Expression, purification, and encephalitogenicity of recombinant human myelin oligodendrocyte glycoprotein

Journal of Neurochemistry

Volumn 70, Issue 4, 1998, Pages 1593-1599

  Bettadapura, Jayaram ^a   Menon, Krishna K ^a   Moritz, Susanne ^a   Liu, Junliang ^a   Bernard, Claude C A ^a  

^a LA TROBE UNIVERSITY   (Australia)

Author keywords

Central nervous system; Demyelination; Multiple sclerosis; Myelin oligodendrocyte glycoprotein; Neurological impairment; Recombinant protein

Indexed keywords

AUTOANTIGEN; ENCEPHALITOGENIC PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MYELIN PROTEIN; RECOMBINANT PROTEIN; THROMBIN; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; DEMYELINATING DISEASE; ESCHERICHIA COLI; FEMALE; MOUSE; MOUSE STRAIN; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

EID: 0031882899     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70041593.x     Document Type: Article

References (40)

1. Abo S., Bernard C. C. A., Webb M., Johns T. G., Alafaci A., Ward L. D., Simpson R. J., and Kerlero de Rosbo N. (1993) Preparation of highly purified human myelin oligodendrocyte glycoprotein in quantities sufficient for encephalitogenicity and immunogenicity studies. Biochem. Mol. Biol. Int. 30, 945-958.
2. Albouz-Abo S., Wilson J. C., Bernard C. C. A., and Von Itzstein M. (1997) A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. Eur. J. Biochem. 246, 59-70.
3. Amiguet P., Gardinier M. V., Zanetta J.-P., and Matthieu J.-M. (1992) Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J. Neurochem. 58, 1676-1682.
4. Amor S., Groome N., Linington C., Morris M. M., Dornmair K., Gardinier M. V., Matthieu J.-M., and Baker D. (1994) Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J. Immunol. 153, 4349-4356.
5. Bernard C. C. A. (1976) Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility. J. Immunogenet. 3, 263-274.
6. Bernard C. C. A. and Kerlero de Rosbo N. (1992) Multiple sclerosis: an autoimmune disease of multifactorial etiology. Curr. Opin. Immunol. 4, 760-765.
7. Bernard C. C. A., Ichikawa M., Menon K., Slavin A., Ewing C., Johns T., Liu J., and Bettadapura J. (1996) Autoantigens in experimental autoimmune encephalitis and multiple sclerosis, in Frontiers in Multiple Sclerosis: Clinical Research and Therapy (Abramsky O. and Ovadia H., eds), pp. 61-70. Martin Dunitz, London.
8. Bernard C. C. A., Johns T., Slavin A., Ichikawa M., Ewing C., Liu J., and Bettadapura J. (1997) Myelin oligodendrocyte glycoprotein - a novel candidate autoantigen in multiple sclerosis. J. Mol. Med. 75, 77-88.
9. Bill R. M., Winter P. C., Mchale C. M., Hodges V. M., Elder G. E., Caley J., Flitsch S. L., Bicknell R., and Lappin T. R. T. (1995) Expression and mutagenesis of recombinant human and murine erythropoietins in Escherichia coli. Biochim. Biophys. Acta 1261, 35-43.
10. Devaux B., Enderlin F., Wallner B., and Smilek D. E. (1997) Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide. J. Neuroimmunol. 75, 169-173.
11. Gardinier M. V., Amiguet P., Linington C., and Matthieu J.-M. (1992) Myelin/oligodendrocyte glycoprotein is a unique member of immunoglobulin superfamily. J. Neurosci. Res. 33, 177-187.
12. Hartman J., Daram P., Frizzell A. R., Rado T., Benos D. J., and Sorcher E. J. (1992) Affinity purification of insoluble recombinant fusion proteins containing glutathione-S-transferase. Biotechnol. Bioeng. 39, 828-832.
13. Hilton A. A., Slavin A., Hilton D. J., and Bernard C. C. A. (1995) Cloning and molecular characterization of human myelin oligodendrocyte glycoprotein. J. Neurochem. 65, 309-318.
14. Hindges R. and Hubscher U. (1995) Production of active mouse DNA polymerase in bacteria. Gene 158, 241-246.
15. Ichikawa M., Johns T. G., Liu J., and Bernard C. C. A. (1996a) Analysis of the fine B cell specificity during chronic relapsing course of a MS-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J. Immunol. 157, 919-926.
16. Ichikawa M., Johns T. G., Adelmann M., and Bernard C. C. A. (1996b) Antibody response in Lewis rats injected with myelin oligodendrocyte glycoprotein derived peptides. Int. Immunol. 8, 1667-1674.
17. Johns T. G. and Bernard C. C. A. (1997) Binding of component C1q to myelin oligodendrocyte glycoprotein - a novel mechanism for regulatory CNS inflammation. Mol. Immunol. 34, 33-38.
