In vitro metabolism by human skin and fibroblasts of retinol, retinal and retinoic acid

Experimental Dermatology

Volumn 7, Issue 1, 1998, Pages 27-34

  Bailly, J ^a,c   Crettaz, M ^a,d   Schifflers, M H ^a   Marty, J P ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d R and D   (Switzerland)

Author keywords

Fibroblast; Metabolism; Retinal; Retinoic acid; Retinol; Skin

Indexed keywords

RETINAL; RETINOIC ACID; RETINOL;

ARTICLE; CELL CULTURE; CELL METABOLISM; CONTROLLED STUDY; DERMIS; DRUG METABOLISM; DRUG TISSUE LEVEL; EPIDERMIS; FIBROBLAST CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; SKIN BIOPSY; SKIN FIBROBLAST;

EID: 0031882232     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0625.1998.tb00299.x     Document Type: Article

References (25)

1. Chytil, F. Retinoic acid: Biochemistry and metabolism. J Am Acad Dermatol 1986: 15: 741-747.
2. Bhat P V, Jetten A M. Metabolism of all-trans retinol and all-trans retinoic acid in rabbit tracheal epithelial cells in culture. Biochem Biophys 1987: 922: 18-27.
3. Napoli J L, Race K R. The biosynthesis of retinoic acid from retinol by rat tissues in vitro. Arch Biochem Biophy 1987: 255: 95-101.
4. Napoli J L. Retinol metabolism in LLC-PK1 cells. J Biol Chem 1986: 261: 13592-13597.
5. Williams J B, Napoli J L. Metabolism of retinoic acid and retinol during differentiation of F9 embryonal carcinoma cells. Proc Natl Acad Sci USA 1985: 82: 4658-4662.
6. Tormä H, Vahlquist A. Vitamin A uptake by human skin in vitro. Arch Dermatol Res 1984: 276: 390-395.
7. Siegenthaler G, Saurat J H, Ponec M. Retinol and retinal metabolism. Biochem J 1990: 268: 371-378.
8. Siegenthaler G, Gumowski-Sunek D, Saurat J H. Metabolism of natural retinoids in psoriatic epidermis. J Invest Dermatol 1990: 98: 47s-48s.
9. Randolph R K, Simon M. Characterization of retinol metabolism in cultured human epidermal keratinocytes. J Biol Chem 1993: 268: 9198-9205.
10. Rollman O, Wood E, Olsson M, Cunliffe W. Biosynthesis of 3,4-didehydroretinol from retinol by human skin keratinocytes in culture. Biochem J 1993: 293: 675-682.
11. Kurlandsky S, Xiao J-H, Duell E, Voorhees J, Fisher G. Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes. J Biol Chem 1994: 269: 32821-32827.
12. Connors M J, Smit M H. The formation of all-trans-retinoic acid from all-trans-retinol in hairless mouse skin. Biochem Pharmacol 1987: 36: 919-924.
13. Diderjean L, Carraux P, Grand D, Sass J O, Nau H, Saurat J H. Topical retinaldehyde increases skin content of retinoic acid and exerts biological activity in mouse skin. J Invest Dermatol 1996: 107: 714-719.
14. Sass J O, Didierjean L, Carraux P, Plum C, Nau H, Saurat J H. Metabolism of topical retinaldehyde and retinol by mouse skin in vivo: predominant formation of retinyl esters and identification of 14-hydroxy-4, 14-retro-retinol. Exp Dermatol 1996: 5: 267-271.
15. Kang S, Duell E, Fisher G et al. Application of retinol to human skin induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 1995: 105: 549-556.
16. Saurat J H, Didierjean L, Masgrau E et al. Topical retinaldehyde on human skin: biologic effects and tolerance. J Invest Dermatol 1994: 103: 770-774.
17. Collier S W, Sheikh N M, Lichtin J L, Stewart R F, Bronaugh R L. Maintenance of skin viability during in vitro percutaneous absorption/metabolism studies. Tox Appl Pharmacol 1989: 99: 522-533.
18. Reynolds N, Fisher G, Griffiths C et al. Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo. J Pharmacol Exp Ther 1993: 266: 1636-1642.
19. Schaefer H. Penetration and percutaneous absorption of topical retinoids. Skin Pharmacol 1993: 6: 17-23.
20. Sass J O, Masgreau E, Piletta P A, Nau H, Saurat J H. Plasma retinoids after topical use of retinaldehyde on human skin. Skin Pharmacol 1996: 9: 322-326.
21. Buchan P, Eckhoff C, Caron D, Nau H, Shroot B, Shaefer H. Repeated topical administration of all-trans-retinoic and plasma levels of retinoic acids in human. J Am Acad Dermatol 1993: 30: 428-434.
22. Kang S, Duell E, Kim K J, Voorhees J J. Liarozole inhibit human epidermal retinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo. J Invest Dermatol 1996: 107: 183-187.
23. Kurlandsky S, Duell E, Kang S, Voorhees J, Fisher G. Auto-regulation of retinoic acid biosynthesis through regulation of retinol esterification in human keratinocytes. J Biol Chem 1996: 271: 15346-15352.
24. Edler J, Kaplan A, Cromie M, Kang S, Voorhees J J. Retinoid induction of CRAPB II mRNA in human dermal fibroblasts: use as a retinoid bioassay. J Invest Dermatol 1996: 106: 517-521.
25. Harper R. Specificity in the synergism between retinoic acid and EGF on the growth of adult human skin fibroblasts. Exp Cell Res 1988: 178: 254-263.