Tetanus toxin enhances protein kinase C activity translocation and increases polyphosphoinositide hydrolysis in rat cerebral cortex preparations

Journal of Neurochemistry

Volumn 70, Issue 4, 1998, Pages 1636-1643

  Gil, Carles ^a   Ruiz Meana, Marisol ^a   Álava, María ^b   Yavin, Ephraim ^c   Aguilera, José ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Neuronal cultures; Phorbol ester; Phospholipase C; Polyphosphoinositide hydrolysis; Protein kinase C; Synaptosomes; Tetanus toxin

Indexed keywords

CARBACHOL; INOSITOL; INOSITOL PHOSPHATE; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; POLYPHOSPHOINOSITIDE; PROTEIN KINASE C; PROTEINASE; SEROTONIN; SYNAPTOBREVIN; TETANUS TOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; BRAIN SYNAPTOSOME; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; HYDROLYSIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT;

EID: 0031882564     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70041636.x     Document Type: Article

References (46)

1. Aguilera J. and Yavin E. (1990) In vivo translocation and down-regulation of protein kinase C following intraventricular administration of tetanus toxin. J. Neurochem. 54, 339-342.
2. Aguilera J., López L. A., and Yavin E. (1990) Tetanus toxin-induced protein kinase C activation and elevated serotonin levels in the perinatal rat brain. FEBS Lett. 263, 61-65.
3. Aguilera J., Padrós-Giralt C., Habig W. H., and Yavin E. (1993) GT1b ganglioside prevents tetanus toxin-induced protein kinase C activation and down-regulation in the neonatal brain in vivo. J. Neurochem. 60, 709-713.
4. 2+-dependent protease activity is removed. J. Biol. Chem. 270, 31386-31390.
5. Berridge M. J. (1984) Inositol trisphosphate and DAG as second messengers. Biochem. J. 220, 345-360.
6. Berridge M. J., Downes C. P., and Hanley M. R. (1982) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206, 587-595.
7. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
8. Claro E., Fain J. N., and Picatoste F. (1993) Noradrenaline stimulation unbalances the phosphoinositide cycle in rat cerebral cortical slices. J. Neurochem. 60, 2078-2086.
9. Facchiano F. and Luini A. (1992) Tetanus toxin potently stimulates tissue transglutaminase. A possible mechanism of neurotoxicity. J. Biol. Chem. 267, 13267-13271.
10. Facchiano F., Benfenati F., Valtorta F., and Luini A. (1993) Covalent modification of synapsin I by a tetanus toxin-activated transglutaminase. J. Biol. Chem. 268, 4588-4591.
11. Farrar W. L., Thomas T. P., and Anderson W. B. (1985) Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C. Nature 315, 235-237.
12. Folck J. E. (1980) Transglutaminases. Annu. Rev. Biochem. 49, 517-531.
13. Goode N. T., Hajibagheri N. M. A., and Parker P. J. (1995) Protein kinase C (PKC)-induced PKC down-regulation. J. Biol. Chem. 270, 2669-2673.
14. Goodnight J., Mischak H., Kolch W., and Mushinski F. (1995) Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. J. Biol. Chem. 270, 9991-10001.
15. Gray E. G. and Whittaker U. P. (1962) The isolation of nerve ending from brain: an electron-microscope study of cell fragments derived by homogenization and centrifugation. J. Anat. 96, 1-36.
16. Hong D.-H., Huan J., Ou B.-R., Yeh J.-Y., Saido T. C., Cheeke P. R., and Forsberg N. E. (1995) Protein kinase C isoforms in muscle cells and their regulation by phorbol ester and calpain. Biochim. Biophys. Acta 1267, 45-54.
17. 3 domain mutants with differential sensitivities to m-calpain are not resistant to phorbol-ester-induced down-regulation. Eur. J. Biochem. 223, 259-263.
18. Kishimoto A., Mikawa K., Hashimoto K., Yasuda I., Tanaka S., Tominaga M., Kuroda T., and Nishizuka Y. (1989) Limited proteolysis of protein kinase C by calcium-activated neutral protease (calpain). J. Biol. Chem. 264, 4088-4092.
19. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Lazarovici P. and Yavin E. (1986) Molecular interactions of tetanus toxin with guinea pig synaptosomal preparations: evidence for a ganglioside-protein receptor complex. Biochemistry 25, 7047-7054.
21. Lazarovici P., Tayot J. L., and Yavin E. (1984) Affinity chromatography purification and characterization of two iodinated tetanotoxin fractions exhibiting different binding properties. Toxicon 22, 401-413.