18. Johns T. G., Kerlero de Rosbo N., Menon K., Abo S., Gonazales M. F., and Bernard C. C. A. (1995) Demyelinating encephalomyelitis resembling multiple sclerosis after immunisation with a peptide from myelin oligodendrocyte glycoprotein. J. Immunol. 154, 5536-5541.
19. Kerlero de Rosbo N., Honegger P., Lassmann H., and Matthieu J.-M. (1990) Demyelination induced in aggregating brain cell cultures by a monoclonal antibody against myelin/oligodendrocyte glycoprotein. J. Neurochem. 55, 583-587.
20. Kerlero de Rosbo N., Milo R., Lees M. B., Burger D., Bernard C. C. A., and Ben-Nun A. (1993) Reactivity to myelin antigens in multiple sclerosis. J. Clin. Invest. 92, 2602-2607.
21. Kerlero de Rosbo N., Mendel I., and Ben-Nun A. (1995) Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Eur. J. Immunol. 25, 985-993.
22. Kim H. S. and Hong H. J. (1995) Efficient expression, purification and characterization of hepatitis B virus pre S1 protein from Escherichia coli. Biotechnol. Lett. 17, 871-876.
23. Laemmli U. K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227, 680-685.
24. Lassmann H. and Linington C. (1987) The role of antibodies against myelin surface antigens in demyelination in chrome EAE, in A Multidisciplinary Approach to Myelin Diseases (Crescenzi G. S., ed), pp. 219-225, Plenum Press, New York.
25. Lebar R., Boutry J. M., Vincent C., Roubineaux R., and Voisin G. A. (1976) Studies on autoimmune encephalomyelitis in guinea pig. II. An in vitro investigation on the nature, properties and specificity of serum demyelinating factor. J. Immunol. 116, 1439-1446.
26. Lebar R., Lubetzki C., Vincent C., Lombrail P., and Boutry J. M. (1986) The M2 antigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane. Clin. Exp. Immunol. 66, 423-443.
27. Linington C., Webb M., and Woodhams P. L. (1984) A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody. J. Neuroimmunol. 6, 387-396.
28. Linington C., Bradl M., Lassmann H., Brunner C., and Vass K. (1988) Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against myelin/oligodendrocyte glycoprotein. Am. J. Pathol. 130, 443-454.
29. Liu J. (1997) Immunological characterization of a novel MS-like disease induced by oligodendrocyte glycoprotein in murine models. Ph.D. thesis, La Trobe University, Victoria, Australia.
30. Mendel I., Kerlero de Rosbo N., and Ben-Nun A. (1995) A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor Vβ expression of encephalitogenic T cells. Eur. J. Immunol. 25, 1951-1959.
31. Pham-Dinh P., Allinquant B., Ruberg M., Della Gaspera B., Nussbaum J.-L., and Dautigny A. (1994) Characterization and expression of the cDNA coding for human myelin/oligodendrocyte glycoprotein. J. Neurochem. 63, 2353-2356.
32. Raine C. S. (1990) Demyelinating diseases, in Textbook of Neuropathology (Davis R. L. and Robertson D., eds), pp. 535-620. Williams & Wilkins, Baltimore.
33. Ruhert J. (1992) Human T cell recognition of myelin basic protein peptides, in Myelin: Biology and Chemistry (Martenson R. E., ed), pp. 833-847. CRC Press, Boca Raton.
34. Sambrook J., Fritsch E., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edit. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
35. Schluesener H. J., Sobel R. A., Linington C., and Weiner H. L. (1987) A monoclonal antibody against myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J. Immunol. 139, 4016-4021.
36. Slavin A., Johns T., Orian J., and Bernard C. C. A. (1997) Regulation of myelin oligodendrocyte glycoprotein in different species throughout development. Dev. Neurosci. 19, 69-78.
37. Smith D. B. and Johnson K. S. (1988) Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67, 31-40.
38. Steinmann L. (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85, 299-302.
39. Sun J., Link H., Olsson T., Xiao B.-G., Andersson G., Ekre H.-P., Linington C., and Diener P. (1991) T and B cell responses to myelin oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 146, 1490-1495.
40. Willenborg D. O., Fordham S., Bernard C. C. A., Cowden W. B., and Ramshaw I. A. (1996) IFN-γ plays a critical down regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein induced autoimmune encephalomyelitis. J Immunol. 157, 3223-3227.