The effect of hyperglycaemia on regional cerebral glucose oxidation in humans studied with [1-11C]-D-glucose

Acta Physiologica Scandinavica

Volumn 163, Issue 4, 1998, Pages 403-415

  Blomqvist, G ^a,d   Grill, V ^b   Ingvar, M ^b   Widen L ^b   Stone Elander, S ^b,c  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d DIF   (France)

Author keywords

Cerebral glucose oxidation; Hyperglycaemia; PET

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; BRAIN METABOLISM; BRAIN TOMOGRAPHY; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; HUMAN; HYPERGLYCEMIA; MALE; METABOLIC RATE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0031879810     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1998.t01-1-00360.x     Document Type: Article

References (50)

1. Ackermann, R.F. & Lear, J.L. 1989. Glycolysis-induced discordance between glucose metabolic rates measured with radio labelled fluorodeoxyglucose and glucose. J Cereb Blood Flow Metab 9, 774-785.
2. +-induced stimulation of glucose utilization in rat brain. J Cereb Blood Flour Metab 15, 97-110.
3. Beck, J.V. & Arnold, J.K. 1977. Parameter Estimation in Engineering and Science. John Wiley & Sons, New York.
4. Bergström, M., Boethius, J., Eriksson, L., Greitz, T., Ribbe, T. & Widén, L. 1981. A head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr 5, 137-141.
5. Blomqvist, G. 1984. On the construction of functional maps in positron emission tomography. J Cereb Blood Flour Metab 4, 629-632.
6. glc in rats. Letter to the editor. J Cereb Blood Flow Metab 15, 349-351.
7. Blomqvist, G., Gjedde, A., Gutniak, M., Grill, V., Widén, L., Stone-Elander, S. & Hellstrand, E. 1991. Facilitated diffusion of glucose from blood to brain in man, and the effect of moderate hypoglycaemia on regional cerebral glucose utilization. Eur J Nucl Med 18, 834-837.
8. Blomqvist, G., Lammertsma, A.A., Mazoyer, B. & Wienhard, K. 1995a. Effect of tissue heterogeneity on quantification in positron emission tomography. Eur J Nucl Med 22, 652-663.
9. Blomqvist, G., Seitz, R.J., Sjögren, I., Halldin, C., Stone-Elander, S., Widén, L., Solin, O. & Haaparanta, M. 1994. Regional cerebral oxidative and total glucose consumption during rest and activation studied with positron emission tomography. Acta Physiol Scand 151, 29-43.
10. 11C]-D-glucose. J Cereb Blood Flour Metab 10, 467-483.
11. 11C]3-O-methyl-D-glucose and positron emission tomography. J Cereb Blood Flow Metab 6, 240-244.
12. Bruschiazzo, P.M., Terell, E.B. & Regen, D.M. 1970. Sugar transport across the blood-brain barrier. Am J Physiol 219, 1505-1513.
13. Daniel, P.M., Love, E.R. & Pratt, O.E. 1976. The influence of insulin upon the metabolism of glucose by the brain. Proc B Soc Lond B 196, 85-104.
14. Duckrow, R.B., Beard, D.C. & Brennan, R.W. 1985. Regional cerebral blood flow decreases during hyperglycaemia. Ann Neurol 17, 267-272.
15. Duckrow, R.B. & Bryan, R.M. Jr 1987. Regional cerebral glucose utilization during hyperglycaemia. J Neurochem 48 (3), 989-993.
16. Eriksson, L., Bohm, C., Kesselberg, M. & Holte, S. 1988. An automated blood sampling system used in positron emission tomography. Nucl Sci Appl 3, 133-143.
17. Feinendegen, L.E., Herzog, H., Wieler, H., Patton, D.D. & Schmid, A. 1986. Glucose transport and utilization in the human brain: Model using carbon-11 methyl glucose and positron emission tomography. J Nucl Med 27, 1867-1877.
18. Folbergová, J., Ingvar, M. & Siesjö, B. 1981. Metabolic changes in cerebral cortex, hippocampus, and cerebellum during sustained bicucculine-induced seizures. J Neurochem 37, 1228-1238.
19. Fox, P.T., Raichle, M.E., Mintun, M. & Dence, C. 1988. Non-oxidative glucose consumption during focal physiologic neural activity. Science 241, 462-464.
20. Gjedde, A. 1981. High- and low-affinity transport of D-glucose from blood to brain. J Neurochem 36, 463-471.
21. Gjedde, A. 1983. Modulation of substrate transport to the brain. Acta Neurol Scand 67, 3-25.
22. Gjedde, A., Wienhard, K., Heiss, W.D., Kloster, G., Diemer, N.H., Herholz, K. & Pawlik, G. 1985. Comparative regional analysis of 2-fluorodeoxyglucose and methylglucose uptake in brain of four stroke patients. With special regard to the regional estimation of the lumped constant. J Cereb Blood Flour Metab 5, 163-178.
23. Gottstein, U. & Held, K. 1967. Insulinwirkung auf den menschlichen Hirnmetabolisms von Stoffwechselgesunden und Diabetikern. Klin Wshr 45, 18-23.
