메뉴 건너뛰기




Volumn 19, Issue 1, 1998, Pages 39-43

Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats

Author keywords

2 hydroxyflutamide; Carbon tetrachloride poisoning; Flutamide; High pressure lipid chromatography; Liver; Pharmacokinetics

Indexed keywords

2 HYDROXYFLUTAMIDE; FLUTAMIDE; UNCLASSIFIED DRUG;

EID: 0031883560     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (9)
  • 1
    • 0016702122 scopus 로고
    • Disposition of a new, nonstenoid, antiandrogen, α, α, α-trifluoro-2-methyl-4′-nitro-m-propionotoluidide (Flutamide), in men following a single oral 200 mg dose
    • Katchen B, Buxbaum S. Disposition of a new, nonstenoid, antiandrogen, α, α, α-trifluoro-2-methyl-4′-nitro-m-propionotoluidide (Flutamide), in men following a single oral 200 mg dose. Clin Endocrinol Metab 1975; 41: 373-9.
    • (1975) Clin Endocrinol Metab , vol.41 , pp. 373-379
    • Katchen, B.1    Buxbaum, S.2
  • 2
    • 0024395046 scopus 로고
    • Single and multiple dose pharmacokinetic evaluation of flutamide in normal geriatric volunteers
    • Radwanski E, Perentesis G, Symchowicz S, Zampaglione N. Single and multiple dose pharmacokinetic evaluation of flutamide in normal geriatric volunteers. J Clin Pharmacol 1969; 29: 554-8.
    • (1969) J Clin Pharmacol , vol.29 , pp. 554-558
    • Radwanski, E.1    Perentesis, G.2    Symchowicz, S.3    Zampaglione, N.4
  • 3
    • 0023793128 scopus 로고
    • The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment
    • Schulz M, Schmoldt A. Donn F, Becker H. The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment. Eur J Clin Pharmacol 1968; 34: 633-7.
    • (1968) Eur J Clin Pharmacol , vol.34 , pp. 633-637
    • Schulz, M.1    Schmoldt, A.2    Donn, F.3    Becker, H.4
  • 4
    • 0025977295 scopus 로고
    • Steady-state hydroxyflutamide plasma levels after the administration of two dosage forms of flutamide
    • Asade RH, Prizont L, Muino JP, Tessler J. Steady-state hydroxyflutamide plasma levels after the administration of two dosage forms of flutamide. Cancer Chemother Pharmacol 1991; 27: 401-5.
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 401-405
    • Asade, R.H.1    Prizont, L.2    Muino, J.P.3    Tessler, J.4
  • 5
    • 0023925701 scopus 로고
    • Plasma levels of hydroxy-flutamide in patients with prostatic cancer receiving the combined hormonal therapy: An LHRH agonist and flutamide
    • Belanger A, Giasson M, Couture J, Dupont A, Cusan L, Labrie F. Plasma levels of hydroxy-flutamide in patients with prostatic cancer receiving the combined hormonal therapy: an LHRH agonist and flutamide. Prostate 1988; 12: 79-84.
    • (1988) Prostate , vol.12 , pp. 79-84
    • Belanger, A.1    Giasson, M.2    Couture, J.3    Dupont, A.4    Cusan, L.5    Labrie, F.6
  • 6
    • 0027986981 scopus 로고
    • Determination of flutamide and hydroxyflutamide in dog plasma by a sensitive high performance liquid chromatography method utilizing mid-bore chromatography
    • Farthing D, Sica D, Fakhry I, Walters DL, Cefali EA, Allan G. Determination of flutamide and hydroxyflutamide in dog plasma by a sensitive high performance liquid chromatography method utilizing mid-bore chromatography. Biomed Chromatogr 1994; 8: 251-4.
    • (1994) Biomed Chromatogr , vol.8 , pp. 251-254
    • Farthing, D.1    Sica, D.2    Fakhry, I.3    Walters, D.L.4    Cefali, E.A.5    Allan, G.6
  • 8
    • 0024459939 scopus 로고
    • Mechanism of the protective action of kopsinine against hepatotoxicity of carbon tetrachloride
    • Huang WY, Liu GT. Mechanism of the protective action of kopsinine against hepatotoxicity of carbon tetrachloride. Acta Pharmacol Sin 1989; 10: 461-4.
    • (1989) Acta Pharmacol sin , vol.10 , pp. 461-464
    • Huang, W.Y.1    Liu, G.T.2
  • 9
    • 85069421025 scopus 로고
    • Drug active metabolite and clinical monitoring
    • Li D. Drug active metabolite and clinical monitoring. New Drugs Clin Remedies 1967; 6: 102-6.
    • (1967) New Drugs Clin Remedies , vol.6 , pp. 102-106
    • Li, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.