22. Lee H., Smith L., Pettit G., Vinitsky A., and Smith J. B. (1996) Ubiquitination of protein kinase C-α and degradation by the proteasome. J. Biol. Chem. 271, 20973-20976.
23. Link E., Edelmann L., Chou J. H., Binz T., Yamasaki S., Eisel U., Baumert M., Südhof T. C., Niemann H., and Jahn R. (1992) Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis. Biochem. Biophys. Res. Commun. 189, 1017-1023.
24. Link E., MacMahon H., Vonmollard G. F., Yamasaki S., Niemann H., and Jahn R. (1993) Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes. J. Biol. Chem. 268, 18423-18426.
25. Louis J.-C., Magal E., and Yavin E. (1988) Protein kinase C alterations in the fetal rat brain after global ischemia. J. Biol. Chem. 263, 19282-19285.
26. McMahon H. T., Ushkaryov Y. A., Edelman L., Link E., Binz T., Niemann H., Jahn R., and Sudhof T. C. (1993) Cellubrevin is a ubiquitous tetanus toxin substrate homologous to a putative synaptic vesicle fusion protein. Nature 364, 346-349.
27. Mellanby J. (1984) Comparative activity of tetanus and botulinum toxins. Neuroscience 11, 29-34.
28. Middlebrook J. L. (1986) Cellular mechanism of action of botulinum neurotoxin. J. Toxicol. Toxin Rev. 5, 177-190.
29. Montecucco C. and Schiavo G. (1994) Mechanism of action of tetanus and botulinum neurotoxins. Mol. Microbiol. 13, 1-8.
30. Newton A. C. (1995) Protein kinase C: structure, function, and regulation J. Biol. Chem. 270, 28495-28498.
31. Niemann H., Blasi J., and Jahn R. (1994) Clostridial neurotoxins: new tools for dissecting exocytosis. Trends Cell Biol. 4, 179-185.
32. Nishizuka Y. (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484-496.
33. Orr N., Yavin E., Shintzky M., and Lester D. S. (1990) Application of high pressure to subfractionate membrane protein-lipid complexes: a case study of protein kinase C. Anal. Biochem. 191, 80-85.
34. Parton R. G., Davison M. D., and Critchley D. R. (1989) Comparison of the binding characteristics of two different preparations of tetanus toxin to rat brain membranes. Toxicon 27, 127-135.
35. Poulain B., Rossetto O., Deloye F., Schiavo G., Taue L., and Montecucco C. (1993) Antibodies against rat brain vesicle-associated membrane protein (synaptobrevin) prevent inhibition of acetylcholine release by tetanus toxin or botulinum neurotoxin type B. J. Neurochem. 61, 1175-1178.
36. Presek P., Jessen S., Dreyer F., Jarvie P. E., Findik D., and Dunkley P. R. (1992) Tetanus toxin inhibits depolarization-stimulated protein phosphorylation in rat cortical synaptosomes: effect on synapsin I phosphorylation and translocation. J. Neurochem. 59, 1336-1343.
37. Saido T. C., Sorimachi H., and Suzuki K. (1994) Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 8, 814-822.
38. Savart M., Letard P., Bultel S., and Ducastaing A. (1992) Induction of protein kinase C down-regulation by the phorbol ester IPA in a calpain/protein kinase C complex. Int. J. Cancer 52, 399-403.
39. Savart M., Verret C., Dutaud D., Touyarot K., Elamrani N., and Ducastaing A. (1995) Isolation and identification of a μ-calpain-protein kinase Cα complex in skeletal muscle. FEBS Lett. 359, 60-64.
40. Schiavo G., Benfenati F., Poulain B., Rossetto O., Polverino P., Dasgupta B. R., and Montecucco C. (1992a) Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature 359, 832-834.
41. Schiavo G., Poulain B., Fabio R., Benfenati F., Tauc L., and Montecucco C. (1992b) Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc. EMBO J. 11, 3577-3583.
42. 2 by Clostridium difficile toxin B. J. Cell. Biochem. 52, 116-124.
43. Simpson L. L., ed (1989) Botulinum Neurotoxin and Tetanus Toxin. Academic Press, San Diego.
44. van Heyningen S. (1986) Tetanus toxin, in Pharmacology of Bacterial Toxins (Dorner F. and Drews J., eds), pp. 546-569. Pergamon, Oxford.
45. Wellhöner H. H. (1992) Tetanus and botulinum neurotoxins, in Handbook of Experimental Pharmacology, Vol. 102 (Herken H. and Hucho F., eds), pp. 357-417. Springer-Verlag Berlin.
46. Yavin E., Yavin Z., Habig W. H., Hardegree M. C., and Kohn L. D. (1981) Tetanus toxin association with developing neuronal cell cultures Kinetic parameters and evidence for ganglioside-mediated internalization. J. Biol. Chem. 256, 7014-7022.