prostatic tumor cell line 1013L. Pharmacol. Toxicol. 64:1989;9-13.
4. Hartley-Asp B. Estramustine-induced mitotic arrest in two human prostatic carcinoma cell lines DU 145 and PC-3. Prostate. 5:1984;93-100.
5. Kanje M., Deinum J., Wallin M., Ekström P., Edström A., Hartley-Asp B. Effect of estramustine phosphate on the assembly of isolated bovine brain microtubules and fast axonal transport in the frog sciatic nerve. Cancer Res. 45:1985;2234-2239.
6. 4 mouse cells and DU-145 human prostate carcinoma cells in vitro. Cancer Res. 48:1988;1842-1849.
7. Stearns M.E., Tew K.D. Estramustine binds MAP-2 to inhibit microtubule assembly in vitro. J. Cell Sci. 89:1988;331-342.
8. Stearns M.E., Wang M., Tew K.D., Binder L.I. Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells. J. Cell Biol. 107:1988;2647-2656.
9. Friden B., Rutberg M., Deinum J., Wallin M. The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Biochem. Pharmacol. 42:1991;997-1006.
10. Speicher L.A., Barone L., Tew K.D. Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines. Cancer Res. 52:1992;4433-4440.
11. Dahllöf B., Billström A., Cabral F., Hartley-Asp B. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 53:1993;4573-4581.
12. Sbrana I., Di Sibio A., Lomi A., Scarcelli V. C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons. Mutation Res. 287:1993;57-70.
13. Migliore L., Bocciardi R., Macrì C., LoJacono F. Cytogenetic damage induced in human lymphocytes by four vanadium compounds and micronucleus analysis by fluorescence in situ hybridization with a centromeric probe. Mutation Res. 319:1993;205-213.
14. Migliore L., Cocchi L., Scarpato R. Detection of the centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocyte micronucleus assay after treatment with four suspected aneugens. Mutagenesis. 11:1996;285-290.
15. Miller A.D., Adler I.-D. Suspect spindle poisons: analysis of c-mitotic effects in mouse bone marrow cells. Mutagenesis. 4:1989;208-215.
16. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutation Res. 285:1993;35-44.
17. Houghton J.A. Relationships between satellite association and the occurrence of non-disjunction in man. Mutation Res. 61:1979;103-114.
18. Friden B., Wallin M., Deinum J., Prasad V., Luduena R. Effect of estramustine phosphate on the assembly of trypsin-treated microtubules and microtubules reconstituted from purified tubulin with either Tau, MAP2, or the tubulin-binding fragment of MAP2. Arch. Biochem. Biophys. 257:1987;123-130.
19. Sheridan V.R., Speicher L.A., Tew K.D. The effect of estramustine on metaphase and anaphase in DU 145 prostatic carcinoma cells. Eur. J. Cell. Biol. 54:1991;268-276.
20. Valbo C., Bergenheim T., Bergh A., Grankvist K., Henriksson R. DNA fragmentation induced by the antimitotic drug estramustine in malignant rat glioma but not in normal brain - suggesting an apoptotic cell death. Br. J. Cancer. 71:1995;717-720.
21. P. Pellerano, M. Simili, Z. Cavalieri, C. Bolognesi, A. Abbondandolo, S. Bonatti, Effects of the anti-cancer drug estramustine on cell cycle and cell division, (1997) Environmen. Mol. Mutagenesis, submitted.