Cocaine and lidocaine with phenylephrine as topical anesthetics: Antimicrobial activity against common nasal pathogens

Ear, Nose and Throat Journal

Volumn 77, Issue 7, 1998, Pages 554-557

  Aldous, Wade K ^a,b   Jensen, Ray ^a,b   Sieck, Brian M ^a,b  

^a Madigan Army Medical Center ^*

^b MADIGAN ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; COCAINE; LIDOCAINE; PHENYLEPHRINE;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG EFFECT; ENTEROBACTER CLOACAE; HAEMOPHILUS INFLUENZAE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NONHUMAN; NOSE INFECTION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; TOPICAL ANESTHESIA;

EID: 0031880114     PISSN: 01455613     EISSN: None     Source Type: Journal    
DOI: 10.1177/014556139807700713     Document Type: Article

References (15)

1. Lebeda MD, Haller JR, Graham SM, et al. Evaluation of maxillary sinus aspiration in patients with fever of unknown origin. Laryngoscope 1995;105:683-5.
2. Bach A, Boehrer H, Schmidt H, et al. Nosocomial sinusitis in ventilated patients. Nasotracheal vs orotracheal intubation. Anaesthesia 1994;47:335-9.
3. Brook I. Bacteriology of chronic maxillary sinusitis in adults. Ann Otol Rhinol Laryngol 1989;98 426-8.
4. Caplan ES, Hoyt NJ. Nosocomial sinusitis. JAMA 1982;247:639-41.
5. Evans FO Jr, Sydnor JB, Moore WE, et al. Sinusitis of the maxillary antrum N Engl J Med 1975;293-735-9.
6. Kleinfeld J, Ellis PP. Effects of topical anesthetics on growth of microorganisms. Arch Opthalmol 1966;76:712-5.
7. Weinstein MP, Maderazo E, Tilton R, et al. Further observations on the antimicrobial effects of local anesthetic agents. Curr Ther Res 1975;17:369-74.
8. Ohsuka S, Ohta M, Masuda K, et al. Lidocaine hydrochloride and acetylsalicylate kill bacteria by disrupting the bacterial membrane potential in different ways. Microbiol Immunol 1994; 38:429-34.
9. Schmidt RM, Rosenkranz HS. Antimicrobial activity of local anesthetics. Lidocaine and procaine. J Infect Dis 1970;121:597-607.
10. Wimberly N, Willey S, Sullivan, et al. Antibacterial properties of lidocaine. Chest 1979;76;37-40.
11. Miller MA, Shelley WB Antibacterial properties of lidocaine on bacteria isolated from dermal lesions. Arch Dermatol 1985; 121:1157-9.
12. Zenilman JM, Reichart CA, Neumann TM, et al. Cocaine hydrochloride and benzoylecogonine have no in vitro inhibitory effect against Neisseria gonorrhoeae. Antimicrob Agents Chemother 1991;35:1228-9.
13. Erlich H. Bacteriologic studies and effects of anesthetic solutions on bronchial secretions during bronchoscopy. Am Rev Respir Dis 1961;84:414-21.
14. Schweitzer ME, Deely DM, Beavis K, et al. Does the use of lidocaine affect the culture of percutaneous bone biopsy specimens obtained to diagnose osteomyelitis? An in vitro and in vivo study. Am J Roentgenol 1995;164:1201-3.
15. Thompson KD, Welykyj S, Massa MC. Antibacterial activity of lidocaine in combination with a bicarbonate buffer. J Dermatol Surg Oncol 1993;19:216-20.