Improvement in the mechanical efficiency of walking: An explanation for the 'placebo effect' seen during repeated exercise testing of patients with heart failure

American Heart Journal

Volumn 135, Issue 1, 1998, Pages 107-114

  Russell, S D ^a   McNeer, F R ^a   Beere, P A ^a   Logan, L J ^a   Higginbotham, M B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PLACEBO; VASODILATOR AGENT;

ANAEROBIC THRESHOLD; ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ENERGY EXPENDITURE; EXERCISE TEST; FEMALE; HEART REHABILITATION; HEMODYNAMIC PARAMETERS; HUMAN; LUNG GAS EXCHANGE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE; WALKING;

EID: 0031881823     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(98)70350-3     Document Type: Article

References (31)

1. Captopril Multicenter Research Group A placebo-controlled trial of captopril in refractory chronic congestive heart failure J Am Coll Cardiol 2 1983 755 763
2. EJ Brown PH Chew A MacLean K Gelperin JP Ilgenfritz M Blumenthal for the Fosinopril Heart Failure Study Group Effects of fosinopril on exercise tolerance and clinical deterioration in patients with chronic congestive heart failure not taking digitalis Am J Cardiol 75 1995 596 600
3. T Gundersen K Swedberg O Amtorp J Remes B Nilsson on behalf of the Ramipril Study Group Absence of effect on exercise capacity of 12-weeks treatment with ramipril in patients with moderate congestive heart failure Eur Heart J 15 1994 1659 1665
4. S Ziesche FR Cobb JN Cohn G Johnson F Tristani for the V-HeFT VA Cooperative Studies Group Hydralazine and isosorbide dinitrate combination improves exercise tolerance in heart failure: results from V-HeFT I and V-HeFT II Circulation 87 Suppl VI 1993 56 64
5. CV Leier P Huss RD Magorien DV. Unverferth Improved exercise capacity and differing arterial and venous tolerance during chronic isosorbide dinitrate therapy for congestive heart failure Circulation 67 1983 817 822
6. J Myers VF. Froelicher Optimizing the exercise test for pharmacological investigations Circulation 82 1990 1839 1846
7. DJ Pinsky D Ahern PB Wilson ML Kukin M. Packer How many exercise tests are needed to minimize the placebo effect of serial exercise testing in patients with chronic heart failure [abstract]? Circulation 80 Suppl II 1989 II426
8. JS Elborn CF Stanford DP. Nicholls Reproducibility of cardiopulmonary parameters during exercise in patients with chronic cardiac failure: the need for a preliminary test Eur Heart J 11 1990 75 81
9. MWI Webster DN. Sharpe Exercise testing in angina pectoris: the importance of protocol design in clinical trials Am Heart J 117 1989 505 508
10. M. Packer How should we judge the efficacy of drug therapy in patients with chronic congestive heart failure? The insights of six blind men J Am Coll Cardiol 9 1987 433 438
11. GH Guyatt SO Pugsley MJ Sullivan PJ Thompson LB Berman NL Jones Effect of encouragement on walking test performance Thorax 39 1984 818 822
12. PO Astrand K. Rodahl Textbook of work physiology: physiological bases of exercise 1977 McGraw-Hill New York 333 365
13. TB Levine JN. Cohn Determinants of acute and long-term response to converting enzyme inhibitors in congestive heart failure Am Heart J 104 1982 1159 1164
14. NA Awan MK Evenson KE Needham A Win DT. Mason Efficacy of oral angiotensin-converting enzyme inhibition with captopril therapy in severe chronic normotensive congestive heart failure Am Heart J 101 1981 22 31
15. K Wasserman BJ Whipp SN Koyal WL. Beaver Anaerobic threshold and respiratory gas exchange during exercise J Appl Physiol 35 1973 236 243
16. WL Beaver K Wasserman BJ. Whipp A new method for detecting anaerobic threshold by gas exchange J Appl Physiol 60 1986 2020 2027
17. CA Simonton MB Higginbotham FR. Cobb The ventilatory threshold: quantitative analysis of reproducibility and relation to arterial lactate concentration in normal subjects and in patients with chronic congestive heart failure Am J Cardiol 62 1988 100 107
18. R Margaria P Cerretelli P Aghemo G. Sassi Energy cost of running J Appl Physiol 18 1963 367 370
19. K Wasserman AL Van Kessel GG. Burton Interaction of physiological mechanisms during exercise J Appl Physiol 22 1967 71 85
20. V Bunc J. Leso Ventilatory threshold and work efficiency during exercise on a cycle and rowing ergometer J Sports Sci 11 1993 43 48
21. M Brown JO. Holloszy Effects of a low intensity exercise program on selected physical performance characteristics of 60- to 71- year olds Aging 3 1991 129 139
22. M Brown JO. Holloszy Effects of walking, jogging and cycling on strength, flexibility, speed and balance in 60- to 72-year olds Aging Clin Exp Res 5 1993 427 434
23. JO Judge M Underwood T. Gennosa Exercise to improve gait velocity in older persons Arch Phys Med Rehabil 74 1993 400 406
24. MJ Sullivan MB Higginbotham FR. Cobb Exercise training in patients with severe left ventricular dysfunction: hemodynamic and metabolic effects Circulation 78 1988 506 515
25. MJ Sullivan MB Higginbotham FR. Cobb Exercise training in patients with chronic heart failure delays ventilatory anaerobic threshold and improves submaximal exercise performance Circulation 79 1989 324 329
26. AJS Coats S Adamopoulos A Radaelli A McCance TE Meyer L Bernardi Controlled trial of physical training in chronic heart failure: exercise performance, hemodynamics, ventilation, and autonomic function Circulation 85 1992 2119 2131
27. EH Conn RS Williams AG. Wallace Exercise responses before and after physical conditioning in patients with severely depressed left ventricular function Am J Cardiol 49 1982 296 300
28. KT Weber GT Kinasewitz JS Janicki AP. Fishman Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure Circulation 65 1982 1213 1223
29. DP Lipkin J Perrins PA. Poole-Wilson Respiratory gas exchange in the assessment of patients with impaired ventricular function Br Heart J 54 1985 321 328
30. JA Franciosa the Captopril-Digitalis Research Group Contribution of metabolic measurements to exercise testing in congestive heart failure [abstract] J Am Coll Cardiol 5 1985 513
31. Committee on Evaluation and Management of Heart Failure Guidelines for the evaluation and management of heart failure: Report of the American College of Cardiology/American Heart Association task force on practice guidelines J Am Coll Cardiol 26 1995 1376 1398