Impaired reactivity of rat aorta to phenylephrine and KCL after prolonged hypoxia: Role of the endothelium

Journal of Applied Physiology

Volumn 85, Issue 2, 1998, Pages 411-417

  Auer, Grant ^a   Ward, Michael E ^a,b  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Oxygen delivery; Phenylephrine; Potassium chloride; Vascular smooth muscle

Indexed keywords

PHENYLEPHRINE; POTASSIUM CHLORIDE;

AORTA; ARTERY TONE; ARTICLE; BLOOD OXYGEN TENSION; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; VASCULAR ENDOTHELIUM; VASCULAR RING;

EID: 0031880328     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.2.411     Document Type: Article

References (30)

1. Aoki, V. S., and S. M. Robinson. Hindquarters vascular responses in chronically hypoxic rats. Am. J. Physiol. 9: 427-435, 1961.
2. Arnet, U. A., A. McMillan, J. L. Dinerman, B. Ballermann, and C. J. Lowenstein. Regulation of endothelial nitric-oxide synthase during hypoxia. J. Biol. Chem. 271: 15069-15073, 1996.
3. 2 as an endothelium-derived contracting factor modulates endothelin-1 induced contraction. J. Hypertens. 12: 383-390, 1994.
4. Auch-Schwelk, W., and P. M. Vanhoutte. Contractions to endothelin in normotensive and spontaneously hypertensive rats: role of endothelium and prostaglandins. Blood Press. 1: 45-49, 1992.
5. 2 extraction by canine hindlimb during α-adrenergic blockade and hypoxic hypoxia. J. Appl. Physiol. 48: 630-635, 1980.
6. Delp, M. D., R. M. McAllister, and M. H. Laughlin. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J. Appl. Physiol. 75: 1354-1363, 1993.
7. Doyle, M. P., and B. R. Walker. Attenuation of systemic vasoreactivity in chronically hypoxic rats. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29): R1114-R1122, 1991.
8. Elton, T. S., S. Oparil, G. R. Taylor, P. H. Hicks, R. H. Yang, H. Jin, and Y. F. Chen. Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R1260-R1264, 1992.
9. 2. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H706-H715, 1994.
10. 2 on agonist-induced contractility of rat aorta. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H512-H519, 1993.
11. Harrison, G. L., I. F. McMurtry, and L, G. Moore, Meclofenamate potentiates vasoreactivity to α-adrenergic stimulation in chronically hypoxic guinea pigs. Am. J. Physiol. 251 (Heart Circ. Physiol. 20): H496-H501, 1986.
12. Heistad, D. D., R. C. Wheeler, and V. S. Aoki. Reflex cardiovascular responses after 36 hr of hypoxia. Am. J. Physiol. 220: 1673-1676, 1971.
13. Jansakul, C. Effects of swimming on vascular reactivity to phenylephrine and KCl in male rats. Br. J. Pharmacol. 115: 587-594, 1995.
14. Jin, H., R.-H. Yang, Y.-F. Chen, R. M. Thornton, R. M. Jackson, and S. Oparil. Hemodynamic effects of arginine vasopressin in rats adapted to chronic hypoxia. J. Appl. Physiol. 66: 151-160, 1989.
15. Kenmure, A. C. F., W. R. Murdoch, A. D. Beattie, J. C. B. Marshall, and A. J. V. Cameron. Circulatory and metabolic effects of oxygen in myocardial infarction. Br. Med. J. 627: 360-364, 1968.
16. Kuwahira, I., N. C. Gonzalez, N. Heisler, and J. Piiper. Changes in regional blood flow distribution and oxygen supply during hypoxia in conscious rats. J. Appl. Physiol. 74: 211-214, 1993.
17. Liao, J. K., J. J. Zulueta, F. S. Yu, H. B. Peng, C. G. Cote, and P. M. Hassoun. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J. Clin. Invest. 96: 2661-2666, 1995.
18. McQuillan, L. P., G. K. Leung, P. A. Marsden, S. K. Kostyk, and S. Kourembanas. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1921-H1927, 1994.
19. Messina, E. J., D. Sun, A. Koller, M. S. Woin, and G. Kaley. Role of endothelium-derived prostaglandins in hypoxia-elicited arteriolar dilation in rat skeletal muscle. Circ. Res. 71: 790-796, 1992.
20. Mian, R., and J. M. Marshall. Responses observed in individual arterioles and venules of rat skeletal muscle during systemic hypoxia. J. Physiol. (Lond.) 436: 485-497, 1991.
21. Nakhostine, N., and D. Lamontagne. Contribution of prostaglandins in hypoxia induced vasodilation in isolated rabbit hearts: relation to adenosine and KATP channels. Pflügers Arch. 428: 526-532, 1994.
22. Paredes-Carbajal, M. C., M. A. Juarez-Oropeza, C. M. Ortiz-Mendoza, and D. Mascher. Effects of acute and chronic estrogenic treatment on vasomotor responses of aortic rings from ovariectomized rats. Life Sci. 57: 473-486, 1995.
23. Pearce, W. J., S. Ashwal, and J. Cuevas. Direct effects of graded hypoxia on intact and denuded rabbit cranial arteries. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H824-H833, 1989.
24. Pearson, P. J., P. J. Lin, P. R. B. Evora, and H. V. Schaff. Endothelium-dependent response of human internal mammary artery to hypoxia. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H376-H380, 1993.
25. Richards, J. M., I. F. Gibson, and W. Martin. Effects of hypoxia and metabolic inhibitors on production of prostacyclin and endothelium-derived relaxing factor by pig aortic endothelial cells. Br. J. Pharmacol. 102: 203-209, 1991.
26. Taddei, S., and P. M. Vanhoutte. Role of endothelium in endothelin-evoked contractions in the rat aorta. Hypertension 21: 9-15, 1993.
27. 2. J. Cardiovasc. Pharmacol. 22: S328-S331, 1993.
28. Ward, M. E. Interaction between hypoxia and hypercapnia in regulation of arteriolar diameter in the canine diaphragm. J. Appl. Physiol. 80: 802-809, 1996.
29. Ward, M. E., and S. N. A. Hussain. Effect of α-adrenergic stimulation on diaphragmatic oxygen extraction. J. Crit. Care 11: 19-26, 1996.
30. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 80: 892-894, 1994.