An efficient synthetic strategy for the preparation of 2,3,6,7-tetrahydro-3-phenyl-4H-oxazolo[3,2-a]-1,3,5-triazin-2,4-diones

Pharmacy and Pharmacology Communications

Volumn 4, Issue 1, 1998, Pages 9-12

  Forfar, I ^a   Bosc, J J ^a   Leger, J M ^a   Jarry, C ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,6,7 TETRAHYDRO 3 PHENYL 4H OXAZOLO[3,2A] 1,3,5 TRIAZIN 2,4 DIONE; OXAZOLINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

CHEMICAL REACTION; CONFERENCE PAPER; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 0031881151     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (9)

1. Bosc, J. J., Jarry, C. (1996) Investigation of the reaction of phenylisocyanate with N-substituted 2-iminooxazolines. Heterocyclic Commun. 2: 355-358
2. Bosc, J. J., Forfar, I., Jarry, C. (1997) Synthesis of 2,3,6,7-tetrahydro-7-methoxymethyl-4H-oxazolo[3,2-a]-1,3,5-triazin-2,4-diones as potential anti-inflammatory agents. Pharm. Sci. 3: 291-293
3. Bosc, J. J., Jarry, C., Ouhabi, J., Laguerre, M., Carpy, A. (1996) New investigation of the reaction of 2-amino-2-oxazolines with isocyanates and isothyocyanates. Evidence of a transposition during the second step. Can. J. Chem. 74: 1341-1347
4. Crank, G. (1973) Anti-inflammatory oxazolo[3,2-a]-s-triazin-5,7-diones. US Pat. 3719676 (CA: 78 148006)
5. Crank, G., Foulis, M. J. (1971) Derivatives of 2-aminooxazolines showing anti-inflammatory activity. J. Med. Chem. 14: 1075-1077
6. Jarry, C., Forfar, I., Thomas, J., Leger, J. M., Laguerre, M. (1993) Reaction of 5-substituted 2-amino-2-oxazolines with ethoxycarbonylisothiocyanate. Heterocycles 36: 2465-2473
7. Rasmussen, C. R., Villani, F. J., Mutter, M. S., Griffin, E. A. (1986) Reactions of 4,5-dihydro-2-thiazolamine with phenyl isothiocyanate and phenyl isocyanate: a reinvestigation. J. Org. Chem. 51: 1910-1912
8. Sheldrick, G. M. (1993) SHELX93, Program for the refinement of crystal structures. University of Göttingen, Germany
9. 2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4-(3H)-dione derivatives. J. Med. Chem. 35: 189-194