Fine structural changes and apoptotic cell death by T-2 mycotoxin

Journal of Toxicological Sciences

Volumn 23, Issue SUPPL. 2, 1998, Pages 148-154

  Sugamata, Masao ^a   Hattori, Tsukiko ^a   Ihara, Tomomi ^a   Okumura, Hiroki ^b   Yoshino, Naoto ^b   Ueno, Yoshio ^b  

^a Inst of Tochigi Clin Pathol Inc ^*  (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; MYCOTOXIN;

APOPTOSIS; CELL DEATH; CONFERENCE PAPER; DNA DETERMINATION; ELECTRON MICROSCOPY; HISTOPATHOLOGY;

EID: 0031880281     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.23.supplementii_148     Document Type: Conference Paper

References (5)

1. Saito M, Ohtsubo K (1974): Trichothecene toxins of Fusarium species. In Purchase IFH (ed): Mycotoxins, Amsterdam: Elsevier, pp263-281
2. Ueno Y, Sato N, Ishii K, Sakai K, Enomoto M, (1972): Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287. Jpn J Exp Med 42:461-472.
3. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992): Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501.
4. Yoshino N, Takizawa M, Akiba H, Okumura H, Tashiro F, Honda M, Ueno Y (1996): Transient elevation of intracellular calcium ion levels as an early event in T-2 toxin induced apoptosis in human promyelotic cell line HL-60. Nat Toxins, 4: 178-186.
5. Yoshino N, Takizawa M, Okumura H, Ihara T, Sugamata M, Tashiro F, Ueno Y (1997): Nivalenol induced apoptosis in human peripheral blood lymphocytes in vitro and mouse peripheral blood lymphocytes in vivo. Mycotoxins, in press.