Acute changes in urine protein excretion may predict chronic ifosfamide nephrotoxicity: A preliminary observation

Cancer Chemotherapy and Pharmacology

Volumn 41, Issue 5, 1998, Pages 413-416

  MacLean, Fergus R ^a   Skinner, Roderick ^a   Hall, Andrew G ^a   English, Martin ^a   Pearson, Andrew D J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Children; Ifosfamide; Nephrotoxicity; Proteinuria; Tamm Horsfall protein

Indexed keywords

ACICLOVIR; AMIKACIN; AMPHOTERICIN; IFOSFAMIDE; VANCOMYCIN;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; SARCOMA;

ADOLESCENT; ANTINEOPLASTIC AGENTS, ALKYLATING; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HUMANS; IFOSFAMIDE; INFANT; KIDNEY; MALE; MUCOPROTEINS; NEOPLASMS; PROTEINURIA;

EID: 0031882650     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050759     Document Type: Article

References (22)

1. Al Sheyyab M, Stevens M, Worthington D, Beetham R (1990) Retinol binding protein in the assessment of ifosfamide tubular nephrotoxicity (abstract). Med Pediatr Oncol 18: 406
2. Al Sheyyab M, Worthington D, Beetham R, Stevens M (1993) The assessment of subclinical ifosfamide-induced renal tubular toxicity using excretion of retinol binding protein. Pediatr Hematol Oncol 10: 119
3. Boddy AV, Yule SM, Wyllie R, Price L, Pearson ADJ, Idle JR (1993) Pharmacokinetics and metabolism of ifosfamide administered as a continuous infusion in children. Cancer Res 53: 3758
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248
5. Burk CD, Restaino I, Kaplan BS, Meadows AT (1990) Ifosfamide-induced renal tubular dysfunction and rickets in children with Wilm's tumour. J Pediatr 117: 331
6. Dawney A, Lucey MB, Thornley C, Beetham R, Neuberger JM, Cattell WR, Williams R (1988) The effects of long-term low dose cyclosporin A on renal tubular function in humans. Transplant Proc 20 [Suppl 3]: 725
7. Heney D, Wheeldon J, Rushworth P, Chapman C, Lewis IJ, Bailey CC (1991) Progressive renal toxicity due to Ifosfamide. Arch Dis Child 66: 966
8. Jackle-Meyer I, Gwinner W, Baum M, Soose M, Petzoldt R, Schmoll HJ, Stolte H (1990) Significance of Tamm-Horsfall protein excretion in diabetes mellitus and cisplatin nephrotoxicity. Contrib Nephrol 83: 124
9. Kumar S, Muchmore A (1990) Tamm-Horsfall protein-uromodulin (1950-1990). Kidney Int 37: 1395
10. Lyn KL, Marshall RD (1984) Excretion of Tamm-Horsfall alycoprotein in renal disease. Clin Nephrol 22: 253
11. McLaughin PJ, Aikawa A, Davies HM, Ward RG, Bakran A, Sells RA, Johnson PM (1993) Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. Clin Sci 84: 243
12. Pinkerton CR, Rodgers H, James C (1985) A phase II study of ifosfamide in children with recurrent solid tumours. Cancer Chemother Pharmacol 15: 258
13. Pratt CB, Horowitz ME, Meyer WH, Etcubanas E, Thompson EI, Douglass EC, Willimas JA, Hayes FA, Green AA (1987) Phase II trial of ifosfamide in children with malignant solid tumours. Cancer Treat Rep 71: 131
14. Pratt CB, Meyer WH, Jenkins JJ, Aver L, McKay CP, Wyatt RJ, Hancock ML (1991) Ifosfamide. Fanconi's syndrome and rickets. J Clin Oncol 9: 1495
15. Rossi R, Ehrich JHH (1993) Partial and complete de Toni-Debre-Fanconi syndrome after ifosfamide chemotherapy of childhood malignancy. Eur J Clin Pharmacol 44 [Suppl 1]: S43
16. Skinner R, Pearson ADJ, Price L, Coulthard MG, Craft AW (1990) Nephrotoxicity after ifosfamide. Arch Dis Child 65: 732
17. Skinner R, Pearson ADJ, Coulthard MG, Skillen AW, Hodson AW, Goldfinch M, Gibb I, Craft AW (1991) Assessment of chemotherapy-associated nephrotoxicity in children with cancer. Cancer Chemother Pharmacol 28: 81
18. Skinner R, Pearson ADJ, Price L, Coulthard MG, Craft AW (1992) The influence of age on nephrotoxicity following chemotherapy in children. Br J Cancer 66 [Suppl 18]: S30
19. Skinner R, Sharkey IM, Pearson ADJ, Craft AW (1993) Ifosfamide, mesna and nephrotoxicity in children. J Clin Oncol 11: 173
20. Skinner R, Pearson ADJ, Craft AW (1994) Ifosfamide nephrotoxicity in children (letter). Med Pediatr Oncol 22: 153
21. Thornley C, Dawney A, Cattell WR (1985) Human Tamm-Horsfall glycoprotein: urinary and plasma levels in normal subjects and patients with renal disease determined by a fully validated radioimmunoassay. Clin Sci 68: 529
22. Zimmerhackl LB (1993) Evaluation of nephrotoxicity with renal antigens in children: role of Tamm-Horsfall protein. Eur J Clin Pharmacol 44 [Suppl 1]: S39