24. Gottstein, U., Held, K., Sebening, H. & Walpurger, G. 1965. Der Glucosenverbrauch des menschlichen Gehirns unter dem Einfluss intravenöser Infusionen von Glukose, Glucogon und Glukose-Insulin. Klin Wschr 43, 965-970.
25. Greitz, T., Bohm, C., Holte, S. & Eriksson, L. 1991. A computerized brain atlas: construction, anatomical content, and some applications. J Comput Assist Tomogr 15, 26-38.
26. 13C NMR spectroscopy. Proc Natl Acad Sci USA 89, 1109-1112.
27. 11C]glucose uptake and metabolism of insulin-dependent diabetic subjects. Am J Physiol 258, (Endocrinol Metab 21), E805-E812.
28. Harik, S.I. & LaManna, J.C. 1988. Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycaemia. J Neurochem 51, 1924-1929.
29. Hasselbach, S.G., Knudsen, G.M., Jakobsen, J., Hageman, L. P., Holm, S. & Paulson, O.B. 1994. Brain metabolism during short-term starvation in humans. J Cereb Blood Flour Metab 14, 125-131.
30. 11C]leucine and PET: methods, model, and results in animals and in humans. J Cereb Blood Flour Metab 9, 446-460.
31. Hazel, J.R. & Sidell, B.D. 1987. A method for determination of diffusion coefficients for small molecules in aqueous solution. Anal Biochem 166, 335-341.
32. Knudsen, G.M., Paulson, O.B. & Herz, M.M. 1991. Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia. J Cereb Blood Flow Metab 11, 581-586.
33. Lassen, N.A. 1985. Normal average value of cerebral blood flow in younger adults is 50 ml/100 g/min. J Cereb Blood Flow Metab 5, 347-349.
34. Lassen, N.A. & Gjedde, A. 1983. Kinetic analysis of the uptake of glucose and some of its analogues in the brain using the single capillary model: Comments on some points of controversy. In: R. M. Lambrecht and A. Rescigno, (eds) Lecture Notes in Biomathematics, pp. 384-407, Springer Verlag, Munich.
35. Lear, J.L. & Ackermann, R.F. 1989. Why the deoxyglucose method has proven so useful in cerebral activation studies. The unappreciated prevalence of stimulation-induced glycolysis. J Cereb Blood Flow Metab 9, 911-913.
36. Lewis, L.D., Ljunggren, B., Norberg, K. & Siesjö, B.K. 1974. Changes in carbohydrate substrates, amino acids and ammonia in the brain during insulin-induced hypoglycaemia. J Neurochem 23, 659-662.
37. Litton, J., Holte, S. & Eriksson, L. 1990. Evaluation of the Karolinska new positron camera system; the Scanditronix PC2048-15B. IEEE Trans Nucl Sci 37, 743-748.
38. Mazziotta, J.C. & Phelps, M.E. 1986. Positron tomographic studies of the brain. In: M. E. Phelpsand and J. C. Mazziotta, (eds) Positron Emission Tomography and Autoradiography, pp. 493-579, Raven Press, New York.
39. 14C]deoxyglucose and glucose on λ. J Cereb Blood Flour Metab 9, 304-314.
40. Nelson, T., Lucignani, G., Atlas, S., Crane, A.M., Dienel, G.A. & Sokoloff, L. 1985. Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle. Science 229, 60-62.
41. Nelson, S.R., Schulz, D.W., Passonneau, J.V. & Lowry, O.H. 1968. Control of glycogen levels in brain. J Neurochem 15, 1271-1279.
42. Orzi, F., Lucignani, G., Dow-Edwards, D., Namba, H., Nehlig, A., Patlak, C.S., Pettigrew, K., Schuier, F. & Sokoloff, L. 1988. Local cerebral glucose utilization in controlled graded levels of hyperglycaemia in the conscious rat. J Cereb Blood Flour Metab 8, 346-356.
43. Patlak, C.S., Blasberg, R.G. & Fenstermacher, J.D. 1983. Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data. J Cereb Blood Flour Metab 3, 1-7.
44. Pelligrino, D.A., LaManna, J.C., Duckrow, R.B., Bryan, R.M. Jr & Harik, S.I. 1992. Hyperglycaemia and blood-brain barrier glucose transport. J Cereb Blood Flour Metab 12, 887-899.
45. glc in rats. Letter to the editor; response, J Cereb Blood Flour Metab 15, 349-351.
46. 11C-D-glucose during stepped hypoglycaemia. Ann Neurol 38, 599-609.
47. Redies, C., Hoffer, L.J. & Beil, C. 1989. Generalized decrease in brain glucose metabolism during fasting in humans studied by PET. Am J Physiol 256, E805-E810.
48. Seitz, R.J., Bohm, C., Greitz, T., Roland, P.E., Eriksson, L., Blomqvist, G., Rosenqvist, G. & Nordell, B. 1990. Accuracy and precision of the computerized brain atlas programme for localization and quantification in positron emission tomography. J Cereb Blood Flour Metab 10, 443-457.
49. 11C]d-glucose and related compounds for the measurement of brain glucose metabolism. J Lab Comp Radiopharm 22, 171-182.
50. 2. Appl Radiat Isot 43, 721-729.